Wnt蛋白家族属于一类具有高度保守半胱氨酸残基的分泌性脂质修饰糖蛋白,其通路是一组高度保守的信号转导通路,能够介导多种生理和病理过程,如参与调控细胞增殖、分化、凋亡、免疫与应激、炎症和纤维化。目前认为Wnt信号通路包括三个分支:经典Wnt信号通路,即Wnt/β-Catenin信号通路;Wnt/PCP通路;Wnt/Ca²⁺通路。Wnt/β-catenin信号途径在心、肝、肺、肾等器官纤维化等病理生理过程中均发挥了重要作用。越来越多的证据表明,Wnt/β-catenin信号通路在糖尿病肾病(diabetic nephropathy, DN)的进展中意义重大。本文就Wnt/β-catenin在系膜细胞凋亡、上皮间充质转变(epithelial mesenchymal transition, EMT)、DN条件下足细胞功能障碍、小管EMT和肾纤维化中的作用进行综述。此外,还介绍了这一过程所涉及的分子机制。这一信息为Wnt/β-catenin保护肾脏损伤和延缓DN进展提供了一个新的分子靶点。

Objective: To study the anti-nonalcoholic steatohepatitis mechanism of total flavonoids from Scabiosa comosa by network pharmacology. Methods: Based on the TCMSP database and literature reports, the main active components of total flavonoids from Scabiosa comosa were obtained. The Swiss Target Prediction server was used to predict the target of its active ingredients according to the reverse pharmacophore matching method, and the targets for improving NASH were screened out through databases such as Genecards, OMIM and Disgenet. The potential targets of drug targets and disease targets were used to make the Venn diagram. The Cytoscape software was used to construct the ' active ingredient-target ' network diagram. The STRING platform was used to construct the protein interaction network. The DAVID database and ClueGO plug-in were used for GO enrichment analysis and KEGG pathway analysis. Results: A total of 43 active components and 439 targets of total flavonoids were screened. The main active components in the network were ononin, camphene -3-O- rutinoside, isorhamnetin, quercetin, luteolin, eupatorium odoratum, etc. The key targets in the protein interaction network were TNF, AKT1, TP53, VEGFA, IL1B, etc. GO enrichment analysis involved 503 biological processes, 54 cellular components and 120 molecular functions. KEGG pathway enrichment analysis screened the top 20 related pathways, mainly acting on VEGF signaling pathway, PPAR signaling pathway, estrogen signaling pathway and so on. Conclusion: The flavonoid components from Scabiosa comosa can play a role in the treatment of nonalcoholic steatohepatitis through multiple targets and multiple pathways. The results provide a scientific basis for further study of the role of Scabiosa comosa in the field of anti-nonalcoholic steatohepatitis.

铅是一种可以通过呼吸道、消化道和皮肤接触等途径进入体内并蓄积产生毒性的非必需金属,可以对人体的多个系统造成损害,如肾脏、肝脏、神经、血液、生殖、胃肠道等,对肠道菌群也会产生影响。儿童时期正是快速生长发育阶段,是建立肠道微生物群的关键时期,因此儿童受铅暴露的毒性影响更加明显。本文综述了铅对不同动物模型及人的肠道屏障、菌群影响的相关研究成果,并重点强调了铅对儿童肠道的毒性作用。此外,本文分析了改善肠道屏障及菌群的研究,进一步总结了目前通过益生菌防治铅中毒可行和有效的策略。

糖尿病(diabetes mellitus, DM)是目前临床医学中最普遍的代谢性疾病之一,并且已经成为全球关注的公共卫生问题。沉默信息调节因子2相关酶1(silencing information regulator 2 related enzyme 1, SIRT1)是一种腺嘌呤二核苷酸依赖性去乙酰化酶,参与糖代谢和胰岛素的分泌过程,在DM的发病机制中扮演了重要角色。糖尿病主要是由于胰岛素分泌缺乏或者胰岛素抵抗导致的代谢紊乱综合征。SIRT1不仅在β细胞中通过p53、叉头盒转录因子O(forkhead box transcription factor class O, FoxO)、烟酰胺磷酸核糖转移酶(nicotinamide phosphoribose transferase, NAMPT)等相关靶点影响胰岛素分泌;还可以通过胰岛素受体、脂联素影响胰岛素敏感性从而干扰胰岛素抵抗。此外,SIRT1还可以通过抑制NF-κB信号通路,保护胰岛β细胞免受氧化应激和炎症细胞因子的刺激。同时,SIRT1通过促进线粒体的生物发生保证机体内所有细胞活动的供能,并避免脂质的积累。白色脂肪组织(white adipose tissue,WAT)、糖异生功能异常导致的糖尿病也受到SIRT1诸多影响。本文旨在探讨SIRT1与DM的关系及其中涉及的相关信号网络。

