25 January 2026, Volume 42 Issue 1
    

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  • Arsenic exposure causes fibrotic changes in lung tissue and an increase in aerobic glycolysis levels
    GAO Shuwen, WU Jinge, XU Shiqing, WANG Li, ZHAO Yuhang
    Journal of Baotou Medical College. 2026, 42(1): 1-5. https://doi.org/10.16833/j.cnki.jbmc.2026.01.001
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    Objective: To investigate whether changes in aerobic glycolysis occur during the process of lung tissue fibrosis induced by arsenic exposure. Methods: At the animal level, mice were allowed to freely drink pure water containing 50 mg/L NaAsO2. After nine months, the mice were sacrificed, and lung tissue sections were prepared for microscopic observation of changes. At the cellular level, HELF cells were exposed to different concentrations of NaAsO2 (0, 10, 20, 40 μmol/L) for 48 hours. Cell viability, glucose consumption were detected, and the gene expression of HK2 and LDHA was detected using qPCR and Western blot. Results: After nine months of arsenic exposure in mice, the alveolar structure of the control group was intact, while the exposed group showed thickening of the tissues around the airways, collagen deposition, and thickening of the alveolar walls. After nine months of NaAsO2 exposure, the relative expression of mRNA and protein of key enzymes of aerobic glycolysis HK2 and LDHA in lung tissue of mice increased compared with the control group (P＜0.05). At the cellular level, after 48 h of exposure, compared with the control group, the viability of HELF cells decreased when the concentration of NaAsO2 was 10, 20, 40 μmol/L (P＜0.05). Glucose consumption increased (P＜0.05). At the RNA level, the expression of HK2 and LDHA increased with the increase of exposure dose (P＜0.05). At the protein level, the expression of HK2 and LDHA increased with the increase of exposure dose (P＜0.05). Conclusion: Aerobic glycolysis may be involved in the process of activation of lung fibroblasts induced by arsenic exposure.
  • The 20-year change of renal biopsy pathological disease spectrum in Baotou, Inner Mongolia
    YU Yuexin, QIN Zirui, LYU Li, WANG Caili
    Journal of Baotou Medical College. 2026, 42(1): 6-10. https://doi.org/10.16833/j.cnki.jbmc.2026.01.002
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    Objective: To analyze the composition and distribution characteristics of renal pathological disease spectrum in Inner Mongolia Autonomous Region in recent 20 years. Methods: The clinicopathological data of patients who underwent renal biopsy in the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology from 2004 to 2023 were collected, and the composition, proportion, change trend and clinical characteristics of renal biopsy pathological types were analyzed. Results: (1)A total of 2 765 renal biopsy cases were included, including 1 477 males (53.4%) and 1 288 females (46.6%).The average age was (45.1±15.7) years old, and the average age increased significantly. (2) The most common primary glomerular disease was membranous nephropathy (31.9%, 881 cases), followed by IgA nephropathy (25.1%, 695 cases) and minimal change nephropathy (10.7%, 296 cases), while the most common secondary glomerular disease was lupus nephritis (4.9%, 134 cases), followed by diabetic nephropathy (3.0%) and purpuric nephritis (2.8%). (3)The proportion of membranous nephropathy and diabetic nephropathy increased significantly in the same period (P＜0.05),while the proportion of IgA nephropathy decreased significantly in the same period (P=0.043), and the proportion of IgA nephropathy in the same period was lower than that of membranous nephropathy after 2014. Conclusion: In the past 20 years, the pathological spectrum of renal biopsy in Inner Mongolia has changed significantly. Since 2014, membranous nephropathy has surpassed IgAN as the most common primary glomerular disease. In addition, diabetic nephropathy is the secondary glomerular disease with the largest growth rate.
