Objective: To explore the effects of family dietary behavior and dietary structure on overweight/obesity in children aged 6-12 years in Huangdao District of Qingdao City, and to provide a basis for formulating regional intervention strategies. Methods: From October 2023 to February 2024, children aged 6-12 years old in Huangdao District of Qingdao City who came to Qingdao Huangdao District Central Hospital for physical examination were selected as the research objects, and the data were collected by questionnaire survey. The questionnaire included general demographic indicators, basic physical indicators, family factors and dietary survey. Results: A total of 560 valid questionnaires were obtained, with overweight accounting for 17.1%(95/560) and obesity accounting for 22.1%(124/560 ). The proportion of boys in overweight and obesity groups was significantly higher than that in normal group(P＜0.05). Among them, the proportion of mothers with college degree or above and the proportion of nuclear families in the overweight group were higher than those in the normal group(P＜0.05). In terms of family eating behavior, the number of eating out ≥2 times and the number of meals before bedtime in the overweight and obese group were significantly higher than those in the normal group(P＜0.05); the proportion of regular breakfast decreased, and the proportion of regular breakfast in the normal group was significantly higher than that in the obese group(P＜0.05); the sleep duration of the three groups was insufficient, and the number of children with sleep time >10 h per night on the rest day in the obese group was significantly lower than that in the normal group(P＜0.05). In terms of dietary factors, compared with the normal group, the average weekly intake frequency of pancakes/deep-fried dough sticks/deep-fried dough sticks, buns/dumplings/wontons in cereals, processed meat products in meat, carbonated drinks, biscuits/cakes and puffed food in other categories in the overweight and obese groups were higher(P＜0.05). The average weekly intake frequency of tubers in the obese group was significantly lower than that in the normal group, while the intake frequency of livestock meat and Western fast food was higher than that in the normal group(all P＜0.05). Conclusion: The proportion of overweight and obesity in children in Huangdao District of Qingdao City is relatively high. In addition to being related to their own gender, it is also closely related to the type of core family structure, the frequency of eating out, pre-bedtime meals, lack of sleep and high-calorie dietary intake. Interventions should focus on changing family lifestyles and cultivating children′s healthy dietary habits.

Objective: To investigate the potential mechanisms of Prunella vulgaris for the treatment of diabetes mellitus (DM) through network pharmacology and molecular docking methods. Methods: The active ingredients of Prunella vulgaris were screened by TCMSP database, the active ingredient targets of Prunella vulgaris were predicted from STP database, and the related targets of DM were screened in TTD, OMIM, DisGENET and DrugBank disease databases. STRING was used to construct the protein interaction network, Cytoscape 3.8.0 and Omicshare were used for topology analysis, GO function and KEGG pathway enrichment, and the affinity between the active components of Prunella vulgaris and the key targets was verified by molecular docking. Results: Twenty active ingredients and 167 disease targets of Prunella vulgaris were obtained, and and 57 core targets such as serine/threonine-protein kinase 1 (AKT1) were found by network topology analysis. KEGG pathway was enriched in proteoglycans, advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE), C-type lectin receptors and other metabolic pathways in diabetic complications to exert the therapeutic effect of Prunella vulgaris on DM. Molecular docking showed that the core components of spinasterol, morin, stigmast-7-enol, vitamin K, β-sitosterol had good binding activity with amyloid precursor protein (APP), AKT1, interleukin 6 (IL-6) and other targets. Conclusion: Prunella vulgaris mainly mediates phosphatidylinositol-4 through spinasterol, morin, stigmast-7-enol, vitamin K, β-sitosterol and stigmasterol. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), AKT1, mitogen-activated protein kinase 3 (MAPK3), IL-6, APP and other targets regulate proteoglycan and C-type lectin receptor signaling pathways, and play a role in regulating glucose homeostasis and glucose uptake, thereby improving the symptoms of DM and complications.