大肿瘤抑制激酶(Large tumor suppressor kinase,LATS)是Hippo信号通路的核心成员,由于其结构的特殊性,在人体内可以通过对细胞周期、细胞骨架动力学和细胞迁移等方面的调控达到抑癌等作用。已经有研究表明,LATS会影响消化道肿瘤的发生发展。本文就LATS的结构、作用以及与消化道肿瘤的相关性等做一综述,深入了解LATS在消化道肿瘤发生发展过程中所起到的作用。

Objective: To investigate the protective effect of Dracocephalum moldavica L. on stroke based on network pharmacology. Methods: The effective components of Dracocephalum moldavica L. were searched by NCBI and CNKI. The effective targets of Dracocephalum moldavica L. were predicted by Pubchem and swiss target prediction databases. The target genes related to cerebral stroke were searched by GeneCards and Omim databases. The Venn diagram was constructed to screen the intersection genes. Cytoscape was used to establish and visualize the network diagram of drugs, components, targets and diseases. String software was used to construct the protein network interaction diagram. GO enrichment and KEGG analysis were performed using the DAVID database. Results: A total of 23 effective components of Dracocephalum moldavica L. were found by searching the literature, and there were 1682 corresponding targets. The main molecules were NADPH oxidase 4 (NOX4), xanthine dehydrogenase (XDH), myeloperoxidase (MPO), etc. Through PPI topology analysis, 57 core targets were obtained; GO enrichment analysis showed that 443 biological processes (BP), 104 molecular functions (MF) and 66 cellular components (CC) were involved. The results of KEGG showed that 143 signaling pathways were involved, including cancer pathway (hsa05200: pathways in cancer), PI3K-Akt signaling pathway (hsa04151: PI3K-Aktsignaling pathway), neuroactive ligand-receptor interaction (hsa05022: neuroactive ligand-receptor interaction) and so on. Conclusion: This study preliminarily revealed that Dracocephalum moldavica L. can treat stroke through a variety of targets and pathways, providing a theoretical basis for further scientific experiments.

Microplastics are environmental pollutants that have attracted worldwide attention. In this paper, the toxic effects and mechanism of microplastics were reviewed, and the future research direction was pointed out. Microplastics can penetrate cell membrane directly into cells or tissues and organs, causing damage to digestive system and reproductive system. Nanoscale microplastics can even enter the nucleus, cause DNA damage, induce autophagy and apoptosis of cells, and produce oxidative damage. Current studies on the toxic effects of microplastics mainly use materials prepared in the laboratory. Further studies should be conducted on microplastics in the aging state and natural environment in order to fully understand the possible damage to organisms caused by microplastics.

Rheumatoid arthritis is a chronic systemic autoimmune disease. The inflammatory response caused by the abnormal activation of the immune system will lead to the formation of pannus in the synovium of the joints, and the gradual destruction of bone and cartilage. The clinical manifestations are pain and swelling of multiple joints, or even deformity, affect the quality of life of patients, and eventually lead to loss of joint function. The main reason for its onset and recurrence is that the immune system produces immune cells, cytokines and antibodies against self-antigens, among which the NLRP3 inflammasome plays a key role in the inflammatory response. As a binding protein of NLRP3, NEK7 kinase acts downstream of K⁺ efflux and regulates the oligomerization and activation of NLRP3 inflammasomes. However, there have been no report on the involvement of NEK7 in the inflammatory activities of rheumatoid arthritis through the activation of NLRP3 inflammasomes. This article reviews the research progress of NLRP3 inflammasome activation and NEK7 kinase regulating the process of NLRP3 inflammasome activation, in order to provide new insights for the understanding of NLRP3 inflammasome activation by NEK7 on inflammatory activity in rheumatoid arthritis and future research related to targeted therapy.

