Objective: To investigate the potential mechanisms of Prunella vulgaris for the treatment of diabetes mellitus (DM) through network pharmacology and molecular docking methods. Methods: The active ingredients of Prunella vulgaris were screened by TCMSP database, the active ingredient targets of Prunella vulgaris were predicted from STP database, and the related targets of DM were screened in TTD, OMIM, DisGENET and DrugBank disease databases. STRING was used to construct the protein interaction network, Cytoscape 3.8.0 and Omicshare were used for topology analysis, GO function and KEGG pathway enrichment, and the affinity between the active components of Prunella vulgaris and the key targets was verified by molecular docking. Results: Twenty active ingredients and 167 disease targets of Prunella vulgaris were obtained, and and 57 core targets such as serine/threonine-protein kinase 1 (AKT1) were found by network topology analysis. KEGG pathway was enriched in proteoglycans, advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE), C-type lectin receptors and other metabolic pathways in diabetic complications to exert the therapeutic effect of Prunella vulgaris on DM. Molecular docking showed that the core components of spinasterol, morin, stigmast-7-enol, vitamin K, β-sitosterol had good binding activity with amyloid precursor protein (APP), AKT1, interleukin 6 (IL-6) and other targets. Conclusion: Prunella vulgaris mainly mediates phosphatidylinositol-4 through spinasterol, morin, stigmast-7-enol, vitamin K, β-sitosterol and stigmasterol. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), AKT1, mitogen-activated protein kinase 3 (MAPK3), IL-6, APP and other targets regulate proteoglycan and C-type lectin receptor signaling pathways, and play a role in regulating glucose homeostasis and glucose uptake, thereby improving the symptoms of DM and complications.

Objective: To investigate the relationship between ABCG2 ( rs2231142 ) allele distribution and hyperuricemia (HUA) in men in Inner Mongolia. Methods: A case-control study was conducted to select 408 males who underwent physical examination in the physical examination center of the Fourth Hospital of Baotou from September 2023 to April 2024, including 202 cases in HUA group and 204 cases in non-HUA group. KASP-competitive allele-specific PCR was used to detect gene polymorphism. The χ² test was used for comparison between allele groups, and the relationship between allele and male HUA was analyzed by Logistic regression. Results: The distribution frequencies of alleles G and T of ABCG2 (rs2231142) locus in the HUA group were 65.3% and 34.7% respectively, while those in the non-HUA group were 71.8% and 28.2% respectively. There was a difference in the frequency distribution between the two groups (P=0.047). The minor allele T was associated with HUA in men, and compared with men carrying allele G, men carrying allele T had an increased risk of HUA (OR=1.358, 95%CI: 1.005-1.836). Stratified analysis of age showed that minor allele T was associated with the occurrence of HUA in men aged 40-60 years old, which was the influencing factor of HUA in men of this age group (OR=1.477, 95%CI:1.003-2.173). Conclusion: In the male population in Inner Mongolia, the T allele of ABCG2 (rs2231142) locus presents a relatively higher proportion in individuals with HUA. The minor allele T is associated with an increased risk of HUA in local males, and this risk association is more significant in men aged 40 to 60 years.

Objective: To investigate the damage of neodymium oxide (Nd₂O₃) exposure on mitochondria of astrocytes (AST) and the role of tunneling nanotubes (TNTs) in it. Methods: AST was extracted from SD rats within 3 days of birth, and the specific expression of GFAP was identified by immunofluorescence. CCK8 kit was used to detect the cell survival rate after neodymium oxide exposure. DCFH-DA probe was used to detect intracellular reactive oxygen species; MitoSOX Red was used to detect the reactive oxygen species in mitochondria. Mitochondrial membrane potential was detected by Rhodamine 123. The live cell staining markers F-actin, β-tubulin and mitochondria were used to observe the structure, quantity and mitochondrial transmission of TNTs. Results: The extracted astrocytes specifically expressed GFAP; the optimal exposure dose and time were determined by cell viability testing to be 10 μg/mL Nd₂O₃ and 12 hours. After Nd₂O₃ exposure, the levels of intracellular reactive oxygen species and mitochondrial reactive oxygen species were significantly increased, and the mitochondrial membrane potential was decreased; the structure of TNTs in AST-AST was dominated by F-actin; and after Nd₂O₃ exposure, the number of TNTs in ASTs was increased, while TNTs mediated mitochondrial transmission in ASTs after Nd₂O₃ exposure. Conclusion: The increased level of oxidative stress in AST caused by Nd₂O₃ has been demonstrated to trigger mitochondrial damage and to mediate intercellular mitochondrial transmission via TNTs.

