25 August 2026, Volume 42 Issue 8
    

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  • Analysis of the drug resistance status and associated influencing factors of pulmonary tuberculosis patients in Tacheng Prefecture Xinjiang
    LI Aiying, HE Shaohong, Yashar Talap, WANG Shumei
    Journal of Baotou Medical College. 2026, 42(8): 1-6. https://doi.org/10.16833/j.cnki.jbmc.2026.08.001
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    Objective: To analyze the drug resistance status and influencing factors of pulmonary tuberculosis patients in Tacheng Prefecture, and to provide reference for local tuberculosis prevention and control. Methods: Patients with bacteriological positive pulmonary tuberculosis who were diagnosed and treated at designated hospitals in Tacheng Prefecture. from January 2022 to January 2023 were selected for strain identification and drug sensitivity test. Logistic regression model was used to analyze the related influencing factors of drug resistance. Results: Among the 510 bacteriological positive pulmonary tuberculosis patients, the rates of monoresistance, multidrug resistance, polyresistance, pre-extensively drug resistance, and extensively drug resistance were 5.7%, 2.4%, 4.7%, 0.6%, and 0.2%, respectively. The drugs with higher resistance rates were ethambutol (2.4%), pyrazinamide (1.8%), rifampicin (1.2%), and rifampicin combined with isoniazid (2.2%). The proportion of drug resistance in patients over 60 years old was higher than that in patients under 60 years old, the proportion of drug resistance in patients unemployed at home and farmers was higher than that in staff patients, the proportion of drug resistance in patients drinking was higher than that in patients not drinking, the proportion of drug resistance in patients not following the doctor ′s advice was higher than that in patients basically following the doctor ′s advice and completely following the doctor ′s advice, and the proportion of drug resistance in retreated patients was higher than that in newly treated patients (all P＜0.05). Multivariate logistic regression analysis showed that age (≥60 years), history of alcohol consumption, basic adherence to medication, non-adherence to prescribed medication, and retreatment were risk factors for the development of drug-resistant tuberculosis. Conclusion: The drug resistance profile of pulmonary tuberculosis patients in Tacheng Prefecture exhibits diverse characteristics. Age ≥60 years, alcohol consumption, poor medication adherence, and retreatment are independent risk factors for the development of drug resistance. Comprehensive drug resistance testing and screening should be implemented to improve the standardization of tuberculosis diagnosis and treatment.
  • Multilevel exploration of the common genetic basis of common cancers and tobacco addiction
    Xin Siyuan, Wang Wei, Chen Wenqing, Wei Yiju, Han Xiaomin, Ma Qiang
    Journal of Baotou Medical College. 2026, 42(8): 7-11. https://doi.org/10.16833/j.cnki.jbmc.2026.08.002
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    Objective: This study aimed to explore the shared genetic architecture between common smoking-related cancers and tobacco addiction, and to identify shared risk loci, key tissues, and underlying genetic mechanisms. Methods: Using summary statistics from large-scale genome-wide association studies (GWAS), we first assessed genetic correlations between multiple cancers and tobacco addiction. Cross-trait pleiotropy analysis was conducted to detect shared pleiotropic loci and genes. Functional annotation and tissue-specific analyses were performed to elucidate potential associations between these complex traits. Heritability enrichment analysis was employed to identify key enriched tissues. Results: Our study revealed shared genetic mechanisms between multiple cancers and tobacco addiction. We identified 291 pleiotropic loci reaching genome-wide suggestive significance, with six leading risk SNPs annotated. Tissue-specific enrichment analyses at both SNP and gene levels implicated brain tissues and bladder as critical contributors to pleiotropic mechanisms. Conclusion: At the genomic level, bladder cancer, non-small cell lung cancer, and small cell lung cancer are genetically related to tobacco addiction; At the organ level, five cancers are genetically enriched in the brain, bladder, and upper gastrointestinal tract along with SNPs of tobacco addiction; At the genetic level, there are 10 common enrichment genes between the five cancers and tobacco addiction.