Objective: To explore the effect and mechanism of cynomorium songaricum flavonoids (CSF) on senescence-accelerated mice prone 8 (SAMP8). Methods: Thirty 7-month-old male SAMP8 mice were selected and randomly divided into control group, cynomorium songaricum flavonoids group, and donepezil group. The SAMP8 mice in the cynomorium songaricum flavonoids group were given cynomorium songaricum flavonoids 50 mg/(kg·d) by gavage for 20 days, and the donepezil group was given donepezil 0.71 mg/(kg·d) by gavage for 20 days. After administration, the Morris water maze was used to evaluate the cognitive function, and Nissl staining was used to observe the morphology and count of hippocampal pyramidal cells. The protein expression levels of NADPH: quinone oxidoreductase-1 (NOQ1), nuclear factor e2 related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in hippocampus were determined by Western blotting. The activity of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in serum were measured by ELISA. Results: Compared with the control group, the distance and escape latency of the mice in the cynomorium songaricum flavonoids were decreased, and the percentage of the number of crossing the platform and the time of the target quadrant were increased (P＜0.05). Compared with the control group, the expression of Nrf2, Keap1 and NOQ1 protein in the hippocampus of the mice in the cynomorium songaricum flavonoids group and donepezil group was increased (P＜0.05). Compared with the control group, the activity of SOD and GSH-Px in the serum of mice in the cynomorium songaricum flavonoids group was increased (P＜0.05), and the content of MDA was decreased (P＜0.05). Conclusion: Cynomorium songaricum flavonoids can improve cognitive dysfunction in SAMP8 mice, and its mechanism may be related to regulating the Nrf2 Keap1 pathway to inhibit oxidative stress.

Objective: To explore the effect of miR-204-5p on the proliferation, migration and invasion of bladder cancer cells by specifically regulating the expression level of TCF12, and to further reveal its mechanism. Methods: The expression levels of miR-204-5p in bladder cancer cells and human urothelial cells, as well as bladder cancer tissues and adjacent tissues were detected by qRT-PCR. CCK-8, Transwell and flow cytometry were used to verify the effect of miR-204-5p on bladder tumor cells. The dual luciferase assay was used to verify the targeting relationship between miR-204-5 p and TCF12. Western-blot and qRT-PCR were used to detect the regulatory effect of miR-204-5p on the expression of TCF12. Results: The expression of miR-204-5p was significantly up-regulated in bladder cancer tissues and cell lines (P＜0.05). The overexpression of miR-204-5p was confirmed to promote the progression of bladder cancer in vitro (P＜0.05). Studies had confirmed that TCF12 was a potential target gene of miR-204-5p, and down-regulation of TCF12 by miR-204-5p promoted the proliferation, migration and invasion of bladder cancer cells. Overexpression of TCF12 could also reverse the effect of miR-204-5p overexpression on bladder cancer cells. Conclusion: miR-204-5p may promote the proliferation, migration and invasion of bladder cancer cells by targeting TCF12 and down-regulating its expression level. Targeting miR-204-5p / TCF12 may provide a potential therapeutic strategy for bladder cancer.

Objective: To explore the expression and clinical value of tripartite motif containing 59 (TRIM59) gene in ovarian cancer based on bioinformatics. Methods: The expression of TRIM59 mRNA in ovarian cancer tissues and ovarian tissues was analyzed by data sets in GEPIA database and GEO database. The expression of TRIM59 protein in ovarian cancer and ovarian tissue was analyzed in The Human Protein Atlas database. Kaplan-Meier database was used to study the correlation between TRIM59 expression and prognosis of ovarian cancer patients. Genes co-expressed with TRIM59 in ovarian cancer were screened from ULACAN database, and GO analysis and KEGG enrichment analysis were performed in DAVID database. The relationship between the expression of TRIM59 mRNA and the infiltration of various immune cells in ovarian cancer was analyzed in TIMER database. Results: The expression level of TRIM59 mRNA in ovarian cancer tissues was significantly higher than that in normal ovarian tissues, and this differential expression was closely related to the survival time of ovarian cancer patients. The results of immunohistochemistry showed that the positive rate of TRIM59 protein in ovarian cancer tissues was 75%, and no expression was found in normal ovarian tissues. In ovarian cancer tissues, 148 co-expressed genes were positively correlated with TRIM59, which were mainly involved in DNA replication, protein synthesis, polysaccharide biosynthesis and P53 signaling pathway. The content of TRIM59 protein in ovarian cancer was positively correlated with the infiltration of CD4⁺ T lymphocytes, neutrophils and NK cells. Conclusion: This study confirms that TRIM59 is highly expressed in ovarian cancer and closely related to the prognosis of ovarian cancer patients, which can be used as a new therapeutic target and diagnostic marker.