目的:评估通过ASPECT评分筛选发病6～24 h急性颅内大血管闭塞的缺血性卒中行血管内治疗的安全性及有效性。方法:本研究回顾性分析2012年1月至2020年10月之间于包头市中心医院神经内科临床诊断为发病24 h内急性颅内大血管闭塞的缺血性卒中并行血管内治疗的患者,详细登记患者基线及血管内治疗相关信息,比较发病6～24 h患者与发病6 h内患者血管内治疗的血管开通、预后以及手术安全性的情况。血管开通成功定义为mTICI分级2b-3级,功能独立的结局定义为mRS评分0-2分,手术安全性指标为术后24 h症状性颅内出血比率,将数据进行相关统计学分析。结果:共有369例患者入组。全部入组患者按发病6 h组及发病6～24 h组经单因素分析均没有差别;在校正了所有单因素分析:90 d功能独立（OR=0.840,95%CI:0.557～1.267;P=0.405）及良好预后（OR=0.968,95%CI:0.623～1.505;P=0.887）仍没有差别,在校正了单因素年龄、性别、NIHSS评分、ASPECT评分后比较两组之间的90 d功能独立（OR=0.696,95%CI:0.439～1.104;P=0.124）及良好预后（OR=0.750,95%CI:0.453～1.241;P=0.264）依然没有差别,在校正了单因素年龄、性别、NIHSS评分,、ASPECT评分、高脂血症、心房颤动、冠心病、进展性卒中、病变部位、存在ICAS、补救支架置入、球囊扩张后比较两组之间90 d功能独立（OR=0.579,95%CI:0.300～1.116;P=0.103）及良好预后（OR=0.965,95%CI:0.482～1.932;P=0.920）没有差别。结论:ASPECT评分用于筛选发病6～24 h的急性颅内大血管闭塞的缺血性脑卒中患者行血管内治疗同样有效,为患者提供及时、安全、可行的治疗。

Objective: To investigate the effect and mechanism of puerarin (Pue) in the treatment of postmenopausal osteoporosis (PMOP) in rats. Methods: Female SD rats were divided into sham operation group (SHAM group), model group (PMOP group), low-dose puerarin group (Pue-L group) and high-dose puerarin group (Pue-H group). In the SHAM group, partial fat around the ovary was removed, and bilateral ovaries were removed in the other groups. Bone mineral density (BMD) and hematoxylin-eosin (HE) staining were used to observe the femoral tissue at 4 weeks after operation to determine whether the model was successful. After successful modeling, rats in Pue-L group and Pue-H group were subcutaneously injected with different concentrations of puerarin injection, and rats in SHAM group and PMOP group were injected with the same amount of normal saline. BMD of rats was detected after 8 weeks of administration. The bone structure was observed by micro-CT scanning and the related parameters were calculated. HE staining was used to observe the pathological changes of rat femur. The protein expression level of JAK2/STAT3 signaling pathway was detected by Western Blot (WB). Results: (1) Pue significantly increased BMD in PMOP rats. (2) Micro-CT analysis showed that Pue could improve the bone microstructure of PMOP rats. (3) HE staining showed that after Pue treatment, the bone loss of PMOP rats decreased, the number and density of trabecular bone increased, and the pathological changes were restored. (4) WB results showed that compared with SHAM group, the expression levels of p-JAK2 and p-STAT3 protein in PMOP group were increased (P＜0.001). Compared with PMOP group, the expression levels of p-JAK2 and p-STAT3 protein in Pue-L group and Pue-H group were decreased (P＜0.001). Conclusion: Puerarin can effectively treat osteoporosis in PMOP rats, which may play an anti-osteoporosis role by inhibiting the activation of JAK2/STAT3 pathway.

Objective: To investigate the current status of medication compliance of elderly inpatients with chronic diseases and analyze its influencing factors, with the purpose of providing references for improving medication compliance of elderly patients with chronic diseases. Methods: :General information questionnaire, medication adherence report scale (MARS) and the eHealth literacy scale (eHEALS) were designed to investigate 500 inpatients who were randomly selected from an AAA hospital. Univariate analysis, Pearson correlation analysis and multivariate logistic regression analysis were used to analyze the influencing factors of medication compliance in elderly hospitalized patients with chronic diseases. Results: :Among 500 elderly inpatients with chronic diseases, 213 (42.6%) had good medication compliance, 287 (57.4%) had poor medication compliance. Pearson correlation analysis results showed that the total score of medication compliance of elderly inpatients with chronic diseases was positively correlated with the total score of eHEALS (r=0.319, P=0.008). Multivariate logistic regression analysis results showed that education level, residence, economic level, age, current working status and e-health literacy were the main influencing factors of medication compliance of elderly hospitalized patients with chronic diseases (P＜0.05). Conclusion: :The level of medication compliance in elderly hospitalized patients with chronic diseases is generally low. Health publicity and education on patients with chronic diseases should be strengthened to improve their cognition degree of chronic disease hazards, chronic disease prevention and treatment ability and medication compliance, so as to reduce the risk of chronic disease complications and lower their burden.