  • Clinical applicability and application evaluation of the Mongolian Medicine Guideline for the diagnosis and treatment of Alzheimer Disease
    LI Ming, ZHOU Shuangbao, CHEN Hugejiletu, GAN Lina, Siqingmanduhu, SHI Bater, Xiaorong, Aoqier
    Journal of Baotou Medical College. 2026, 42(8): 12-18. https://doi.org/10.16833/j.cnki.jbmc.2026.08.003
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    Objective: To systematically evaluate the clinical applicability and application effect of the Mongolian Medicine Guidelines for Diagnosis and Treatment of Alzheimer′s Disease, and to provide evidence-based basis for the clinical promotion of this guideline. Methods: A questionnaire survey was used to systematically evaluate the current clinical application status, quality level and clinical applicability of the guideline; meanwhile, a prospective case survey method was adopted to evaluate the clinical application effect and application value of the guideline from three aspects: clinical efficacy, medication safety and economic benefits. Results: (1) Clinical compliance rate of the guideline: A total of 180 patients were included in this study. The compliance rates of diagnostic criteria, treatment principles, recommended prescriptions, drug composition, other treatment methods, and daily life and diet conditioning in the guideline all reached 100%, and only the compliance rate of syndrome differentiation was 99.4%. (2) Clinical application effect: The overall effective rate was 88.9%, and the recognition rate of safety and economy was 99.4%. (3) Analysis of correlation and influencing factors: Association rule analysis showed that among the syndrome differentiation and treatment measures including daily life and diet conditioning, treatment principles and prescriptions, prescription had the highest lift value (1.058) for curative effect improvement and the strongest correlation; Logistic regression analysis indicated that guideline satisfaction was an independent influencing factor for safety and economy, with higher satisfaction corresponding to higher safety and economy. Conclusion: The current Mongolian Medicine Guidelines for Diagnosis and Treatment of Alzheimer′s Disease has high compilation quality, is safe and cost-effective, features strong clinical applicability, and possesses good promotion value and clinical application prospect.
  • Study on the application of Lac Operon-Leaky expressed enhanced green fluorescent protein for tracking Salmonella Paratyphi A
    ZHOU Wenhui, LIN Fengming, DING Aijun, ZENG Weikun
    Journal of Baotou Medical College. 2026, 42(8): 19-26. https://doi.org/10.16833/j.cnki.jbmc.2026.08.004
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    Objective: This study aims to construct a plasmid carrying a fused enhanced green fluorescent protein (egfp) gene by utilizing the Lac Operon-Leaky, based on a T-vector. The constructed plasmid will be transformed into Salmonella Paratyphi A (hereinafter referred to as S. Paratyphi A) to obtain recombinant bacteria capable of stably expressing GFP. The tracking efficacy of these bacteria will then be validated using a RAW264.7 macrophage model. This work is intended to provide a visualization tool for subsequent research on the interaction mechanisms between S. Paratyphi A and host cells. Methods: The egfp gene fragment was amplificated by PCR and ligated into pMD18-T vector using a TA cloning strategy and ensured that the inserted egfp gene was in frame with the lacZα peptide reading frame. The correctness of the inserted fragment was confirmed by restriction enzyme digestion and sequencing. The verified recombinant plasmid was then transformed into SPA. The recombinant bacteria were observed under fluorescence microscope, and egfp production was detected by Western blot. The culture curves of recombinant and wild bacteria were compared, evaluating the impact of exogenous gene expression on bacterial growth. Fluorescence stability was assessed by serial single-colony isolation over 20 generations. The intracellular localization of recombinant bacteria was observed via fluorescence microscopy after co-culture with RAW264.7 macrophages. Results: The egfp gene was successfully cloned into the pMD18-T vector. The selected SPA strains exhibited strong green fluorescence under UV light, and egfp expression was confirmed by Western blot. egfp expression did not affect bacterial growth, and the recombinant strains maintained stable fluorescence after 20 generations. Fluorescent microscopy clearly visualized the phagocytized recombinant bacteria within RAW264.7 cells. Conclusion: This study successfully established recombinant SPA strains with stable egfp expression and validated their application in a phagocyte infection model. The fluorescently labeled strain serves as a valuable experimental tool for in-depth research on the pathogenic mechanisms of S. Paratyphi A, host immune responses, and antibacterial drug screening, laying a solid foundation for further investigations.