Objective: The expression levels and clinical significance of YTHDF1 and YTHDF2 in lung squamous cell carcinoma (LUSC) tissues were analyzed using bioinformatics and immunohistochemical methods. Methods: TCGA database was used to analyze the expression and correlation of MYC and FTO in colorectal cancer.Gene set enrichment analysis (GSEA) revealed the biological functions and signaling pathways associated with YTHDF1 and YTHDF2.Finally,the expression of YTHDF1 and YTHDF2 in LUSC tissues was validated through immunohistochemical experiments,and the correlation between expression levels of YTHDF1 and YTHDF2 and clinical features was analyzed.In addition,we investigated the relation between expression levels of YTHDF1 and YTHDF2 and PD-L1 by statistical methods. Results: (1) YTHDF1 and YTHDF2 were higher in tumors than in adjacent tissues(P＜0.05);(2) YTHDF1 was correlated with T stage and tumor clinical stage(P＜0.05);(3) Age was an independent risk factor for overall survival (OS) of LUSC patients, and YTHDF1 expression and T stage were independent risk factors for disease specific survival (DSS);(4)Genes in the groups with high expression of YTHDF1 and YTHDF2 were mainly enriched in therapeutic targets.Low expression groups of YTHDF1 and YTHDF2 were related to immune activity.(5)YTHDF2 were positively correlated with the expression of PD-L1(P＜0.05). Conclusion: The expression levels of YTHDF1 and YTHDF2 may affect the immune microenvironment of LUSC, revealing its potential as targets and biological markers for immunotherapy.

Objective: To explore the application value of spectral CT iodine quantitative parameters and virtual lung perfusion imaging in the diagnosis of acute pulmonary embolism (APE). Methods: The clinical data of patients with suspected APE who underwent GE spectral CT pulmonary angiography were retrospectively collected. Monoenergetic images, iodine-based material decomposition images and virtual lung perfusion images of 70 keV CT pulmonary angiography (CTPA) were obtained. The number, nature and grading distribution of pulmonary embolism were recorded. The iodine concentration (IC) and CT value of embolic lung tissue, contralateral healthy lung tissue and thoracic aorta at the same level were measured, meanwhile the normalized iodine concentration (NIC) was calculated. Results: A total of 402 emboli in 65 patients with APE were finally included. The diagnostic efficacy of CTPA, CTPA+iodine-based material decomposition images and CTPA+iodine-based material decomposition images +specral virtual virtual lung perfusion images for emboli improved successively, and the detection rates of grade 3 and 4 emboli were significantly better than those of single CTPA (P＜0.05). The results of quantitative analysis showed that compared with the healthy lung tissue, the CT value, IC and NIC of the embolized lung tissue on the 70 keV single-energy image of CTPA were significantly reduced, and the differences were highly statistically significant (P＜0.05). Conclusion: Spectral CT iodine quantitative parameters combined with virtual perfusion imaging can significantly improve the diagnostic accuracy of acute pulmonary embolism, especially in the diagnosis of pulmonary embolism in pulmonary segments, sub-segments and below.

Objective: To investigate the potential risk factors of tumor recurrence in patients with colorectal adenoma after endoscopic surgery. Methods: Patients who underwent endoscopic surgery for colorectal adenomas at the Digestive Endoscopy Center of the Affiliated Hospital of Putian University from January 1,2020 to December 31,2022 were selected. After 2 years of follow-up, they were divided intoadenoma recurrence group and adenoma non-recurrence group according to whether they relapsed after surgery. The information of the enrolled patients was collected, including age, gender, body mass index (BMI), total cholesterol, triglyceride, uric acid, number of adenomas, maximum diameter of adenomas, morphology (Yamada classification), pathological type, location and resection method. Univariate and multivariate Logistic regression analysis was used to analyze the risk factors of adenoma recurrence after endoscopic surgery for colorectal adenomas. Results: Among the 612 patients, 189 (30.88%) were in the adenoma recurrence group, and 423 (69.12%) were in the non-recurrence group. The analysis indicated that age, number of adenomas, maximum adenoma diameter, and histopathological type (all P＜0.05) were identified as risk factors for recurrence after endoscopic surgery for colorectal adenomas. Conclusion: Age, number of adenomas, maximum diameter of adenomas and pathological type are risk factors for recurrence of colorectal adenomas after endoscopic surgery. Based on these factors, clinicians can make more targeted follow-up plans, so as to take more scientific and reasonable measures in colonoscopy follow-up of patients after colorectal adenoma surgery.