目的:研究高蛋白膳食模式对超重/肥胖成人肾功能、体重、血脂的影响,为后续研究高蛋白膳食对超重和肥胖的干预提供参考依据。方法:招募140名20～45岁超重/肥胖者,利用简单随机化法分为高蛋白膳食组(HP组:蛋白质供能比30%)和标准蛋白膳食(SP组:蛋白质供能比15%),干预60 d,观察两组体重、体脂肪、肾功能(肌酐、尿素氮、尿酸)及血脂(低密度脂蛋白、总胆固醇、三酰甘油)变化。结果:受试者140例,男性41例,女性99例,其中HP组70例,SP组70例。第一周,HP组能量和SP组比较差异无统计学意义(P>0.05);HP组蛋白质、碳水化合物、脂肪供能比与SP组比较差异有统计学意义(P<0.001);第五周,HP组能量与SP组比较差异无统计学意义(P>0.05);HP组蛋白质、碳水化合物、脂肪供能比与SP组比较差异有统计学意义(P<0.001)。干预前,HP组体重、体脂肪与SP组比较差异无统计学意义(P>0.05),干预后,两组指标均较干预前有所改变,差异有统计学意义(P<0.05),且HP组与SP组体重下降率比较差异有统计学意义(P<0.001);HP组与SP组体脂肪下降率比较差异有统计学意义(P<0.001),且HP组体重、体脂肪下降更明显。血脂变化情况:干预前,HP组甘油三酯、低密度脂蛋白、总胆固醇与SP组比较差异无统计学意义(P>0.05);干预后,两组指标均较干预前有所改变,差异有统计学意义(P<0.05),且HP组甘油三酯、低密度脂蛋白、总胆固醇下降率与SP组比较差异均有统计学意义(P<0.001),且HP组下降比SP组明显。肾功能变化:干预前,HP组肌酐、尿素氮、尿酸与SP组比较差异无统计学意义(P>0.05),干预后,与基线值相比,两组肌酐均有所下降,差异有统计学意义(P<0.05),SP组尿酸有所降低,差异有统计学意义(P<0.05),尿素氮差异无统计学意义(P>0.05),HP组尿酸差异无统计学意义(P>0.05),尿素氮有所降低,差异有统计学意义(P<0.05)。两组间比较显示HP组尿素氮、尿酸下降率与SP组比较差异有统计学意义(P<0.05),且HP组尿素氮下降更明显,SP组尿酸下降更明显,而两组间肌酐下降率差异无统计学意义(P>0.05)。结论:短期高蛋白膳食和标准蛋白膳食均能降低超重/肥胖者体重、体脂肪,改善血脂、肌酐和尿素氮水平;高蛋白饮食降低体重、体脂肪及改善血脂、尿素氮作用优于标准蛋白膳食;高蛋白饮食降低尿酸水平作用不及标准蛋白膳食;短期高蛋白饮食在减重过程中对肾功能无损害。

由于牙齿实际效果和设计移动间存在一定的差异，无托槽隐形矫治技术大部分病例第一序列结束时需要进行精细化调整甚至中期重启。因此，了解隐形矫治技术牙齿移动效率及其影响因素非常重要。本文就无托槽隐形矫治效率影响因素如设计因素(附件、支抗、过矫正、牙齿移动步骤、矫治器步幅、牙齿移动量、初始牙齿角度、矫治器更换频率)、患者年龄及牙周条件、矫治器材料和药物等物理因素等作一综述，为临床选择合适适应证及设计方案提供指导。