  • Isolation and antimicrobial potential of endophytic Bacillus velezensis SSF15 from Schisandra sphenanthera fruits
    ZHAO Amujiletu, ZHANG Pengyu, WANG Fei, HE Shan, YU Jingda, GAO Fang, DONG Yanhong, RONG Songhao, MA Shuyi
    Journal of Baotou Medical College. 2026, 42(8): 27-31. https://doi.org/10.16833/j.cnki.jbmc.2026.08.005
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    Objective: To investigate the endophytic bacterial resources in the fruits of Schisandra sphenanthera and evaluate the antimicrobial activity of their metabolites against Escherichia coli, Staphylococcus aureus, and Candida albicans, thereby providing microbial resources for the development of novel natural antimicrobial agents. Methods: Endophytic bacteria were isolated and purified from Schisandra sphenanthera fruits using the tissue isolation method. Antagonistic strains were screened via the Oxford cup method. Statistical analyses were performed using SPSS 27.0 and GraphPad Prism 10 software. The target strain was identified based on morphological characteristics and 16S rDNA gene sequence analysis. Results: A total of 20 endophytic bacterial strains were isolated from Schisandra sphenanthera fruits. Among them, strain SSF15 was selected for its significant broad-spectrum antimicrobial activity. The inhibition zone diameters of the SSF15 fermentation broth against S. aureus, E. coli, and C. albicans were (17.92±0.42) mm, (16.09±0.04) mm, and (17.12±0.04) mm, respectively. Based on 16S rDNA gene sequence alignment, strain SSF15 showed 99.86% homology with Bacillus velezensis and was identified as a member of the genus Bacillus (specifically B. velezensis). Conclusion: The endophytic strain Bacillus velezensis SSF15 from Schisandra sphenanthera fruits demonstrates excellent broad-spectrum antimicrobial activity, indicating its potential as a candidate for developing novel biological antibiotics.
  • The role and bioinformatics analysis of BST1 gene methylation in endometrial carcinoma of the uterine body
    QU Wu, WANG Lizhen
    Journal of Baotou Medical College. 2026, 42(8): 32-40. https://doi.org/10.16833/j.cnki.jbmc.2026.08.006
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    Objective: To systematically screen differentially methylated genes closely related to the occurrence and prognosis of uterine corpus endometrial cancer (UCEC) by integrating multi-omics data and experimental verification, and to explore their potential value as diagnostic markers and therapeutic targets. Methods: Abnormal hypermethylation gene loci in UCEC were screened based on 935 K methylation chip. Combined with TCGA database, survival regression analysis and differential expression analysis were used to further screen key genes. The methylation status of the candidate gene promoter region was verified by methylation specific polymerase chain reaction (MSP). The UALCAN and GSCA databases were used to analyze the expression of key genes and the methylation level of promoter region in UCEC and adjacent normal tissues, as well as the relationship between them. Cox regression and ROC analysis were performed using R software. EPIC tool was used to evaluate the correlation between gene expression and tumor immune microenvironment (TIME). Results: A total of 42 hypermethylated genes were screened by 935 K chip detection, 2 457 genes related to prognosis and 2 700 differentially expressed genes were screened by TCGA database. The intersection of the three data sets further identified bone marrow stromal cell antigen 1 (BST1) as a candidate gene. Bioinformatics analysis showed that the expression of BST1 was down-regulated in UCEC tissues (P＜0.001), and its low expression was related to the improvement of overall survival rate of patients. MSP experiments confirmed that the methylation level of BST1 promoter region in UCEC patients was higher than that in normal tissues (P＜0.001). Correlation analysis based on GSCA and UALCAN platforms showed that the hypermethylation status of BST1 was negatively correlated with its mRNA expression and was significantly correlated with a variety of DNA methylation regulatory factors. In addition, EPIC tool analysis showed that BST1 expression was associated with multiple immune cell infiltration levels in TIME. Conclusion: The hypermethylation of BST1 gene may lead to the down-regulation of its expression, which in turn affects the occurrence and development of UCEC and TIME remodeling. This gene is expected to show the value as a potential biomarker for the diagnosis and prognosis evaluation of UCEC, and provide a theoretical basis for subsequent molecular mechanism research and targeted therapy.