眩晕作为一种常见的临床病症,近年在世界范围内呈多发递增趋势,患者的日常生活和工作受到了较大影响。医学界对眩晕的研究已有诸多进展,然而,鉴于眩晕的复杂病因和发病机制,传统单一医学模式在治疗上往往难以取得满意的效果。因此,探索一种融合中西医优势的眩晕治疗新模式,不仅具有重要的临床实践价值,也能丰富眩晕病治疗理论体系。本文以中西医结合为视角,系统分析眩晕的病因病机,探讨中西医治疗眩晕的理论基础及临床应用,旨在为眩晕患者提供一种更为全面有效的治疗方案,对于推动中西医结合在眩晕病治疗领域的应用具有重要的指导意义。

Cardiovascular disease is one of the leading causes of death in the world. Serum uric acid level and high-density lipoprotein cholesterol level are two important factors affecting cardiovascular health. Recent studies have found that serum uric acid to high-density lipoprotein cholesterol ratio ( UHR ) can better reflect the risk and prognosis of cardiovascular disease. This article reviews the clinical application value of UHR in cardiovascular diseases in recent years, and provides reference for clinical diagnosis and treatment.

Objective: To explore the effects of family dietary behavior and dietary structure on overweight/obesity in children aged 6-12 years in Huangdao District of Qingdao City, and to provide a basis for formulating regional intervention strategies. Methods: From October 2023 to February 2024, children aged 6-12 years old in Huangdao District of Qingdao City who came to Qingdao Huangdao District Central Hospital for physical examination were selected as the research objects, and the data were collected by questionnaire survey. The questionnaire included general demographic indicators, basic physical indicators, family factors and dietary survey. Results: A total of 560 valid questionnaires were obtained, with overweight accounting for 17.1%(95/560) and obesity accounting for 22.1%(124/560 ). The proportion of boys in overweight and obesity groups was significantly higher than that in normal group(P＜0.05). Among them, the proportion of mothers with college degree or above and the proportion of nuclear families in the overweight group were higher than those in the normal group(P＜0.05). In terms of family eating behavior, the number of eating out ≥2 times and the number of meals before bedtime in the overweight and obese group were significantly higher than those in the normal group(P＜0.05); the proportion of regular breakfast decreased, and the proportion of regular breakfast in the normal group was significantly higher than that in the obese group(P＜0.05); the sleep duration of the three groups was insufficient, and the number of children with sleep time >10 h per night on the rest day in the obese group was significantly lower than that in the normal group(P＜0.05). In terms of dietary factors, compared with the normal group, the average weekly intake frequency of pancakes/deep-fried dough sticks/deep-fried dough sticks, buns/dumplings/wontons in cereals, processed meat products in meat, carbonated drinks, biscuits/cakes and puffed food in other categories in the overweight and obese groups were higher(P＜0.05). The average weekly intake frequency of tubers in the obese group was significantly lower than that in the normal group, while the intake frequency of livestock meat and Western fast food was higher than that in the normal group(all P＜0.05). Conclusion: The proportion of overweight and obesity in children in Huangdao District of Qingdao City is relatively high. In addition to being related to their own gender, it is also closely related to the type of core family structure, the frequency of eating out, pre-bedtime meals, lack of sleep and high-calorie dietary intake. Interventions should focus on changing family lifestyles and cultivating children′s healthy dietary habits.

