25 June 2024, Volume 40 Issue 6
    

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  • WU Peng, YANG Zhanjun
    Journal of Baotou Medical College. 2024, 40(6): 1-6. https://doi.org/10.16833/j.cnki.jbmc.2024.06.001
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    Objective: To investigate the protective effect of Dracocephalum moldavica L. on stroke based on network pharmacology. Methods: The effective components of Dracocephalum moldavica L. were searched by NCBI and CNKI. The effective targets of Dracocephalum moldavica L. were predicted by Pubchem and swiss target prediction databases. The target genes related to cerebral stroke were searched by GeneCards and Omim databases. The Venn diagram was constructed to screen the intersection genes. Cytoscape was used to establish and visualize the network diagram of drugs, components, targets and diseases. String software was used to construct the protein network interaction diagram. GO enrichment and KEGG analysis were performed using the DAVID database. Results: A total of 23 effective components of Dracocephalum moldavica L. were found by searching the literature, and there were 1682 corresponding targets. The main molecules were NADPH oxidase 4 (NOX4), xanthine dehydrogenase (XDH), myeloperoxidase (MPO), etc. Through PPI topology analysis, 57 core targets were obtained; GO enrichment analysis showed that 443 biological processes (BP), 104 molecular functions (MF) and 66 cellular components (CC) were involved. The results of KEGG showed that 143 signaling pathways were involved, including cancer pathway (hsa05200: pathways in cancer), PI3K-Akt signaling pathway (hsa04151: PI3K-Aktsignaling pathway), neuroactive ligand-receptor interaction (hsa05022: neuroactive ligand-receptor interaction) and so on. Conclusion: This study preliminarily revealed that Dracocephalum moldavica L. can treat stroke through a variety of targets and pathways, providing a theoretical basis for further scientific experiments.
  • ZHU Hongbo, DAI Yujing, ZHAO Jie, HUO Dongsheng
    Journal of Baotou Medical College. 2024, 40(6): 7-13. https://doi.org/10.16833/j.cnki.jbmc.2024.06.002
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    Objective: To explore the mechanism of ginsenoside Rb1 in the treatment of Parkinson 's disease by using network pharmacology technology, and to provide scientific theoretical basis for the clinical rational application of ginsenoside Rb1. Methods: The targets of ginsenoside Rb1 were predicted in SwissTargetPrediction, SEA and SuperPred databases. The related targets of Parkinson's disease were obtained in the GeneCards and Omim databases using the keyword 'Parkinson Disease'. The ginsenoside Rb1 and the target of Parkinson's disease were mapped to each other, and the Veen diagram was made to obtain the intersection gene. Then, Cytoscape 3.8.2 software was used to construct the 'drug-target' network ; the 21 common drug targets related to Parkinson's disease in the Venn diagram were imported into the String (https://string-db.org/) database for protein-protein interaction prediction, so as to predict the core targets. The core targets of ginsenoside Rb1 in the treatment of Parkinson's disease were imported into the DAVID database to obtain GO analysis results and KEGG enrichment results. AutoDock Vina was used to perform molecular docking between ginsenoside Rb1 and key targets to verify their interaction activity. Results: There were four core targets of ginsenoside Rb1 in the treatment of Parkinson's disease, namely BCL2L1, VEGFA, FGF2, KDR, with 28 related pathways. Combined with the biological characteristics of ginsenoside Rb1, it was found that ginsenoside Rb1 treatment of Parkinson's disease mght be involved in the biological regulation process through the PI3K/Akt signaling pathway, and this regulation process was closely related to the mechanism of apoptosis in cell bioengineering. Through the molecular docking verification of the key target and ginsenoside Rb1, the target interaction was highly combined. Conclusion: The mechanism of ginsenoside Rb1 in the treatment of PD may play a role by reducing the biological process of apoptosis. The related pathways affected are PI3K/Akt signaling pathway, MAPK signaling pathway, Notch signaling pathway, and BCL2L1, VEGFA, FGF2, KDR and other targets.