Objective: To evaluate the diagnostic value of blood-derived exosomes carrying non-coding RNA in colorectal cancer by Meta-analysis, and to provide clinical basis for accurate diagnosis and treatment of colorectal cancer. Methods: Computer-based searches were conducted in databases including PubMed, Embase, and Web of Science to retrieve publicly published literatures on exosomes for colorectal cancer diagnosis from the establishment of each database up to April 10, 2024. Literature screening and data extraction were performed in accordance with the inclusion and exclusion criteria, and the quality of the included literatures was assessed using the QUADAS-2 scale. Software including Stata, Review Manager, and Meta-DiSc was used to analyze the data of the included literatures, and indicators of individual studies were summarized, such as sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), receiver operating characteristic (ROC) curve, and area under the curve (AUC). Subgroup analysis, sensitivity analysis, and the drawing of bivariate box plots were conducted to explore the sources of heterogeneity, and funnel plots were generated to detect publication bias. Results: A total of 12 literatures were included, covering 17 types of exosomal non-coding RNAs. The results of the Meta-analysis showed that the SEN, SPE, PLR, NLR, DOR, and AUC were 0.84 (95%CI: 0.80-0.88), 0.77 (95%CI: 0.71-0.82), 3.64 (95%CI: 2.97-4.45), 0.21 (95%CI:0.17-0.26), 17.60 (95%CI: 13.17-23.52), and 0.88 (95%CI: 0.84-0.90), respectively. After subgroup analysis, it was found that the sensitivity of exosomal LncRNA was 0.92 (95%CI: 0.75-0.98) and its AUC value was 0.92 (95%CI: 0.89-0.94), both of which were higher than those of other subgroups. Conclusion: Exosomes carrying non-coding RNAs have relatively high SEN and SPE, and are expected to become an accurate diagnostic tool for the detection of colorectal cancer.

Objective: To investigate the expression level and clinical significance of Hsa_circ_0000437 in the serum of gastric cancer (GC) patients. Methods: A total of 50 pathologically confirmed GC patients and 50 healthy controls were enrolled from the First Affiliated Hospital of Baotou Medical College between October 2022 and August 2023. Serum Hsa_circ_0000437 expression was detected by RT-qPCR, and the difference in expression between the two groups was analyzed by comparing Ct values. A receiver operating characteristic (ROC) curve was plotted, and the AUC was calculated to evaluate the diagnostic efficacy of Hsa_circ_0000437 for GC. Results: The relative quantitative results (2^^-ΔΔCt＞1) indicated that the expression level of Hsa_circ_0000437 in the serum of GC patients was significantly higher than that in healthy controls. ROC analysis showed an AUC of 0.816 (95%CI: 0.753-0.878) for diagnosing GC, with an optimal cutoff value of 1.034, corresponding to a sensitivity of 95.6% and a specificity of 60.0%. Conclusion: Hsa_circ_0000437 is highly expressed in the serum of GC patients and demonstrates good diagnostic performance, indicating significant clinical potential as a novel tumor biomarker for early diagnosis and screening of gastric cancer.