Objective: To explore the effect of miR-204-5p on the proliferation, migration and invasion of bladder cancer cells by specifically regulating the expression level of TCF12, and to further reveal its mechanism. Methods: The expression levels of miR-204-5p in bladder cancer cells and human urothelial cells, as well as bladder cancer tissues and adjacent tissues were detected by qRT-PCR. CCK-8, Transwell and flow cytometry were used to verify the effect of miR-204-5p on bladder tumor cells. The dual luciferase assay was used to verify the targeting relationship between miR-204-5 p and TCF12. Western-blot and qRT-PCR were used to detect the regulatory effect of miR-204-5p on the expression of TCF12. Results: The expression of miR-204-5p was significantly up-regulated in bladder cancer tissues and cell lines (P＜0.05). The overexpression of miR-204-5p was confirmed to promote the progression of bladder cancer in vitro (P＜0.05). Studies had confirmed that TCF12 was a potential target gene of miR-204-5p, and down-regulation of TCF12 by miR-204-5p promoted the proliferation, migration and invasion of bladder cancer cells. Overexpression of TCF12 could also reverse the effect of miR-204-5p overexpression on bladder cancer cells. Conclusion: miR-204-5p may promote the proliferation, migration and invasion of bladder cancer cells by targeting TCF12 and down-regulating its expression level. Targeting miR-204-5p / TCF12 may provide a potential therapeutic strategy for bladder cancer.

Objective: To explore the application value of spectral CT iodine quantitative parameters and virtual lung perfusion imaging in the diagnosis of acute pulmonary embolism (APE). Methods: The clinical data of patients with suspected APE who underwent GE spectral CT pulmonary angiography were retrospectively collected. Monoenergetic images, iodine-based material decomposition images and virtual lung perfusion images of 70 keV CT pulmonary angiography (CTPA) were obtained. The number, nature and grading distribution of pulmonary embolism were recorded. The iodine concentration (IC) and CT value of embolic lung tissue, contralateral healthy lung tissue and thoracic aorta at the same level were measured, meanwhile the normalized iodine concentration (NIC) was calculated. Results: A total of 402 emboli in 65 patients with APE were finally included. The diagnostic efficacy of CTPA, CTPA+iodine-based material decomposition images and CTPA+iodine-based material decomposition images +specral virtual virtual lung perfusion images for emboli improved successively, and the detection rates of grade 3 and 4 emboli were significantly better than those of single CTPA (P＜0.05). The results of quantitative analysis showed that compared with the healthy lung tissue, the CT value, IC and NIC of the embolized lung tissue on the 70 keV single-energy image of CTPA were significantly reduced, and the differences were highly statistically significant (P＜0.05). Conclusion: Spectral CT iodine quantitative parameters combined with virtual perfusion imaging can significantly improve the diagnostic accuracy of acute pulmonary embolism, especially in the diagnosis of pulmonary embolism in pulmonary segments, sub-segments and below.

Objective: To analyze the epidemiological characteristics of hepatitis E virus (HEV) infection among aquaculture population in Baotou City, and to evaluate the infection rate of different age groups, so as to provide data support for the prevention and control of hepatitis E in the aquaculture population. Methods: Blood samples of aquaculture population (pigs, cattle, sheep) in Baotou City from July 2023 to July 2024 were collected, and HEV-IgG antibodies in serum were detected by ELISA. Grouped according to the age, and the positive rate of infection in each age group was counted. Results: A total of 679 samples were collected. The positive infection rates of each age group were as follows: the group from 0 to≤20 years was 3.23%,＞20 to≤30 years was 10.87%,＞30 to≤40 years was 14.93%, ＞40 to≤50 years was 41.28%, ＞50 to≤60 years was 50.00%,＞60 to≤70 years was 34.52%, ＞70 to≤80 years was 68.57%, ＞80 to≤90 years was 60.00%. The results of the chi-square test showed that the positive infection rates of the groups ＞30 to≤40 years old,＞40 to≤50 years old, ＞50 to≤60 years,＞70 to≤80 years, and＞80 years to≤90 years were significantly different compared with those of other age groups (P＜0.001). Conclusion: The positive rate of HEV infection in Baotou breeding population is higher, especially in the population over 40 years old, indicating that the aquaculture population may face a higher risk of HEV exposure, and it is necessary to strengthen the prevention and control of this virus.