  • ZHANG Shibin, WANG Lu, LI Hao, SUN Yihong, SONG Wei, YAN Xusheng, WANG Yanguo, JIA Jianxin
    Journal of Baotou Medical College. 2024, 40(6): 14-19. https://doi.org/10.16833/j.cnki.jbmc.2024.06.003
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    Objective: To explore whether the glycosides of cistanche can improve the learning and cognitive function of sleep deprivation model rats by regulating synaptic plasticity. Methods: Fifty male Wistar rats were randomly divided into blank control group (Control), platform control group (PC), model group (Model), glycosides of cistanche group (GCs) and estazolam group (Est). The sleep deprivation model of rats was prepared by modified multi-platform water environment method. Morris water maze and open field test were used to detect the spatial cognitive function and emotional changes of rats. Nissl staining was used to observe the changes of morphology and quantity of nerve cells in hippocampal CA1 area of rats. Western blot and RT-PCR were used to detect the expression levels of synaptophysin (SYN), postsynaptic membrane dense substance 95 (PSD-95) and brain-derived neurotrophic factor (BDNF). Results: Morris water maze results showed that compared with the Control group, the learning and cognitive ability of rats in the Model group was significantly decreased (P<0.05), and the learning and memory function of rats was improved after GCs treatment (P<0.05). The results of the open field test showed that compared with the Control group, the movement distance and standing times of the Model group were significantly increased (P<0.05), the resting time was significantly shortened(P<0.05), and the anxiety was increased, while after GCs treatment, the movement distance and standing times decreased (P<0.05), the resting time increased (P<0.05), and the anxiety was improved. The results of Western blot and RT-PCR showed that the protein and gene expression levels of BDNF, SYN and PSD-95 in the Model group were significantly decreased (P<0.05), while after treatment with GCs, the expression levels of BDNF, SYN and PSD-95 were significantly up-regulated (P<0.05). Conclusion: Glycosides of cistanche may affect synaptic plasticity by regulating the expression of synaptic related markers, thereby improving the learning and cognitive function of sleep deprivation model rats.
  • SUN Jianfang, ZHANG Xuejun, SU Shanna, HUO Dongsheng
    Journal of Baotou Medical College. 2024, 40(6): 20-24. https://doi.org/10.16833/j.cnki.jbmc.2024.06.004
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    Objective: To explore the protective effect and mechanism of ginsenoside Rb1 (GsRb1) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Methods: C57BL/6 mice were randomly divided into control group, model group, GsRb1 administration group (low, medium and high dose groups). LPS was given intratracheally to establish the model. The administration group was given intraperitoneal injection of different doses of GsRb1 pretreatment 3 days before modeling. After 12 hours of modeling, the alveolar lavage fluid was collected and the lung tissue was taken out. The lung wet/dry ratio was calculated. The levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in lavage fluid and the activity of myeloperoxidase (MPO) in lung were detected by kit. The expression of nuclear factor-κB (NF-κB) protein in lung tissue was detected by Western blot. Results: High dose GsRb1 could significantly reduce the wet/dry ratio of lung tissue (P<0.05). Medium and high doses of GsRb1 could significantly reduce the MPO activity in lung tissue (P<0.05). High dose GsRb1 could significantly reduces the levels of IL-1β and TNF-α in alveolar lavage fluid of mice (P<0.05). High dose GsRb1 could significantly reduce the expression of NF-κB p65 protein in lung tissue (P<0.05). Conclusion: GsRb1 may reduce inflammation response and inhibit LPS-induced ALI in mice by regulating the NF-κB pathway.