  • Analysis of incidence and related factors of fatty liver disease in railway workers
    OU Weili, WANG Meng, REN Zhi, XUE Yongju, WANG Chun, XU Linxia, LI Yan, XU Shanshan
    Journal of Baotou Medical College. 2026, 42(1): 11-15. https://doi.org/10.16833/j.cnki.jbmc.2026.01.003
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    Objective: To explore the prevalence and possible risk factors of fatty liver in railway workers, and to provide data support for the prevention and treatment of occupational diseases. Methods: From January 2024 to June 2024, 2 658 railway workers who underwent physical examination in the physical examination center of the Second Affiliated Hospital of Bengbu Medical University were divided into fatty liver group and non-fatty liver group according to the results of abdominal color Doppler ultrasound. The differences of gender, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and body mass index (BMI) between the two groups were analyzed retrospectively. Logistic multivariate regression model was used to explore the possible risk factors of fatty liver in railway workers. Results: The proportion of males, age, SBP, DBP, BMI, TG, TC, LDL-C and FPG in the fatty liver group were higher than those in the non-fatty liver group, the level of HDL-C was lower than that of non-fatty liver group, and the difference were statistically significant (P＜0.05). Logistic multivariate analysis showed that age, BMI, TG, FPG, obesity (BMI≥28), hypertriglyceridemia, hyperglycemia and hypertension were risk factors for fatty liver (P＜0.05). Conclusion: Fatty liver has a high detection rate in railway workers. Advanced age, obesity, dyslipidemia, elevated blood glucose, and elevated blood pressure are all risk factors for fatty liver.
  • Analysis of spatiotemporal dynamics and antimicrobial resistance trends of klebsiella pneumoniae in Baotou Region, Inner Mongolia
    ZHANG Jing, PENG Zhiping, WANG Xingyu, HUO Dongsheng, GUO Hailun, XU Chaoran, LU Yao, YAN Xiaoxia
    Journal of Baotou Medical College. 2026, 42(1): 16-21. https://doi.org/10.16833/j.cnki.jbmc.2026.01.004
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    Objective: To analyze the clinical distribution and evolution trend of klebsiella pneumoniae (KP) in Baotou, Inner Mongolia. Methods: Retrospective analysis of clinical data and antimicrobial susceptibility profiles of 2 532 klebsiella pneumoniae cases from a tertiary hospital in Baotou from 2017 to 2024 was conducted to investigate temporal dynamics in clinical distribution and evolutionary trends in antimicrobial resistance. Results: From 2017 to 2024, the detection rate of KP exhibited a fluctuating upward trend, accompanied by a progressive annual increase in the proportion of the pneumoniae subspecies (P=0.024). There were differences in the seasonal distribution of KP among different subspecies (P＜0.001). The subspecies of pneumonia were mainly distributed in autumn, and the other subspecies were mainly distributed in spring and winter. KP was mainly found in middle-aged and elderly patients (P＜0.001), and reached the highest value in the 60 to 69 age group. General surgery, respiratory department, neurology department and ICU were the main departments where KP was detected (P＜0.001). The main specimens were sputum, secretions, urine and venous blood. The detection rates of carbapenem-resistant klebsiella pneumoniae and hyper-spectral β-lactamase klebsiella pneumoniae increased year by year (P＜0.001). Except for some cephalosporin drugs cefazolin, the resistance of pneumonia subspecies to other antimicrobial agents was higher than that of other subspecies (P＜0.001). The resistance rate of KP to polymyxin B was low (0.00%-0.40%), and the average resistance rates to imipenem and meropenem were 4.90% and 4.80%, respectively. The resistance to other antibiotics showed an increasing trend year by year (P＜0.001). Conclusion: The clinical detection of KP increased year by year. KP was significantly different in different subspecies, gender, season, age, department and sample type. Polymyxin B was the most suitable drug. The resistance of KP to other drugs showed an increasing trend.
  • Optimization and improvement of quality standards for Bengbare-7 flavor pills
    ZHANG Yuqing, GUO Ye, GUO Jingjing, YANG Yufei, ZHANG Qirui, AN Ming
    Journal of Baotou Medical College. 2026, 42(1): 22-27. https://doi.org/10.16833/j.cnki.jbmc.2026.01.005
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    Objective: To optimize and improve the quality standards of the Mongolian medicine Bengbare-7 flavor pills. Methods: Microscopic identification was carried out for four medicinal materials including Cinnamomi Cortex, Kaempferiae Rhizoma, Aucklandiae Radix and Lycii Fructus in Mongolian medicine Bengbare-7 flavor pills. Thin layer chromatography (TLC) method was used for the qualitative identification of Lycii Fructus, Aucklandiae Radix and Cinnamomi Cortex. High performance liquid chromatography (HPLC) method was adopted to determine the content of cinnamaldehyde, the main component in Cinnamomi Cortex. The mobile phase was acetonitrile-water (34∶66), the column temperature was 25 ℃, the detection wavelength was 290 nm, and the flow rate was 1.0 mL/min. Results: The powder characteristics of Cinnamomi Cortex, Kaempferiae Rhizoma, Aucklandiae Radix and Lycii Fructus had been distinct in the microscopic identification of Bengbare-7 flavor pills. TLC detection showed that the test sample and the reference substance showed characteristic spots of the same color at the same chromatographic position, and the negative control sample did not show speckle interference. with good specificity. The peak area of cinnamaldehyde had a good linear relationship in the concentration range of 7.38-21.95 μg/mL, and the regression equation was y=0.483 9x-0.454 6 ( R2=0.999 1), the average recovery was 101.4%, 100.4%, 102.1%, RSD was 0.84%, 0.35%, 0.44%. Conclusion: The microscopic identification, thin layer chromatography identification and content determination method of Mongolian medicine Bengbare-7 flavor pills constructed in this study have been verified to have accuracy, high sensitivity, good repeatability and precision, and excellent specificity, which can effectively help the improvement and optimization of the quality standard of Mongolian medicine preparation.