Objective: to establish the model of distal middle cerebral artery occlusion (Distal middle cerebral artery occlusion,dMCAO) in C57BL/6 mice by electrocoagulation and to improve the mouse model of acute ischemic stroke (Stroke). Methods: 54 male C57BL/6 mice aged 8-10 weeks were randomly divided into normal group (n=6), sham operation group (n=6) and dMCAO model group (n=42).The model was established by double electrocoagulation of one side of the cortical branch of the middle cerebral artery and ligation of the ipsilateral common carotid artery.The survival rate of 3 days and 7 days and the success rate of 7 days were evaluated; the proportion of cerebral infarction volume was evaluated by TTC staining on 7 days; the cerebral blood flow was evaluated by laser microcirculation blood flow imaging; and the motor coordination ability of mice was evaluated by rotating stick test on 3 days and 7 days. Results: the 3-day and 7-day survival rate of normal group and sham operation group was 100 %.The average survival rate of 3-day and 7-day model group was 83.35 %, 78.43 % and 66.7 %, respectively.The infarct volume of model mice was evaluated by TTC staining.The proportion of infarct volume in normal group and sham operation group was 0 %.The proportion of infarct volume in MCAO model group was (18.22 ±0.89) %, and the confidence interval of 95 % was (17.28,19.15) %.The cerebral blood flow of model mice was evaluated by laser microcirculation blood flow imager.there was no significant difference in the proportion of bilateral cerebral blood flow between the normal group and the sham operation group.In the dMCAO model group, the infarcted cerebral blood flow decreased by (53.85 ±1.22) % and 95 % confidence interval (52.57,55.13) % compared with the contralateral cerebral blood flow in the dMCAO model group (n=6).The motor ability of the model mice was evaluated by the stick time in the stick test, there was no significant difference between the normal group and the sham operation group, but there was significant difference between the dMCAO model group (n=6) and the sham operation group. Conclusion: the reliable dMCAO model of C57BL/6 mice can be established by double electrocoagulation of unilateral middle cerebral artery and ligation of ipsilateral common carotid artery.

Objective: To explore the current status and relationship of electronic health literacy , health promotion behavior , and quality of life in elderly patients with chronic diseases. Methods: From August 1,2022 to February 20,2023, 325 chronic disease patients ≥60 years old were randomly selected using convenience sampling method. A structural equation model was constructed to analyze the relationship between electronic health literacy, health promotion behavior and health related quality of life in elderly patients with chronic diseases. Results: The total score of eHEALTH for patients was (18.73±10.64), the total score of health promotion behavior was (124.02±19.63), the total utility value of the European Five Dimensional Health Scale(EQ-5D-5L) was (0.79±0.22), and the EQ-VAS score was (72.35±16.21).The total score of patients' electronic health literacy is positively correlated with the total score of health promotion behavior (r=0.197, P＜0.001); The total score of electronic health literacy is positively correlated with the score of quality of life (r=0.188, P＜0.001), and the total score of health promotion behavior was also positively correlated with EQ-VAS scores (r=0.289, P＜0.001). Structural equation model analysis showed that electronic health literacy in elderly patients with chronic diseases can directly affect their quality of life, with a direct effect of 0.168 (P＜0.05); Electronic health literacy can also indirectly affect patients' quality of life by influencing their health promoting behavior, with an indirect effect of 0.046 (P＜0.05). Conclusion: Medical institutions should attach importance to the level of electronic health literacy of patients, implement targeted health intervention measures, effectively improve the level of electronic health literacy, and thereby enhance their health promotion behavior and quality of life.

低氧预适应是通过亚致死的低氧处理后,激活体内小分子内源性保护机制,让机体对接下来的更严重或致死性低氧刺激产生耐受/抗性。神经细胞是一种能接收和传导兴奋的细胞,对氧含量的变化十分敏感,其能量代谢随氧气变化较为显著。在低氧环境下,神经细胞的腺嘌呤核苷三磷酸(adenosinetriphosphate,ATP)合成减少可激活AMP激活的蛋白激酶[adenosine5’-monophosphate(AMP)-activated protein kinase,AMPK]和TSC1/TSC2复合体抑制哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)。mTOR的一个复合物mTOR复合体1(mTORC1)的表达对机体的能量代谢产生影响。低氧预适应,通过激活或抑制一些基因表达让神经细胞有效利用氧气,使机体产生低氧耐受。在氧浓度低的生存环境下,通过低氧预适应调节能量变化增加机体存活的可能性。高原、航空航天事业、水下作业以及病理性的低氧时,低氧预适应诱导相关分子变化可防止对氧有大量需求的脑组织发生病变,增加神经细胞的存活时间,减少死亡。