  • WANG Haiyan, ZHANG Yonghong
    Journal of Baotou Medical College. 2024, 40(6): 25-29. https://doi.org/10.16833/j.cnki.jbmc.2024.06.005
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    Objective: To investigate the influencing factors and roles of serum Cys C in microangiopathy of type 2 diabetes mellitus.Methods: A total of 830 patients with T2DM admitted from September 2020 to June 2022 were selected as the research objects, and the patients were divided into observation group (type 2 diabetic microangiopathy group) and control group (simple type 2 diabetes group) according to whether they had microangiopathy. The basic data and biochemical indexes of the two groups were compared. Results: The prevalence of hypertension, duration of diabetes and age in the observation group were higher than those in the control group (P<0.05). The levels of glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), serum creatinine (Scr), uric acid (UA), serum cystatin C (Cys C), low density lipoprotein (LDL), triglyceride (TG), serum total cholesterol (TC), apolipoprotein A (APOA) and apolipoprotein B (APOB) in the observation group were higher than those in the control group, and the level of high density lipoprotein (HDL) was lower than that in the control group (P<0.05). Binary logistic regression analysis showed that hypertension, course of disease, HbA1c, FPG, Cys C, HDL and APOA were the influencing factors of T2DM microangiopathy. The receiver operating curve (ROC) results showed that Cys C could be used as a potential diagnostic indicator for T2DM microvascular disease (AUC=0.707, P=0.000). Conclusion: HbA1c, FPG, HDL, APOA, hypertension, duration of diabetes, Cys C and other factors are independent influencing factors of T2DM microangiopathy, and serum Cys C can be used as a potential diagnostic indicator. The focus of T2DM microangiopathy management is not only to control blood glucose, but also to find prevention and treatment targets from a new perspective, providing new ideas for the prevention and treatment of T2DM microangiopathy.
  • WANG Hongbin, HAO Xijun, YANG Fang, CHEN Changxiang, LUO Meijie
    Journal of Baotou Medical College. 2024, 40(6): 30-36. https://doi.org/10.16833/j.cnki.jbmc.2024.06.006
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    Objective: To analyze the risk factors of upper limb dysfunction in breast cancer surgery patients,to construct the risk model of the risk factors affecting upper limb dysfunction and to verify its performance.Methods: From February 2021 to February 2022, 350 women who had passed 2 to 5 months after modified radical breast cancer surgery were selected for an unmatched case-control study. After assessment by Rowes rating System for Bankart repair, those with a score of <75 points were as the case group and those with a score of ≥75 points were as the control group. Logistic statistical analysis was used to analyze the risk factors of upper limb dysfunction in breast cancer surgery patients, to construct the nomogram risk prediction model and to verify it internally. Results: University degree or above, satisfactory marital relationship and high level of self-efficacy were protective factors for upper limb dysfunction in breast cancer surgery patients (P<0.05). Aged 65 to 80 years, wound pain, insomnia, rarely active upper limb exercise, very fear of exercise, recurrence of breast cancer, no desire for recreational activities, and not being close to friends were the risk factors for upper limb dysfunction of breast cancer surgery patients (P<0.05). The above factors were included and the nomogram risk prediction model was built. The results showed that intervention factors such as wound pain, marital relationship, insomnia and active upper limb movement had a great impact on the risks of upper limb dysfunction in breast cancer surgery patients. Internal verification results showed that the area under the ROC curve of the model was 0.858. The calibration curve showed a good consistency between the risks of breast cancer upper limb dysfunction predicted by the nomogram and the actual risks, and the C index was 0.837 after correction. Conclusion: The constructed risk model of risk factors for upper limb dysfunction in patients with breast cancer surgery has a good prediction effect. It can assist clinical medical and nursing staff to screen high risk factors affecting upper limb dysfunction, especially pain symptoms, insomnia symptoms, active movement behavior, marital relationship and other factors that can be intervened. This allows for early response measures and postoperative rehabilitation.