  • The anti-fibrotic effect of human umbilical cord mesenchymal stem cells in interstitial lung disease
    WU Wenqing, MA Yao
    Journal of Baotou Medical College. 2026, 42(8): 41-46. https://doi.org/10.16833/j.cnki.jbmc.2026.08.007
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    Objective: To explore the anti-fibrotic effect of human umbilical cord mesenchymal stem cells (HUMSCs) on the bleomycin (BLM)-induced interstitial lung disease (ILD) model in rats. Methods: Forty-eight SD rats were randomly divided into normal control group (group A), model group (group B), HUMSCs 1×106 cells treatment group (group C), and HUMSCs 3×106 cells treatment group (group D). On the 7th, 14th and 21st day after the establishment of interstitial lung disease model, 4 rats in each group were randomly sacrificed, and the lung tissue was taken for lung coefficient (lung wet weight/body weight ratio) determination and pathological observation. Blood was collected by abdominal aortic puncture, and serum was separated. The contents of IP-10 and TGF-β1 in serum of rats were detected by enzyme-linked immunosorbent assay (ELISA), and the expression level of α-smooth muscle actin (α-SMA) secreted by lung fibroblasts was detected by Western blot. Results: The rat model of interstitial lung disease was successfully established. Compared with group A, the lung coefficient of rats in group B was significantly increased, the lung tissue showed obvious fibrosis changes, the contents of serum IP-10 and TGF-β1 and the expression level of α-SMA in lung tissue were increased (P＜0.05). Compared with group B, the lung coefficient of rats in groups C and D was decreased, the degree of fibrosis in lung tissue was decreased, the content of IP-10 in serum was increased, the content of TGF-β1 was decreased, and the expression level of α-SMA was decreased (P＜0.05). Compared with group C, the lung coefficient of rats in group D was decreased, the degree of fibrosis in lung tissue was decreased, the content of IP-10 in serum was increased, the content of TGF-β1 was decreased, and the expression level of α-SMA was decreased (P＜0.05). Conclusion: Human umbilical cord mesenchymal stem cells can reduce the degree of pulmonary fibrosis, promote the release of IP-10, reduce the content of serum TGF-β1, inhibit the high expression of α-SMA, and the therapeutic effect is more significant with the increase of cell concentration.
  • Expression difference and correlation analysis of peripheral blood CircRNA-STAG1 in patients with acute cerebral infarction
    WANG Yelin, ZHANG Guangwei, LIU Dan
    Journal of Baotou Medical College. 2026, 42(8): 47-52. https://doi.org/10.16833/j.cnki.jbmc.2026.08.008
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    Objective: To investigate the expression of circRNA-STAG1 in peripheral blood of patients with acute cerebral infarction and to analyze the correlation. Methods: Sixty-two patients with acute cerebral infarction whose onset time was less than 7 days were selected as the observation group, and 84 patients without cerebral infarction were selected as the control group. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression level of circRNA-STAG1 in peripheral blood of the two groups. Independent sample t test or chi-square test was used to compare the differences between the two groups. Spearman and Pearson correlation analysis were used to explore the correlation between the target gene and acute cerebral infarction. The clinical data of the two groups were collected, and the risk factors of acute cerebral infarction were analyzed by Logistic regression analysis. Results: The expression level of circRNA-STAG1 in peripheral blood of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P＜0.05). Gender, age, systolic blood pressure, diastolic blood pressure, fasting blood glucose, hypertension history, diabetes history, drinking history and circRNA-STAG1 expression level were positively correlated with the occurrence of acute cerebral infarction. Logistic regression analysis showed that age, fasting blood glucose and peripheral blood circRNA-STAG1 expression level were independent risk factors for acute cerebral infarction (P＜0.05). ROC curve analysis showed that the expression level of circRNA-STAG1 in peripheral blood had certain diagnostic value for acute cerebral infarction. Conclusion: circRNA-STAG1 was an independent risk factor for acute cerebral infarction, with potential application value in the early prevention of acute cerebral infarction.