Objective: To observe the morphological characteristics of the glutamatergic projection pathway from the ventrolateral periaqueductal gray (vlPAG) to the parafascicular nucleus of the thalamus (PF) in mice. Methods: Firstly, the expression of vesicular glutamate transporter 2 (vGluT2)-positive neurons in the vlPAG was observed by retrogradely trans-monosynaptic labeling with the retrograde virus (RV) in vGluT2-Cre mice. Then fluorescence in situ hybridization (FISH) was used to observe RV and vGluT2-positive neurons. Results: (1)After injecting RV into the PF of vGluT2-Cre mice, RV retrograde labeled neurons were observed in the rostral and caudal segments of the vlPAG. (2)By FISH staining, it was observed that vGluT2-positive neurons and RV were co-labeled in vlPAG, and the number of double labels accounted for 33.2±8.7% of RV. Conclusion: The vGluT2-positive neurons in the vlPAG sent fiber projections to the PF, and form monosynaptic connections with vGluT2-positive neurons in the PF.

Objective: To explore the mechanism by which pressure affects osteogenesis of dura mater cells through the FAK-PI3K-AKT signaling pathway. Methods: After osteogenic induction of dura mater cells, the morphological changes of the cells were observed under an inverted microscope. Alizarin red staining and alkaline phosphatase staining were used to evaluate the formation of calcium nodules. The mRNA expression levels of focal adhesion kinase (FAK), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (AKT) under pressure intervention were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The expression levels of p-AKT, PI3K, and p-FAK proteins in the FAK-PI3K-AKT signaling pathway under pressure intervention were detected by Western blot. Results: After osteogenic induction, the morphological characteristics of dura mater cells changed significantly, gradually transforming from fusiform to short fusiform or polygonal, with elongated and flattened cell bodies and significantly increased cell and nuclear volumes. The results of alizarin red staining and alkaline phosphatase staining showed that the cell staining was significantly deepened after osteogenic induction. Under pressure stimulation, the mRNA levels of AKT, PI3K, and FAK in dura mater cells and the protein expression levels of p-AKT, PI3K, and p-FAK were all increased. The expression levels of osteogenesis-related proteins osteocalcin (OCN) and alkaline phosphatase (ALP) were significantly upregulated. Conclusion: After osteogenic induction of dura mater cells, the number of osteogenic nodules increased over time. The mechanism may be achieved by activating the FAK-PI3K-AKT signaling pathway, thereby increasing the expression of osteogenesis-related proteins.

Objective: To explore the effect and mechanism of cynomorium songaricum flavonoids (CSF) on senescence-accelerated mice prone 8 (SAMP8). Methods: Thirty 7-month-old male SAMP8 mice were selected and randomly divided into control group, cynomorium songaricum flavonoids group, and donepezil group. The SAMP8 mice in the cynomorium songaricum flavonoids group were given cynomorium songaricum flavonoids 50 mg/(kg·d) by gavage for 20 days, and the donepezil group was given donepezil 0.71 mg/(kg·d) by gavage for 20 days. After administration, the Morris water maze was used to evaluate the cognitive function, and Nissl staining was used to observe the morphology and count of hippocampal pyramidal cells. The protein expression levels of NADPH: quinone oxidoreductase-1 (NOQ1), nuclear factor e2 related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in hippocampus were determined by Western blotting. The activity of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in serum were measured by ELISA. Results: Compared with the control group, the distance and escape latency of the mice in the cynomorium songaricum flavonoids were decreased, and the percentage of the number of crossing the platform and the time of the target quadrant were increased (P＜0.05). Compared with the control group, the expression of Nrf2, Keap1 and NOQ1 protein in the hippocampus of the mice in the cynomorium songaricum flavonoids group and donepezil group was increased (P＜0.05). Compared with the control group, the activity of SOD and GSH-Px in the serum of mice in the cynomorium songaricum flavonoids group was increased (P＜0.05), and the content of MDA was decreased (P＜0.05). Conclusion: Cynomorium songaricum flavonoids can improve cognitive dysfunction in SAMP8 mice, and its mechanism may be related to regulating the Nrf2 Keap1 pathway to inhibit oxidative stress.