  • LIU Hai, HUANG Guanhua
    Journal of Baotou Medical College. 2024, 40(6): 37-42. https://doi.org/10.16833/j.cnki.jbmc.2024.06.007
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    Objective: To analyze the relationship between primary headache and the risk of primary hypertension, and to provide evidence for the prevention and treatment of primary hypertension and primary headache. Methods: The research subjects were selected from young people, ranging in age from 16 to 24 years old, with an average age of 18.6 years old. Through the physical examination data, the propensity score matching method was used to balance the confounding factors, and the logistic regression analysis was used to explore the relationship between primary headache and the risk of primary hypertension before and after matching. Results: There were differences between the hypertension group and the normal blood pressure group in nationality (P=0.007), BMI (P=0.005), family history of hypertension (P=0.017), salt consumption (P=0.004), meat type (P=0.015), diet matching (P=0.015), sleep quality (P=0.018), weekly physical activity (P<0.001), sedentary time (P=0.023), headache type (P<0.001), etc. A total of 246 matching data were obtained after matching with 1∶1 tendency score, and the confounding factors between the two groups reached a balance. Logistic regression analysis showed that the risk of hypertension in the migraine group before matching was 4.474 times higher than that in the non-headache group, and the risk of hypertension in the tension-type headache group was 1.942 times higher than that in the non-headache group. After matching, the risk of hypertension in the migraine group was 2.532 times higher than that in the non-headache group. The tension-type headache group and other headache groups were not related to hypertension. Conclusion: Migraine in primary headache have an impact on the risk of primary hypertension, and it is independent risk factors for primary hypertension.
  • ZHANG Haiyan, YUAN Rui, ZHOU Wenhui, LIU Dan, ZHANG Guangwei
    Journal of Baotou Medical College. 2024, 40(6): 43-48. https://doi.org/10.16833/j.cnki.jbmc.2024.06.008
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    Objective: To detect the expression level of circular RNA-BBS9 in acute cerebral infarction (ACI), and to explore its possibility as a potential biomarker for early diagnosis of ACI. Methods: A total of 34 patients with ACI admitted from January to December 2021 were randomly selected as the case group, and 41 patients without ACI were selected as the control group. The general data and blood samples were collected for bioinformatics analysis. Circ RNA with the greatest difference was selected as the target gene, and the correlation between the general data, the expression level of the target gene and the occurrence of ACI in the two groups was analyzed. ROC curve was used to analyze the value of target gene in the diagnosis of ACI. Results: The proportion of male, age, history of hypertension, history of coronary heart disease, history of smoking, history of drinking and blood pressure in the case group were higher than those in the control group (P<0.05). The CircRNA with the greatest difference was Circ-BBS9. The expression level of Circ-BBS9 in the case group was lower than that in the control group (P<0.05). Sex, age, history of hypertension, history of coronary heart disease, history of smoking, history of drinking, blood pressure and Circ-BBS9 expression were all related to the occurrence of ACI (P<0.05). The expression of Circ-BBS9 was negatively correlated with the occurrence of ACI, while other factors were positively correlated with the occurrence of ACI (P<0.05). Circ-BBS9 had the value of diagnosing ACI. Conclusion: Circ-BBS9 is a protective factor of acute cerebral infarction, and the expression level of Circ-BBS9 is an independent factor affecting the occurrence of ACI. Detection of Circ-BBS9 in peripheral blood has potential value in predicting the pathogenesis of ACI.
  • LI Rong, LIU Feifei
    Journal of Baotou Medical College. 2024, 40(6): 49-55. https://doi.org/10.16833/j.cnki.jbmc.2024.06.009
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    Objective: To evaluate the effects of different doses of sufentanil on postoperative cognitive impairment in aged rats with perioperative cognitive dysfunction. Methods: Sixty aged (18-22 months) rats were randomly divided into 6 groups using a random number table method: control group, PND model group (splenectomy), sufentanil group A (splenectomy+sufentanil 1 μg·kg-1), sufentanil group B (splenectomy+sufentanil 2 μg·kg-1), sufentanil group C (splenectomy+sufentanil 4 μg·kg-1), sufentanil group D (splenectomy+sufentanil 8 μg·kg-1), with 10 rats in each group. First, the Morris water maze was used to conduct space acquisition experiments for 5 consecutive days of all the groups. On the 6th day, model construction and/or preoperative sufentanil intraperitoneal intervention were performed on all the other groups of aged rats except for the control group. All aged rats were tested for spatial memory on the 1, 3 and 7 days after surgery. Results: Space-acquired experiments made the memory of platform position in aged rats gradually deepen with time (P<0.05), and rats gained effective memory of platform position, there was no difference between the groups. The reference memory test results showed that the difference in spatial memory between the control group and each of the other groups was statistically significant (P<0.05). There was significant difference in spatial memory ability between the model group and the sufentanil B group, the sufentanil C group and the sufentanil D group (P<0.05). In addition to the control group, the spatial memory ability of the sufentanil C group was significantly different from that of the other groups (P<0.05). Conclusion: Different doses of sufentanil have different effects on postoperative spatial memory in elderly rats, while intraperitoneal injection of 4 μg·kg-1 sufentanil can significantly improve the spatial memory ability and postoperative cognitive function of splenectomy PND model rats.
