Objective: The endophytes with antibacterial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans are isolated and screened from Schisandra chinensis fruit, providing more screening sources for developing new clinical antibacterial drugs. Methods: The inhibitory activities of the endophytes against the three test pathogens were detected by the plate standoff method and Oxford cup method, and the data were statistically analyzed by SPSS Statistics 20.0 software, and the genera of the endophytes were further identified by morphological observation, physiological and biochemical characteristics, and molecular biology methods. Results: 25 endophytic strains were isolated, among which the fermentation broth of strain GF20 had strong antibacterial activity against the three tested pathogenic bacteria. After identification, GF20 was determined to be a bacterium of the genus Bacillus. Conclusion: Schisandra chinensis fruits are rich in endophytic bacteria, which have different antibacterial activities against common pathogenic bacteria and can potentially develop new antibacterial drugs.
WANG Fei
,
ZHAO Amujiletu
,
HE Shan
,
YU Jingda
,
GAO Fang
,
DONG Yanhong
,
RONG Songhao
,
MA Shuyi
. Isolation, screening, and antibacterial activity of Schisandra chinensis endophytes[J]. Journal of Baotou Medical College, 2025
, 41(7)
: 70
-74
.
DOI: 10.16833/j.cnki.jbmc.2025.07.013
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