Objective: To explore the effect of nursing management based on Assessment-Communication-Monitoring-Patient-Environment (ACMPE) combined with core stable muscle group training on postoperative rehabilitation of lumbar fracture. Methods: A total of 104 patients with lumbar fractures admitted to Ziyun Miao and Buyi Autonomous County People's Hospital from March 2023 to May 2024 were selected. and they were divided into an intervention group and a control group. The control group received routine rehabilitation, whereas the intervention group received additional ACMPE-based nursing management combined with core stable muscle group training. The Quebec Back Pain Disability Scale (QBPDS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA), activities of daily living (ADL) immediately after operation and 7 d, 30 d and 90 d after operation, and rehabilitation satisfaction were compared between the two groups. Results: There was no significant difference in QBPDS, ODI, JOA and ADL scores between the two groups immediately after operation (P＞0.05). The QBPDS and ODI scores of the intervention group were lower than those of the control group at 7 d, 30 d and 90 d after operation, and the JOA and ADL scores were higher than those of the control group (P＜0.05). At 90 days after operation, the rehabilitation satisfaction rate of the intervention group was 94.23%, which was higher than 80.77% of the control group (P＜0.05). Conclusion: ACMPE-based nursing management combined with core stable muscle group training can effectively relieve pain, improve lumbar function, improve patients' daily living ability and satisfaction with rehabilitation.

Professor Bai Changchuan inherited the system of syndrome differentiation based on prescriptions and syndromes, the doctrines of Zhongjing, and the achievements of famous scholars throughout history. On the basis of Li Gao's academic thought of "internal injury to the spleen and stomach" among the Four Great Masters of the Jin and Yuan Dynasties, he integrated and mastered it.Focusing on the current changes in the natural environment, social factors, human lifestyles and dietary structures, the types and syndrome types of diseases also change accordingly.In the process of clinical diagnosis and treatment experience and reflection, a systematic theory of "Indigestion of Spleen and Stomach, Caucusing Various Diseases" has been formed in clinical practice.Professor Bai Changchuan discovered during his clinical treatment of heart failure patients that the theory of "Indigestion of Spleen and Stomach" is closely related to the onset and development of heart failure. He achieved excellent therapeutic effects in treating heart failure based on the spleen and stomach theory.This article aims to explore Professor Bai Changchuan's experience in treating chronic heart failure by applying the academic thought that "Indigestion of Spleen and Stomach, Caucusing Various Diseases", providing a theoretical basis for the subsequent standardized treatment of heart failure.

Objective: To explore the mechanism of Trollius chinensis Bunge in the treatment of chronic sinusitis by network pharmacology and molecular docking. Methods: Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and other databases were used to screen the active ingredients and potential targets in Trollius chinensis Bunge. GeneCards and other databases were used to search for disease-related targets; the compound target-disease Venn diagram was constructed, and the intersection target between drug target and disease target was obtained. Cytoscape 3.9.1 software was used to draw the drug-component-target-disease network diagram. The PPI network diagram of protein-protein interaction was constructed by STRING database and Cytoscape. R4.2.1 software clusterProfiler package was used to perform gene ontology (GO) function and kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis, and Cytoscape was used to construct a drug-component-target-pathway network diagram. Molecular docking of key active ingredients and core targets was performed using AutoDockTools. Results: Through database screening, 14 active ingredients, 507 active ingredient targets, 829 disease-related targets and 160 common targets were obtained. Quercetin, acacetin, β-sitosterol, dihydroquercetin and luteolin were the core components of Trollius chinensis Bunge in the treatment of chronic sinusitis. Protein interaction network analysis showed that the core targets may be through signal transducer and activator of transcription 3 (STAT3), the tumor necrosis factor (TNF), interleukin-6 (IL-6), TP53, AKT1, SRC and other six core targets. GO and KEGG enrichment analysis showed that STAT3, TNF, IL-6 and other signaling pathways played an anti-inflammatory role. The results of molecular docking showed that the core components of Trollius chinensis had good binding ability with the core targets. Conclusion: Quercetin, acacetin, β-sitosterol and other active ingredients in Trollius chinensis Bunge may regulate STAT3, IL-6, TNF, TP53, AKT1, SRC and other targets to regulate multiple signaling pathways, reduce the secretion of inflammatory factors, regulate the occurrence and development of inflammation, so as to play a role in the treatment of chronic sinusitis.