  • MENG Zhiyi, MENG Xianmei, LIU Feifei, ZHANG Jingjie, NIAN Yuanyuan, WANG Chi
    Journal of Baotou Medical College. 2024, 40(6): 56-60. https://doi.org/10.16833/j.cnki.jbmc.2024.06.010
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    Objective: To investigate the efficacy and safety of the integrated traditional Chinese and Western medicine therapy with Biling Weitong Granules in combination with conventional Western medicine quadruple or triple therapy compared to traditional Western medicine therapy for eradicating Helicobacter pylori (H.pylori). Methods: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database and Sinomed were searched, and the randomized controlled studies about the application of Biling Weitong Granule for eradicating H.pylori eradication were collected. The retrieval period was from the establishment of the database to November 2022. Data extraction and literature quality evaluation were performed on the retrieved literature according to the Cochrane system evaluation method. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 4 articles and 506 patients were included. The results of Meta-analysis showed that the eradication rate of H.pylori in the experimental group was higher than that in the control group (OR=4.18, 95%CI: 2.57-6.79, I2=0%, P<0.00001). In terms of safety, the incidence of adverse reactions in the experimental group was lower than that in the control group (OR=0.30, 95%CI: 0.10-0.85, I2=0%, P=0.02). Conclusion: The integrated traditional and Western medicine treatment regimen with Biling Weitong Granules is significantly better than the western medicine quadruple and triple therapy in terms of efficacy and safety.
  • LIU Qirong, WU Yuqiang, YUE Guihua, DENG Xiaoling, LUO Yuan
    Journal of Baotou Medical College. 2024, 40(6): 61-65. https://doi.org/10.16833/j.cnki.jbmc.2024.06.011
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    Objective: To explore the correlation between ALEX1 level and clinical features of breast cancer histopathologic detection by immunohistochemistry. Methods: ALEX1 positive rate, protein and mRNA levels were detected by immunohistochemistry, western blotting and PCR in 77 cases of breast cancer and 2 cm adjacent specimens, and the correlation between ALEX1 and clinicopathologic features was analyzed. Results: ALEX1 showed yellow and yellowish brown expression in the cell membrane of 77 breast cancer tissues and adjacent tissues. ALEX1 positive expression in 45 breast cancer tissues was 58.44%, and positive rate in 61 adjacent tissues was 79.22%. There was significant difference between groups (χ2=4.199, P<0.05). The protein expression of ALEX1 in 77 breast cancer tissues and adjacent tissues was 2.05±0.55 and 4.11±0.69, respectively. The protein content of ALEX1 in breast cancer tissues was lower than that in adjacent tissues, and there was significant difference between groups (t=20.85, P<0.001). The expression of ALEX1mRNA was 1.00±0.00 and 0.45±0.08 in 77 paracancer tissues and breast tissues, and there were significant differences in the expression of ALEX1mRNA in different tissues (t=60.330,P<0.001). ALEX1 expression was correlated with pathological type, pathological grade and lymph node metastasis (P<0.05), but not with other indicators (P>0.05). The relationship between ALEX1 level and clinicopathology was observed according to the 3 classification boundaries. The decreased level of ALEX1 was correlated with invasive ductal carcinoma and pathological grade Ⅱ to Ⅲ of breast cancer patients (P<0.05). The AUC area of ALEX1 in breast cancer was 0.646, and the specificity and sensitivity were 55.42% and 65.02%, respectively, indicating the significance of ALEX1 expression detection in the pathological diagnosis of breast cancer. Conclusion: The expression level of ALEX1 in paracancer tissues is significantly higher than that in breast cancer tissues, and the decreased expression of ALEX1 is associated with increased lymph node metastasis and pathological grade of breast cancer.