Objective: To explore whether down-regulation of neutrophils can alleviate the disease severity of collagen-induced arthritis (CIA) mice, and to analyze the differences in transcriptome expression after the formation of neutrophil extratrapping networks (NETs), providing a theoretical basis for the follow-up research on the effect of NETs on RA disease progression. Methods: DBA1 mice were used to construct a CIA model, and anti-Ly6G monoclonal antibody was used to knock down neutrophils in CIA mice after secondary collagen boosting immunization (once a week), and the intervention was continued for 8 weeks. After 8 weeks, the mice were sacrificed to collect the lungs, spleens, and hindlimbs of mice for histopathological observation; RA peripheral blood neutrophils were collected by magnetic bead sorting, and neutrophil nuclei were stained with DAPI dye, and kept at room temperature. After standing under light for 15 min, the morphological characteristics of neutrophils were observed under microscope; RA peripheral blood neutrophils were collected, stimulated with different concentrations (8 nmol/L, 16 nmol/L, 32 nmol/L) of PMA, cultured for 2 h, and stained with NETs markers. The optimal concentration of stimulating neutrophils to form NETs was observed under a fluorescent inverted microscope; Samples were collected for transcriptome sequencing after stimulation of neutrophils using PMA to analyze changes in transcriptome expression after formation of RA NETs. Results: Down-regulation of neutrophil expression partially alleviated the pathological changes in the joint synovium, lung and spleen of CIA mice; 8 nmol/L PMA stimulated RA neutrophils for 2 h, 37°C, 5 % CO₂ culture; Differential analysis screened out 2742 differential genes(P≤0.05),including 1579 up-regulated differential genes [log₂(RA_control/RA_PMA＞0)] and 1163 down-regulated differential genes [log₂(RA_control/RA_PMA＜0]. 340 significantly different genes (log₂|RA_control/RA_PMA|≥2) were identified and displayed by PPI network construction; GO, KEGG and GSEA KEGG pathway analysis of 340 differential genes were enriched respectively as follows: immune response and signal receptor activity In the regulation of cytokines, the mutual regulation pathway between cytokines, the interaction of cytokine receptors, apoptosis and Toll-like receptor signaling pathways. Conclusion: Down-regulation of neutrophils can alleviate the pathological changes of joint synovium, lung and spleen in CIA mice; the formation of NETs in RA is related to immune regulation, apoptosis and the interaction between cytokines, indicating that the formation of NETs may be involved in the above The immune process plays an important role in the progression of RA disease.

Objective: To detect the change of breath alcohol level over time in 20 to 22 years old youth by establishing a methodology, and to to reflect blood alcohol concentration, and to compare the sex differences in alcohol metabolism. Methods: The change of end-tidal alcohol concentration over time was detected with police breathalyzer, and the software DAS 3.0 was used to analyze the metabolic kinetics, and the sex differences of alcohol metabolism after drinking among youths aged 20 to 22 years. Results: The coefficient of variation detected by this method was less than 5 %. After drinking 100ml Chinese spirit (52 % alcohol by volume), the area under the curve AUC(0-t) in females was larger than that in males, the MRT(0-t) in vivo of females was significantly longer than that of males, and the clearance rate CLz in females was smaller than that in males. Conclusion: The method is simple, non-invasive, feasible and reproducible. Young males aged 20 to 22 metabolize faster than females of the same age after intaking same amount of liquor. On average, it takes about 3.5 hours for females aged 20 to 22 completely removing alcohol from the body, while it only takes about 2 hours for males in the same age group. Metabolic kinetics of alcohol in this age group was established in this study.

正>菟丝子为旋花科植物菟丝子的干燥成熟果实,具有补肾益精,安胎明目等功效[1],且具平补阴阳之性,临床多用于治疗不孕、卵巢早衰、反复流产等女性疾病。因上述疾病的发生多与雌性生殖系统功能障碍有关,近年来,国内围绕其对雌性生殖系统功能障碍进行了相关实验研究,取得一定进展。笔者检索国内近20年来菟丝子对雌性生殖系统功能的文献作一综述,希望能为临床或基础研究提供参考。1 菟丝子对生殖内分泌系统的影响既往基于中医学"肾主生殖"的理论,