Objective: To investigate the clinical efficacy of Yaotong prescription in the treatment of lumbar disc herniation. Methods: A total of 100 patients with lumbar disc herniation admitted from January 2020 to November 2024 were selected, and the grouping design of subjects was completed by drawing lots. The control group was treated with conventional conservative therapy, while the treatment group was treated with Yaotong prescription on the basis of conservative treatment. The efficacy was evaluated by Visual Analogue Scale (VAS), Japanese Orthopaedic Association score (JOA) and Oswestry Dysfunction Index (ODI), and adverse reactions were monitored. Results: The total effective rate of the treatment group (94.00%) was significantly higher than that of the control group (68.00%) (P＜0.05). After treatment, the VAS score (treatment group 3.20±0.80 vs. control group 5.60±1.20) and ODI index (treatment group 18.50±3.10 vs. control group 29.80±4.50) of the two groups were significantly decreased, and the JOA score (treatment group 24.70±2.30 vs. control group 18.90±2.10) was significantly increased (P＜0.05), while compared with the control group, the treatment group showed more significant improvement in all indicators (P＜0.05), and no serious adverse reactions were observed. Conclusion: Yaotong prescription can effectively relieve the pain symptoms of patients with lumbar disc herniation, improve their functional activities, and has a definite clinical effect.

Objective: To systematically evaluate the risk factors for neonatal hypoglycemia in infants born to mothers with gestational diabetes mellitus (GDM). Methods: Electronic searches were performed in CNKI, Wanfang Data, VIP, SinoMed, PubMed, Embase, Web of Science, and the Cochrane Library to identify studies on risk factors for neonatal hypoglycemia in GDM offspring, with the search period spanning from database inception to June 2025. Literature screening, data extraction, and risk of bias assessment of included studies were independently conducted by two researchers. Meta-analyses were performed using Stata 17.0 and RevMan 5.4 software. Results: A total of Thirty-four retrospective case-control studies were included, with a total sample size of 9 679 participants. Meta-analysis findings revealed that pre-pregnancy overweight or obesity, preterm birth, low birth weight, neonatal hypothermia, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), advanced glycation end products (AGEs), antenatal BMI, poor antenatal glycemic control, cesarean delivery, advanced maternal age, neonatal asphyxia, inappropriate feeding practices, gestational hypertension, insufficient lactation, fructosamine, higher neonatal birth weight, and macrosomia were significant correlates (P＜0.001). Conclusion: Pre-pregnancy overweight or obesity, elevated HbA1c, increased antenatal BMI, neonatal asphyxia, insufficient lactation, elevated fructosamine, high neonatal birth weight, macrosomia, preterm birth, low birth weight, neonatal hypothermia, elevated AGEs, poor antenatal glycemic control, cesarean delivery, advanced maternal age, gestational hypertension, and inappropriate feeding practices may constitute risk factors for neonatal hypoglycemia in infants born to mothers with gestational diabetes mellitus.

Objective: To investigate the expression changes of thioredoxin (Trx) system in tumor necrosis factor-α (TNF-α) -induced psoriasis-like cell model, and to reveal its potential role in inflammation and oxidative damage of cell model. Methods: Human keratinocyte HaCaT cells were induced with TNF-α to establish a psoriasis-like inflammatory cell model. Cells were divided into a control group and a TNF-α model group. The CCK-8 assay was used to detect cell proliferation rate, ELISA was applied to measure inflammatory cytokine expression and cellular reactive oxygen species (ROS) levels, and Western blot was performed to analyze the protein expression of thioredoxin-1 (Trx-1) and thioredoxin reductase (TrxR). Results: Compared with the control group, the expression of TrxR in the TNF-α model group was decreased (P＜0.05); the expression of Trx-1 showed a downward trend, but there was no statistical significance; cell proliferation was increased (P＜0.001); the expression levels of inflammatory mediators TNF-α, IL-17 and IL-22 were increased (P＜0.001); the level of ROS was increased (P＜0.001). Conclusion: TNF-α can induce the decrease of TrxR expression in human epidermal keratinocytes, and increase the proliferation, inflammation and oxidative stress of epidermal keratinocytes, suggesting that abnormal expression of Trx system may be involved in TNF-α-induced psoriasis-like oxidative-inflammatory injury process.