  • SUO Lingyu, WANG Hailong, WANG Zhepeng, ZHENG Liansheng, ZHANG Qian, DUAN Shuquan
    Journal of Baotou Medical College. 2024, 40(6): 66-68. https://doi.org/10.16833/j.cnki.jbmc.2024.06.012
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    Objective: To detect the expression of coagulation function and tumor markers in patients with colon cancer, and to analyze its relationship with tumor development. Methods: A total of 50 patients with colon cancer diagnosed in the Digestive Minimally Invasive Center of the Second Affiliated Hospital of Baotou Medical College from January 2021 to June 2022 were selected as the observation group, and 50 serum samples with normal results were selected as the control group. The serum tumor markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen-199 (CA-199) and coagulation function related indicators such as prothrombin time (PT) and activated partial prothrombin time (APTT) were detected in the two groups, and the differences in the expression of different indicators between groups and within groups were analyzed. Results: Compared with control group, APTT and PT in observation group were significantly decreased (P<0.05), CEA and CA-199 were significantly increased (P<0.05). In the observation group, compared with different clinical stages (Ⅰ-Ⅱ and Ⅲ-Ⅳ), the time of PT and APTT in Ⅰ-Ⅱ was longer than that in Ⅲ-Ⅳ (P<0.05), and the values of CEA and CA-199 were lower (P<0.05); compared with different differentiation degrees (high-middle differentiation and low differentiation), the time of PT and APTT in high-middle differentiation was longer than that in low differentiation (P<0.05), and the values of CEA and CA-199 were decreased (P<0.05). Conclusion: In patients with colon cancer, tumor markers CEA and CA-199 and coagulation-related indicators APTT and PT are abnormally expressed, and combined detection can provide a basis for clinical diagnosis. At the same time, combined detection can predict the stage and differentiation of colon tumors.
  • WANG Qiaoqiao, LI Ruili
    Journal of Baotou Medical College. 2024, 40(6): 69-73. https://doi.org/10.16833/j.cnki.jbmc.2024.06.013
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    Objective: To analyze the etiological surveillance results of hand-foot-mouth disease in Ulanqab City from 2020 to 2022, and to provide basis for scientific prevention of hand-foot-mouth disease in Ulanqab city. Methods: The samples of hand-foot-mouth cases collected by the Centers for Disease Control and Prevention of each county in Ulanqab City were collected. Real-time fluorescence quantitative PCR (RT-PCR) was used to detect the nucleic acid of enterovirus universal (EV), enterovirus 71 (EV71) and coxsackie virus A16 (CoxA16). Results: From 2020 to 2022, Ulanqab Center for Disease Control and Prevention received a total of 2058 throat swab samples of hand-foot-mouth disease cases, and 90 were generally positive for enterovirus, the positive rate was 4.37%, of which 41 were positive for Cox A16, with a positive rate of 1.99%, and 49 were positive for other types, with a positive rate of 2.38%. The positive rate of nucleic acid detection for hand-foot-mouth disease in different years and different regions was statistically significant (χ2=85.836, χ2=222.672,P<0.05). Conclusion: From 2020 to 2022, hand-foot-mouth disease show a seasonal distribution in Ulanqab city; the positive rates of hand-foot-mouth disease are different in different regions and different age groups. Different years of hand-foot-mouth disease are dominated by other types of pathogens, suggesting that the region should pay attention to the detection of other enterovirus types, grasp the epidemic etiology and variation, and provide a basis for scientific prevention and control of hand-foot-mouth disease.