  • The potential mechanism of Cheqianzi in improving renal fibrosis based on network pharmacology and molecular docking technology
    XU Nanbing, WU Guodong, ZHAO Longshan, BO Yukun, YANG Dan, GUO Jingjing, ZHU Junxuan, AN Ming
    Journal of Baotou Medical College. 2026, 42(1): 28-34. https://doi.org/10.16833/j.cnki.jbmc.2026.01.006
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    Objective: Prediction of the mechanism of psyllium in improving renal fibrosis based on network pharmacology and molecular docking technology. Methods: The active ingredients of psyllium were queried and screened through the TCM Systematic Pharmacological Analysis Platform (TCMSP), and the targets of its active ingredients were predicted according to Pubchem and Swiss Target Prediction. Renal fibrosis-related targets were queried in GeneCards and OMIM, and the intersecting targets were mapped with the active ingredient targets. The protein-protein interaction (PPI) network of the intersecting targets was constructed by STRING and Cytoscape 3.7.2, and the GO and KEGG pathways enrichment analysis and visualization were performed by DAVID and microbiosis, and the psyllium-component-target-disease network diagram was constructed by Cytoscape 3.7.2 to predict its anti-renal fibrosis mechanism. Finally, the molecular docking technology verified the docking of the active ingredient and the protein, and further explored the mechanism of psyllium to improve renal fibrosis. Results: 455 targets of 9 active ingredients were obtained from psyllium, and 256 intersecting targets were obtained by intersecting with disease targets. GO and KEGG pathway enrichment analysis showed that psyllium mainly improved renal fibrosis through biological processes such as cancer pathway, PI3K-Akt and Rap1 signaling pathway, cell proliferation, inflammatory response and cell migration. Molecular docking analysis showed that the active ingredient was stably bound to the core target. Conclusion: In this study, it was found that psyllium mainly acts on core targets such as VEGFA, TNF, ALB, AKT1, IL-6 and EGFR, and plays an anti-renal role in reducing inflammatory responses, inhibiting cell proliferation and migration through cancer pathways, PI3K-Akt and Rap1 signaling pathways.
  • The mechanism of Trollius chinensis Bunge in the treatment of chronic sinusitis based on network pharmacology and molecular docking
    ZHOU Yuqian, DU Yan, YANG Meiqing
    Journal of Baotou Medical College. 2026, 42(1): 35-41. https://doi.org/10.16833/j.cnki.jbmc.2026.01.007
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    Objective: To explore the mechanism of Trollius chinensis Bunge in the treatment of chronic sinusitis by network pharmacology and molecular docking. Methods: Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and other databases were used to screen the active ingredients and potential targets in Trollius chinensis Bunge. GeneCards and other databases were used to search for disease-related targets; the compound target-disease Venn diagram was constructed, and the intersection target between drug target and disease target was obtained. Cytoscape 3.9.1 software was used to draw the drug-component-target-disease network diagram. The PPI network diagram of protein-protein interaction was constructed by STRING database and Cytoscape. R4.2.1 software clusterProfiler package was used to perform gene ontology (GO) function and kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis, and Cytoscape was used to construct a drug-component-target-pathway network diagram. Molecular docking of key active ingredients and core targets was performed using AutoDockTools. Results: Through database screening, 14 active ingredients, 507 active ingredient targets, 829 disease-related targets and 160 common targets were obtained. Quercetin, acacetin, β-sitosterol, dihydroquercetin and luteolin were the core components of Trollius chinensis Bunge in the treatment of chronic sinusitis. Protein interaction network analysis showed that the core targets may be through signal transducer and activator of transcription 3 (STAT3), the tumor necrosis factor (TNF), interleukin-6 (IL-6), TP53, AKT1, SRC and other six core targets. GO and KEGG enrichment analysis showed that STAT3, TNF, IL-6 and other signaling pathways played an anti-inflammatory role. The results of molecular docking showed that the core components of Trollius chinensis had good binding ability with the core targets. Conclusion: Quercetin, acacetin, β-sitosterol and other active ingredients in Trollius chinensis Bunge may regulate STAT3, IL-6, TNF, TP53, AKT1, SRC and other targets to regulate multiple signaling pathways, reduce the secretion of inflammatory factors, regulate the occurrence and development of inflammation, so as to play a role in the treatment of chronic sinusitis.