Objective: To investigate the clinical efficacy of Dayuanyin Huazhu decoction combined with calcium dobesilate in the treatment of patients with non-proliferative diabetic retinopathy (NPDR). Methods: From August 2021 to October 2022, 50 patients (100 eyes) diagnosed with non-proliferative diabetic retinopathy in the Department of Ophthalmology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology were selected. According to the random number remainder grouping method, they were divided into western medicine control group (group A, simple oral administration of western medicine calcium dobesilate capsules, 25 cases with 50 eyes) and combined medication study group (group B, oral administration of Dayuanyin Huazhuo decoction combined with calcium dobesilate capsules, 25 cases with 50 eyes). The changes of blood glucose (fasting blood glucose, glycosylated hemoglobin) before and after 12 weeks of treatment, best corrected distant vision, number of fundus microangiomas, bleeding and exudation area, and TCM syndrome scores were compared between the two groups were observed and recorded. Results: During the medication period, the blood glucose control of the subjects remained stable. After 12 weeks of treatment, the overall effective rates of best corrected visual acuity (BCVA) for Group A and Group B were 72.00% and 80.00%, respectively; the overall effective rates for improvement in fundus symptoms (including the number of microaneurysms, bleeding, and area of exudation) were 68.00% and 80.00%, respectively, with Group B showing significantly better results than Group A (P＜0.05). The overall effective rates of traditional Chinese medicine symptom efficacy for Group A and Group B were 64.00% and 84.00%, respectively, also indicating Group B performed better than Group A (P＜0.05). The decrease in fasting blood glucose and glycated hemoglobin levels in Group B is significantly greater than that in Group A (inter-group comparison for fasting blood glucose P=0.0058, inter-group comparison for glycated hemoglobin P=0.035).Group B outperformed Group A in improving fundus lesions, vision, fasting blood glucose, glycated hemoglobin, and traditional Chinese medicine symptom scores (P＜0.05). Conclusion: The combination of traditional Chinese medicine Da Yuan Drink for clearing turbidity and the Western medicine calcium p-hydroxybenzenesulfonate has shown good efficacy in the treatment of NPDR, and it is worth promoting in clinical applications.

Objective: To explore the impact of nasogastric fixation of the Sengstaken-Blakemore tube for hemostasis method on the efficacy, adverse reactions and anxiety of patients with liver cirrhosis and upper gastrointestinal bleeding. Methods: A total of 77 inpatients with upper gastrointestinal bleeding due to liver cirrhosis admitted to the East District of Baotou Central Hospital from January 2017 to June 2024 were selected. They were divided into Group A (26 inpatients) using nasogastric fixation of the Sengstaken-Blakemore tube for hemostasis, Group B (26 inpatients) using traditional suspension fixation of the Sengstaken-Blakemore tube for hemostasis, and Group C (25 inpatients) using medication alone for hemostasis. Patients in group A and group B were treated with the same drug as group C at the same time. The effects of anxiety symptoms (Hamilton Anxiety Scale), catheterization and adverse reactions before and after treatment were compared between group A and group B, as well as the clinical efficacy and hemostatic effect of the three groups. Results: After treatment, the anxiety symptom of group A was significantly lower than that of group B (P＜0.05). There was no significant difference in hemostatic efficiency between group A and group B, but it was higher than that in group C (P＜0.05). There was no significant difference in the success rate of one-time catheterization between group A and group B. The average catheterization time of group A was 14.38±1.92, which was significantly lower than that of group B (P＜0.05). The incidence of intolerance, chest tightness, postural limitation discomfort, and nasal mucosal injury in group A were 30.80%, 15.40%, 26.90%, and 23.10%, respectively, which were significantly lower than those in group B (P＜0.05). Conclusion: Compared to the traditional suspension fixation of the Sengstaken-Blakemore tube for hemostasis, the nasogastric fixation of the Sengstaken-Blakemore tube for hemostasis is convenient and simple, improves the patient's comfort, reduces the anxiety symptoms, and reduces the incidence of complications. And compared with the simple drug hemostasis effect, it is suitable for promotion and application in primary hospitals.