  • Application of minimally invasive caries removal treatment for deciduous tooth caries in children with dental phobia
    CHENG Huan, YANG Shoudong, CAO Jianhua
    Journal of Baotou Medical College. 2026, 42(8): 53-56. https://doi.org/10.16833/j.cnki.jbmc.2026.08.009
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    Objective: To evaluate the clinical effectiveness of minimally invasive caries removal for deciduous tooth caries in children with dental phobia, aiming to select an effective treatment method to alleviate the anxiety of children with dental phobia and help them smoothly complete the dental diagnosis and treatment process. Methods: A total of 80 children with dental phobia were enrolled as study subjects and randomly divided into an observation group and a control group by simple randomization using a coin toss. The observation group received minimally invasive therapy, in which dental caries in primary teeth was treated with the chemomechanical caries removal agent Carisolv combined with flowable resin; the control group received conventional caries removal with a high-speed turbine handpiece followed by flowable resin restoration. The degree of dental fear, treatment time, and clinical efficacy were compared between the two groups. Results: ①Comparison of fear level: There was no significant difference in fear degree between the two groups before treatment; after treatment, the fear degree of the observation group was significantly lower than that of the control group (P＜0.05). ②Comparison of treatment time: The results of comparison between groups showed that the operation time of the observation group was significantly shorter than that of the control group (P＜0.05). ③Comparison of clinical effects: At the one-year follow-up, there was no statistically significant difference in the restoration loss rate between the two groups (P＞0.05), indicating that Carisolv chemomechanical caries removal was as effective as conventional high-speed turbine handpiece caries removal. Conclusion: Compared with the conventional dental drill group, the minimally invasive group using Carisolv caries removal can more effectively reduce children′s degree of dental fear during dental treatment and shorten the treatment time.
  • Study on the correlation between B cell activatingfactor and the degree of coronary artery disease in coronary heart disease
    LIANG Chunbo, LIN Xuefeng, HAN Xuanmao, BAO Liming
    Journal of Baotou Medical College. 2026, 42(8): 57-62. https://doi.org/10.16833/j.cnki.jbmc.2026.08.010
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    Objective: To investigate the correlation between the level of B-cell activating factor (BAFF) and the severity of coronary artery disease in coronary heart disease, and to provide a new biomarker basis for the diagnosis of coronary heart disease. Methods: A total of 160 patients who underwent coronary angiography (CAG) in the First Affiliated Hospital of Baotou Medical College from January to November 2024 were selected as the research objects, and the general clinical data of the patients were collected. The plasma BAFF level was detected by ELISA. According to the results of coronary angiography, the patients were divided into control group (n=30) and coronary heart disease group (n=130). According to the SYNTAX score, the coronary heart disease group was divided into low-risk group (n=69), medium-risk group (n=38) and high-risk group (n=23). The relationship between BAFF level and the severity of coronary artery disease was analyzed. Results: The concentration of BAFF in patients with coronary heart disease was higher than that in the control group (P＜0.05). The sensitivity and specificity of BAFF in the diagnosis of coronary heart disease were 64.6% and 86.7%, respectively. The plasma BAFF level in the high-risk group and the middle-risk group was higher than that in the low-risk group (P＜0.05). BAFF was an independent risk factor for patients with high SYNTAX score in coronary heart disease, and the sensitivity and specificity of BAFF in the diagnosis of patients with high SYNTAX score in coronary heart disease were 59.0% and 78.8%. Conclusion: BAFF may be involved in the occurrence and development of coronary atherosclerosis, and is closely related to the severity of coronary artery disease. Plasma BAFF level can help predict the presence of coronary heart disease and the severity of coronary artery disease.