  • Effect of isoliquiritigenin on the migration of gastric cancer cells
    SHEN Yingxue, DONG Wenjie, GAO Fang, JIA Yanbin
    Journal of Baotou Medical College. 2026, 42(1): 42-46. https://doi.org/10.16833/j.cnki.jbmc.2026.01.008
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    Objective: To investigate the effect of isoliquiritigenin on the migration of gastric cancer cells and its possible mechanism. Methods: The cultured gastric cancer cells HGC-27 were divided into control group, 50 μmol/L ISL group and 75 μmol/L ISL group, and AGS cells were divided into control group, 100 μmol/L ISL group and 150 μmol/L ISL group. The number of cells migrated in each group was detected by scratch test and Transwell migration test. The mRNA expression levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in each group were determined via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results: As the concentration of isoliquiritigenin rose, there was a marked reduction in the migratory cell counts of HGC-27 and AGS cells (P＜0.05). RT-qPCR results showed that the relative expression levels of MMP-2 and MMP-9 mRNA in Isoliquiritigenin intervention groups were significantly lower than those in blank control group (P＜0.05). Conclusion: Isoliquiritigenin may inhibit the migration of HGC-27 and AGS by decreasing the MMP-2 and MMP-9 expression.
  • Role of FRMD4B in pan-cancer and its association with prognosis and immune microenvironment
    WANG Zizhen,XU Hao,QIAN Gege, LI Jiahui, ZHANG Yao, BAI Zijian, ZHANG Wen, LI Xinyi, RUI Yutong, CHEN Bing
    Journal of Baotou Medical College. 2026, 42(1): 47-55. https://doi.org/10.16833/j.cnki.jbmc.2026.01.009
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    Objective: To investigate the role of the FRMD4B gene in various cancers and its association with prognosis, immune microenvironment. Methods: Data of 33 tumors were obtained from TCGA and UCSC Xena databases and analyzed FRMD4B in Perl and R. Evaluated its correlation with prognosis, clinical phenotype, tumor mutation burden (TMB), microsatellite instability (MSI), immune infiltration. And explored its mutational characterization, subcellular localization, and more with online tools. Results: The expression level of FRMD4B mRNA in various tumor tissues was lower than that in corresponding normal tissues (P＜0.001). The results of four survival analysis showed that FRMD4B expression was associated with tumor-specific survival (P＜0.05). In some tumors, FRMD4 B showed different correlations with TMB, MSI, matrix score and immune score (P＜0.05). FRMD4B expression exhibited varying degrees of correlation with TMB, MSI, stromal score and immune score in different tumor types(P＜0.05). Immunohistological analysis showed that FRMD4B was significantly correlated with immune cells in a variety of tumors(P＜0.001) and positively correlated with the majority of immune-related genes. Gene-set enrichment analysis showed that high expression FRMD4B was significantly enriched in biological processes such as immune pathways and cell cycle. Its mutations were mainly missense mutations. Its interacting proteins included CYTH1, GPA33, HSPB7 and PLEKHA5. The subcellular localization was primarily observed in the cytoplasmic and cytoskeletal regions. Conclusion: FRMD4B plays a critical role in a variety of cancers and is closely related to tumor development, prognosis and immune environment. It may become a potential biomarker and therapeutic target for precision cancer therapy.