  • Yang Mei, WU Luofeng, LIU Shan
    Journal of Baotou Medical College. 2024, 40(6): 74-79. https://doi.org/10.16833/j.cnki.jbmc.2024.06.014
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    Objective: To explore the mediating effect of attitudes toward aging on social isolation and self-perception aging of the elderly in rural communities. Methods: The convenience sampling method was used to investigate 422 elderly people in rural communities in Chengdu from June 2021 to May 2022 by using general data questionnaire, Aging Attitude Questionnaire(AAQ), Lubben Social Network Scale (LSNS-6) and the Brief Ageing Perceptions Questionnaire(B-APQ). Results: The B-APQ score of the elderly in the rural community was (51.80±5.21) scores, the LSNS-6 score was (16.59±3.05) scores, and the AAQ score was (78.24±6.03) scores. Self-perceived aging was positively correlated with social isolation (r=0.535, P<0.01) and negatively correlated with attitudes toward aging (r=-0.526, P<0.01); attitudes toward aging played a part of the mediating role between social isolation and self-perceived aging among the elderly in rural communities, and the amount of mediating effect was 0.39 [95%CI(0.245~0.432)], accounting for 52.0% of the total effect. Conclusion: Attitudes toward aging plays a part of the mediating role in the social isolation and self-perception aging relationship of the elderly in rural communities, and the community should help the elderly to establish a positive psychological state and reduce the negative impact caused by social isolation, so as to help the elderly in rural communities get more positive self-perception aging and promote healthy aging.
  • LI Jishuai, ZHANG Rongxin
    Journal of Baotou Medical College. 2024, 40(6): 80-85. https://doi.org/10.16833/j.cnki.jbmc.2024.06.015
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    Objective: To visually analyze the published literature of traditional Chinese medicine in the treatment of postpartum hypogalactia in CNKI using Citespace 6.1R6, and to summarize the current status, research hotspots and frontier development of traditional Chinese medicine in the treatment of postpartum hypogalactia. Methods: The literature related to the treatment of postpartum hypogalactia by traditional Chinese medicine collected by CNKI from January 1,2010 to December 21,2022 was searched. Citespace 6.1R6 was used to standardize the data based on bibliometrics, and the publication time, authors, institutions and keywords in the literature were visually analyzed and mapped. Results: A total of 464 articles were included, with a time span of 12 years, and the number of publications increased year by year. There were 359 authors in this field, of which 17 were high-frequency authors. The main research teams were ZHANG Shuying's team and LIU Manfang's team. A total of 525 research institutions were included, among which the headquarters and affiliated hospitals of Guangzhou University of Chinese Medicine, the headquarters and affiliated hospitals of Chengdu University of Traditional Chinese Medicine, and the headquarters and affiliated hospitals of Shandong University of Traditional Chinese Medicine were the top three institutions with the largest number of publications. A total of 327 keywords were included, forming 11 cluster labels. The top three keywords were 'lack of milk', 'acupoint massage', 'lactation volume'; there were 4 centrality >0.1. Conclusion: The research hotspots of traditional Chinese medicine in the treatment of postpartum hypogalactia are mostly the clinical efficacy observation literature of external treatment of traditional Chinese medicine, and the basic research is relatively few. It is necessary to strengthen the mining research of basic literature; some institutions have a deep understanding and good research results in this field, but the cooperation between teams and institutions is only internal communication, and there is less cross-regional cooperation. Cross-regional communication and cooperation should be strengthened to carry out deeper theoretical innovation.
  • LIU Yan, ZHANG Xiaomei
    Journal of Baotou Medical College. 2024, 40(6): 86-89. https://doi.org/10.16833/j.cnki.jbmc.2024.06.016
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  • CHU Ning, GAO Fang, JIA Yanbin
    Journal of Baotou Medical College. 2024, 40(6): 90-96. https://doi.org/10.16833/j.cnki.jbmc.2024.06.017
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