  • Clinical study on evaluation of carotid plaque stability in patients with ischemic stroke by the method of multimodal ultrasound
    WANG Chenyi, YAN Guozhen, ZHANG Xiaojun, YUAN Zhiqiang, YUAN Yanfen, REN Na
    Journal of Baotou Medical College. 2026, 42(8): 63-67. https://doi.org/10.16833/j.cnki.jbmc.2026.08.011
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    Objective: To investigate the clinical application value of multimodal ultrasound technology in assessing carotid plaque stability in patients with ischemic stroke (IS). Methods: Using high-resolution carotid magnetic resonance imaging as the gold standard, 80 patients with ischemic stroke accompanied by carotid plaques were selected. They were divided into the stable plaque group (n=55) and the unstable plaque group (n=25). Binary logistic regression analysis was used to analyze the independent risk factors for unstable plaques. The diagnostic efficacy of single ultrasound techniques and multimodal ultrasound was assessed by receiver operating characteristic (ROC) curves. Results: LDL-C was identified as an independent risk factor for plaque instability. The combination of “conventional ultrasound + elastography + contrast-enhanced ultrasound semi-quantitative grading” achieved an AUC of 0.925. After adding LDL-C, the AUC increased to 0.967. Conclusion: Multimodal ultrasound enhances the assessment efficacy of carotid plaque stability in IS patients. The combination of its imaging findings with serum risk factor levels provides a more comprehensive diagnostic basis for clinical practice.
  • The proportion and clinical significance of PD-1+ Tfh and SLAMF7+ Tfh cells in patients with systemic sclerosis
    ZHANG Fengyu, PANG Chunyan, LIU Huiyang, WANG Yongfu
    Journal of Baotou Medical College. 2026, 42(8): 68-74. https://doi.org/10.16833/j.cnki.jbmc.2026.08.012
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    Objective: To analyze the proportions and clinical significance of activated follicular helper T cells (PD-1+ Tfh) and SLAMF7+ follicular helper T cells (SLAMF7+ Tfh) in peripheral blood of patients with systemic sclerosis (SSc). Methods: Thirty-five patients diagnosed with SSc and with a disease course of less than 36 months were enrolled as the observation group, and 35 healthy controls were enrolled as the control group. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IgG, and Scl-70 antibody levels were collected from SSc patients. Additionally, forced vital capacity as a percentage of predicted value (FVC%) and diffusing capacity of the lung for carbon monoxide as a percentage of predicted value (DLCO%) were measured. Imaging (HRCT score) and skin involvement (modified Rodnan skin score) were assessed in SSc patients. The proportions of PD-1+ Tfh and SLAMF7+ Tfh cells in peripheral blood of SSc patients and controls were detected by flow cytometry. GraphPad Prism 10 software was used to analyze differences in the above indicators between the observation and control groups, and to assess their correlations with laboratory parameters and clinical manifestations. Results: Compared with the control group, the proportion of SLAMF7+ Tfh cells in peripheral blood mononuclear cells of SSc patients was significantly increased (P＜0.05), and the proportion of PD-1+ Tfh cells was also significantly increased (P＜0.05). The numbers of SLAMF7+ Tfh and PD-1+ Tfh cells, as well as their proportions within CD4+ T cells, were positively correlated with ESR, IgG, Scl-70, HRCT score, and mRss score, and negatively correlated with FVC% and DLCO% in SSc patients. Conclusion: SLAMF7+ Tfh and PD-1+ Tfh cells may be involved in the pathogenesis of SSc and are potentially linked to fibrosis in SSc, serving as biological indicators for the diagnosis of SSc.
  • Study on the efficacy of dry needlingcombined with blockage in the treatment of piriformis syndrome
    QIAO Jianye, XING Liqing
    Journal of Baotou Medical College. 2026, 42(8): 75-80. https://doi.org/10.16833/j.cnki.jbmc.2026.08.013
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    Objective: To compare the efficacy of dry needling combined with blockage and traditional massage in the treatment of piriformis syndrome. Methods: From May 2023 to May 2024, 36 patients with piriformis syndrome who were treated in the orthopedic clinic of East branch of Baotou Central Hospital were randomly divided into dry needling combined with blockage group and traditional massage group (18 patients in each group). The Visual Analogue Scale (VAS) and the Oswestry Disability Index (ODI) of the two groups before and after treatment were compared. Results: There was no significant difference in gender, age and course of disease between the two groups (P>0.05). After treatment, the VAS score and ODI score of the two groups were lower than those before treatment (P＜0.001), and the scores of the two time points in the dry needling combined with blockage group were significantly higher than those in the traditional massage group (P＜0.001). The total effective rate of dry needling combined with blockage group was significantly different from that of the traditional massage group (χ2=15.231, P＜0.001). Conclusion: Dry needling combined with blockage therapy has significant advantages over traditional massage therapy in relieving pain and improving dysfunction. It provides a more effective scheme for the treatment of piriformis syndrome and is worthy of clinical promotion.