  • Effect and mechanism of LKB1 on the proliferation, migration and invasion of lung cancer cells
    ZHAO Zongting, WANG Xinxin, JIA Jianxin, CHEN Xiaoyan
    Journal of Baotou Medical College. 2026, 42(1): 56-61. https://doi.org/10.16833/j.cnki.jbmc.2026.01.010
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    Objective: To investigate the effect of liver kinase B1 ( LKB1 ) gene on the proliferation, migration and invasion of lung cancer cells and its mechanism. Methods: LKB1 overexpression lentivirus was transfected into A549 cells, and A549 blank group (without transfection of lentivirus), NC-A549 group (transfected with empty vector) and LKB1-A549 group (transfected with LKB1 gene) were established. Western blot and RT-qPCR were used to detect the expression level of LKB1 after transfection. CCK8 assay was used to detect the effect of LKB1 overexpression on the proliferation of A549 cells. Transwell assay was used to detect the effect of LKB1 overexpression on the migration and invasion of A549 cells. The effect of LKB1 overexpression on the expression of epithelial-mesenchymal transition markers was detected by RT-qPCR. The effects of LKB1 overexpression on the expression of vascular endothelial growth factor A and tropomyosin 1 were detected by Western blot. Results: Compared with the A549 blank group, the expression of LKB1 in the LKB1-A549 group was increased (P＜0.01), the cell proliferation, migration and invasion abilities were decreased (P＜0.01), the expression of epithelial-mesenchymal transition marker E-cadherin was increased (P＜0.01), and the expression of N-cadherin was decreased (P＜0.01). The expression of vascular endothelial growth factor A (VEGFA) and tropomodulin-1 (TMOD1) decreased (P＜0.01). Conclusion: LKB1 overexpression inhibits the proliferation, migration, invasion, epithelial-mesenchymal transition and angiogenesis of human lung cancer A549 cells, which may become a potential target for lung cancer treatment.
  • The expression difference and correlation analysis of circGRHPR in atherosclerotic cerebral infarction
    JIANG Xiaoling,LIU Bo, LIU Dan, ZHANG Guangwei
    Journal of Baotou Medical College. 2026, 42(1): 62-68. https://doi.org/10.16833/j.cnki.jbmc.2026.01.011
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    Objective: To analyze the expression and clinical value of circGRHPR in peripheral blood of patients with atherosclerotic cerebral infarction. Methods: A total of 81 patients diagnosed with atherosclerotic cerebral infarction from June 2021 to October 2024 were used as the experimental group, and 81 healthy subjects were used as the control group. The clinical data of the experimental group and the control group were collected, including gender, age, history of disease, history of tobacco and alcohol, blood biochemical indicators, etc. The copy number of circGRHPR in peripheral blood was calculated by quantitative PCR. Pearson correlation was used to analyze the correlation between circGRHPR and atherosclerosis cerebral infarction, and Logistic regression analysis was used to analyze the independent risk factors of atherosclerosis cerebral infarction. Results: There were significant differences in blood pressure, cholesterol level, high-density lipoprotein level and drinking history between the two groups (P＜0.05). The expression level of circGRHPR in peripheral blood of patients in the experimental group was significantly higher than that in the control group (P＜0.05). Gender, age, systolic blood pressure, diastolic blood pressure, cholesterol level, history of hypertension, smoking history, drinking history and expression level of circGRHPR in peripheral blood were positively correlated with the occurrence of atherosclerotic cerebral infarction (P＜0.05). There was no collinearity relationship among variables in collinearity statistics. The area under the curve of the expression level of circGRHPR in peripheral blood of patients with atherosclerotic cerebral infarction was 0.692, the sensitivity was 0.92, and the specificity was 0.51. Binary Logistic regression analysis showed that the independent risk factors of patients were gender, age, systolic blood pressure, diastolic blood pressure, history of hypertension, smoking history, drinking history and circGRHPR expression level in peripheral blood (P＜0.05). Conclusion: circGRHPR expression in peripheral blood of patients with atherosis cerebral infarction is up-regulated, which can be used as an ideal biomarker for the diagnosis of atherosis cerebral infarction, and may also be a potential target for therapeutic intervention.