Objective: To explore the changes and clinical significance of electroencephalogram, homocysteine (Hcy), and 25-hydroxyvitamin D [25(OH)D] level during the treatment of children with epilepsy. Methods: A total of 160 children with epilepsy admitted to our hospital from January 2022 to January 2024 were retrospectively selected as the research objects. According to the recurrence, they were divided into recurrence group (n=26) and non-recurrence group (n=134). The interictal epileptiform discharges (IEDs) index and the levels of Hcy and 25(OH)D were compared between the two groups. IEDs index, Hcy and 25(OH)D levels were compared between the two groups. The correlation between IEDs index, Hcy, 25(OH)D levels and recurrence of children with epilepsy after 2 courses of treatment was analyzed. The predictive value of IEDs index, Hcy and 25(OH)D levels on epilepsy recurrence after 2 courses of treatment was analyzed. Results: On admission and after 2 courses of treatment, the IEDs index and Hcy level in the recurrence group were higher than those in the non-recurrence group, and the serum 25(OH)D level was lower than that in the non-recurrence group (P＜0.05). After 2 courses of treatment, IEDs index and serum Hcy level in children with epilepsy were positively correlated with their recurrence, and serum 25(OH)D level was negatively correlated with their recurrence (P＜0.05). After 2 courses of treatment, IEDs index and serum Hcy level were independent risk factors for epilepsy recurrence in children, and serum 25(OH)D level was an independent protective factor for epilepsy recurrence in children (P＜0.05). After 2 courses of treatment, the AUC of IEDs index combined with serum Hcy and 25(OH)D levels in predicting epilepsy recurrence was 0.799, and the Youden index was 0.599 (P＜0.05). Conclusion: The changes in electroencephalogram, homocysteine, and 25(OH)D levels during the treatment of children with epilepsy are significant, and are closely related to the recurrence of the disease. The combined detection of these indicators has certain reference value for predicting the recurrence of epilepsy in children.

Objective: To explore the effect of four thrombus indexes combined with Ca125 and HE4 detection in early diagnosis and invasive prediction of epithelial ovarian cancer(epithelial ovarian cancer, EOC). Methods: From June 2023 to August 2024, patients with epithelial ovarian cancer (EOC) who underwent the first comprehensive staged surgery and cytoreductive surgery in gynecology department of the Second Affiliated Hospital of Southern Anhui Medical College were retrospectively selected. Early EOC cases (stage Ⅰ and Ⅱ) were included in the non-metastatic group, and late EOC cases (stage Ⅲ and Ⅳ) were included in the metastatic group, and surgery was performed at the same time. The differences of thrombus, Ca125 and HE4 levels among the three groups were compared. The indexes of benign group, non-metastatic group and metastatic group were compared and analyzed, and the receiver operating characteristic curve (ROC) was drawn, and the area under curve (AUC) was calculated to evaluate the value of individual and combined detection of each index in early diagnosis and invasion prediction of epithelial ovarian cancer. Results: There were significant differences in the levels of four thrombus indexes, Ca125 and HE4 among the three groups (P＜0.05). Compared with the non-metastasis group, the combined detection of Ca125+HE4+ four thrombus indexes in the benign group had the higher specificity and sensitivity in the early diagnosis of EOC, and the AUC was 0.775. Compared with the non-metastatic group and the metastatic group, the combined detection of Ca125+HE4+four thrombus indexes had the highest specificity and sensitivity in the prediction of invasion of EOC, with an AUC of 0.950. Conclusion: The detection of four thrombus indexes combined with tumor markers has high sensitivity and specificity in the early diagnosis and invasive prediction of EOC.

Objective: To explore the changes and clinical significance of serum mucin 5AC (MUC5AC), cysteinyl leukotrienes (CysLTs), and interleukin-35 (IL-35) levels in children with bronchiolitis, in order to provide reference for early clinical intervention. Methods: A total of 82 children with bronchiolitis who were treated in our hospital from April 2022 to June 2024 were selected as the study group, and 82 healthy children were selected as the control group. The levels of serum MUC5AC, CysLTs and IL-35 in the two groups and children with different disease severity were compared. The correlation between the levels of serum MUC5AC, CysLTs and IL-35 and the disease severity was analyzed. The levels of serum MUC5 AC, CysLTs and IL-35 in children with secondary asthma were compared. The effects and diagnostic value of serum MUC5AC, CysLTs and IL-35 levels on secondary asthma in children with bronchiolitis were analyzed. Results: Compared with the control group, the levels of serum MUC5AC and CysLTs in the study group were higher, and the level of serum IL-35 was lower (P＜0.05). Comparison of serum MUC5AC and CysLTs levels at admission in children with different disease severity: mild group＜moderate group＜severe group; comparison of serum IL-35 level: mild group>moderate group>severe group (P＜0.05). Spearman correlation analysis showed that the levels of serum MUC5AC and CysLTs at admission were positively correlated with the severity of bronchiolitis (r=0.756, 0.783, P＜0.05), and the level of serum IL-35 was negatively correlated with the severity of bronchiolitis (r=-0.725, P＜0.05). Compared with children without secondary asthma, the levels of serum MUC5AC and CysLTs were higher and the level of IL-35 was lower in children with secondary asthma on admission (P＜0.05). Serum MUC5AC and CysLTs levels were risk factors for secondary asthma in children with bronchiolitis, and serum IL-35 was a protective factor for secondary asthma in children with bronchiolitis (P＜0.05). The diagnostic AUC of serum MUC5AC, CysLTs and IL-35 levels at admission for secondary asthma in children with bronchiolitis was 0.795, 0.832 and 0.856, respectively, and the combined diagnostic AUC was 0.927. Conclusion: The levels of serum MUC5 AC, CysLTs and IL-35 are closely related to the severity of bronchiolitis in children, which provides a reference for early clinical evaluation of the disease and secondary asthma, so as to formulate corresponding intervention treatment plans and improve the prognosis.