  • Computational insight into myeloid cell leukemia 1 inhibition: a combined ligand-and structure-based approach
    SHI Xuewei, SONG Yu, BAI Qingyang
    Journal of Baotou Medical College. 2026, 42(8): 81-89. https://doi.org/10.16833/j.cnki.jbmc.2026.08.014
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    Objective: To construct a ligand-based pharmacophore model of Mcl-1 protein inhibitors, and analyze the specific binding mode between inhibitors and Mcl-1 protein by molecular docking technology, so as to provide a precise theoretical basis for the design and screening of novel Mcl-1 inhibitors with high activity and selectivity. Methods: Fifteen Mcl-1 inhibitors with different activities (Ki values: 0.45-75 nM) were selected as the training set, and the initial pharmacophore model containing aromatic rings, hydrophobic groups and hydrogen bond acceptors was constructed using the HipHop module of Discovery Studio 3.0 software. The discrimination ability of the model was verified by a test set consisting of 9 active inhibitors and 7 inactive inhibitors. Taking the crystal structure of Mcl-1 protein (PDB:5VKC) as the target, four docking methods including AutoDock, AutoDock Vina, SP Glide and XP Glide (all RMSD ＜ 2 Å, validated effective) were used to analyze the binding characteristics of inhibitors with the protein active cavity, divide three key regions (P2 hydrophobic pocket, P4 hydrophobic pocket and binding site), and further optimize the pharmacophore model. Results: The initially constructed RHHA-type pharmacophore model could effectively distinguish active and inactive inhibitors. Combining with the docking results, the final pharmacophore model with five characteristics (RHHHA: 1 aromatic ring, 3 hydrophobic groups, 1 hydrogen bond acceptor) was obtained through optimization. This model could fully cover the key functional regions of the Mcl-1 protein, and accurately characterize the hydrogen bond interaction between inhibitors and ARG263,π-π stacking with PHE270, and the synergistic binding mode of hydrophobic pockets. Conclusion: Through the combined strategy of ligand-based pharmacophore modeling and structure-based molecular docking, this study clarified the core functional characteristics and binding mechanism of Mcl-1 inhibitors. The optimized pharmacophore model can provide key guidance for the structural optimization, activity screening and selectivity improvement of Mcl-1 inhibitors, and has important application value for overcoming tumor drug resistance and advancing the development of drugs related to cancer treatment.
  • Research progress on respiratory rehabilitation in patients with chronic neck pain
    LI Jun
    Journal of Baotou Medical College. 2026, 42(8): 90-96. https://doi.org/10.16833/j.cnki.jbmc.2026.08.015
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    Chronic neck pain (CNP) is one of the common diseases in the orthopedics department and rehabilitation department. The existing related research mostly focuses on the musculoskeletal system. With the concept of respiratory rehabilitation gradually receiving clinical attention, the research on respiratory function in patients with CNP has gradually increased. Studies have reported that there is a correlation between CNP and respiratory dysfunction, and CNP can be effectively improved by respiratory training, which provides ideas and methods for exploring the changes of CNP respiratory function. Therefore, it is of great clinical significance to explore the relationship between CNP and respiratory dysfunction. This article systematically reviews the correlation between CNP and pulmonary function indicators, respiratory muscle strength, hypocapnia, respiratory pattern, and the current status of respiratory rehabilitation treatment, aiming to provide a reference and basis for respiratory rehabilitation research in CNP patients.
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