Objective: To investigate the diagnostic value of contrast-enhanced CT texture analysis in differentiating thymoma and high-density thymic cysts. Methods: The complete data of 123 patients with thymic tumors confirmed by surgery and pathology were retrospectively analyzed, including 88 patients with thymoma and 35 patients with high-density thymic cysts. All patients were randomly divided into training group (n=87) and validation group (n=36) according to the ratio of 7∶3. Using 3D Slicer, two radiologists manually delineated the region of interest (ROI) along the edge of the target lesion in plain, arterial, and venous images, and extracted the texture features. Intraclass correlation coefficient (ICC) was used to evaluate the consistency of texture features extracted by 2 physicians. Least absolute shrinkage and selection operator (LASSO) regression was applied for feature dimensionality reduction and selection, followed by logistic regression modeling. A radiomics score (Rad-score) was calculated by weighting selected features based on their coefficients. Receiver operating characteristic (ROC) curve analysis was used to evaluate diagnostic performance, and the area under curve (AUC) was calculated. Finally, decision curve analysis (DCA) was employed to validate clinical net benefits across threshold probabilities. Results: The agreement of the texture features extracted by 2 physicians was good (ICC＞0.75). The AUC for the differential diagnosis of thymoma and high-density thymic cysts in the training set and validation set was 0.87 and 0.90. The AUC of plain, arterial, venous, plain＋arterial, plain＋venous, arterial＋venous, and three-phases were 0.90, 0.91, 0.95, 0.94, 0.98, 0.95 and 0.93 in the training set, while in the validation set, the AUC were 0.94, 0.95, 0.97, 0.94, 0.96, 0.97 and 0.96. The results of the DCA analysis showed that the plain＋venous phase model had a good clinical benefit. Conclusion: Based on the combined model of plain＋venous stage in contrast-enhanced CT texture analysis has relatively high value in the differential diagnosis of thymoma and high-density thymic cyst.

Objective: To investigate the correlation between hyperoxaluria (oxaluria≥45 mg/d) and gender, age and metabolic diseases (hypertension, diabetes), providing evidence for the prevention and management of urinary calculi. Methods: The clinical data of 200 patients with urinary calculi admitted to Anyang Sixth People′s Hospital from April 2024 to April 2025 were retrospectively analyzed. According to the level of oxalic acid urine, the patients were divided into hyperoxaluria group (n=102) and non-hyperoxaluria group (n=98). The gender, age, hypertension and diabetes data of the two groups were collected. Univariate analysis was performed by chi-square test, and binary logistic regression analysis was performed on the factors with significant differences. Results: There were significant differences were observed between the hyperoxaluria and non-hyperoxaluria groups in gender (P＜0.001) and diabetes prevalence (P=0.024), while age and hypertension showed no significant associations(P＞0.05). Multivariate analysis revealed that males had a significantly higher risk of hyperoxaluria than females (OR=3.534, 95%CI: 1.956-6.385), while diabetic patients had a lower risk than non-diabetic patients (OR=0.505, 95%CI: 0.280-0.913). The proportion of hyperoxaluria in young, middle-aged and elderly groups was similar (51.4%, 50.0%, 51.6%). Conclusion: Gender and diabetes are independent influencing factors for hyperoxaluria, with males and non-diabetic individuals at higher risk, whereas age and hypertension showed no significant association. Clinically, male patients should prioritize oxaluria metabolism monitoring and dietary interventions, while diabetic patients require integrated management of other metabolic abnormalities to reduce the risk.