  • Study on gender differences and perimenopausal effects of MRI IDEAL-IQ quantitative parameters in lumbar osteoporosis
    WANG Mengjiao, LIU Zhenzhen, CHEN Qiang, WU Chunyan, LUO Lin
    Journal of Baotou Medical College. 2026, 42(1): 69-74. https://doi.org/10.16833/j.cnki.jbmc.2026.01.012
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    Objective: To investigate the correlation between magnetic resonance iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence (IDEAL-IQ) parameters [fat fraction (FF) and R2* relaxation rate] and bone mineral density (BMD), to analyze their differences between sexes, and to specifically evaluate the evolution of the bone marrow microenvironment in perimenopausal women. Methods: The data of 65 subjects who underwent lumbar DXA and 3.0T MRI were retrospectively analyzed. According to the DXA T value, the patients were divided into normal bone mass group, osteopenia group and osteoporosis group. Male subjects were included as gender controls, and the differences in IDEAL-IQ parameters between different genders were compared. The female subjects were further grouped according to the years of menopause, and the dynamic changes of FF and R2 * values were analyzed. Results: (1) At the overall level: with the loss of bone mass, the FF value increased (P＜0.001) and the R2* value decreased (P＜0.001), both of which were highly correlated with BMD (P＜0.001). The efficacy of R2* in the diagnosis of osteoporosis (AUC=0.887) was better than that of FF. (2) Gender differences: The vertebral R2* value of female was lower than that of male (P＜0.05), suggesting that there was a specific decrease in bone marrow iron reserve and microstructure magnetic sensitivity in women. There was no significant difference in FF value between the male and female (P＞0.05). (3) Perimenopausal characteristics: The FF value of female increased with the extension of menopausal years (P＜0.05), which was manifested as the rapid accumulation of bone marrow fat in early menopause. Conclusion: IDEAL-IQ technology can noninvasively and quantitatively evaluate the changes of bone marrow fat metabolism. R2* value is a sensitive index to reflect the gender difference of osteoporosis, and FF value can sensitively capture the bone marrow transformation process of perimenopausal women. This technology is expected to be an effective supplement to DXA, especially for early screening of perimenopausal women.
  • Prognostic value of 18F-FDG PETCT metabolic parameters combined with serum SALL4 level in patients with gastric cancer
    ZHENG Kechuang, WANG Ziwen, YUAN Longtao
    Journal of Baotou Medical College. 2026, 42(1): 75-79. https://doi.org/10.16833/j.cnki.jbmc.2026.01.013
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    Objective: To explore the prognostic value of 18F fluorodeoxyglucose positron emission computed tomography (18F-FDG PETCT) metabolic parameters combined with serum spalt-like transcription factor 4 (SALL4) level in patients with gastric cancer. Methods: A study was conducted on 59 gastric cancer patients who visited our hospital from April 2022 to January 2024. The 18F-FDG PETCT metabolic parameters and serum SALL4 levels of the 59 gastric cancer patients were statistically analyzed upon admission. The 18F-FDG PETCT metabolic parameters and serum SALL4 level of patients with different pathological types were compared, and the correlation was analyzed using Spearman's method. The metabolic parameters of 18F-FDG PETCT and serum SALL4 level in patients with different prognosis were compared, and the predictive value of the indicators for the prognosis of patients was analyzed. Results: The SUVmax of 59 patients with gastric cancer was 7.1(5.07,10.85), the MTV was 12.4(6.73,23.15)cm3, the TLG was 50.8(18.74,187.26)g, and the serum SALL4 level was 285.7(247.82,312.57)pg/mL. Comparison of SUVmax, MTV, TLG and serum SALL4 level: low differentiation＞moderate and high differentiation, stage Ⅲ-Ⅳ＞stage Ⅰ-Ⅱ, lymph node metastasis＞no lymph node metastasis (P＜0.05). SUVmax, MTV, TLG and serum SALL4 level were positively correlated with clinical stage and lymph node metastasis (P＜0.05), and negatively correlated with the degree of differentiation (P＜0.05). The levels of SUVmax, MTV, TLG and serum SALL4 in patients with good prognosis were lower than those in patients with poor prognosis (P＜0.05). The AUC of the combined prediction of 18F-FDG PETCT metabolic parameters and serum SALL4 level was 0.864, the best predictive sensitivity was 92.31%, and the specificity was 80.43%. Conclusion: Both 18F-FDG PETCT metabolic parameters and serum SALL4 level are closely related to different clinicopathological features of gastric cancer patients, which can provide an effective reference for clinical prediction of prognosis of gastric cancer patients.
  • Modified methods for determining bacterial growth curves based on tube culture and microplate reader
    HUO Chenhui, PAN Xiangying, CAI Lin, YU Yangyang, ZHAO Jia, MAO Yixuan, ZHANG Meiying
    Journal of Baotou Medical College. 2026, 42(1): 80-84. https://doi.org/10.16833/j.cnki.jbmc.2026.01.014
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    Objective: To optimize the bacterial growth curve determination method and systematically evaluate the effects of detection devices (spectrophotometer vs. microplate reader), culture methods (batch vs. aliquoted tube), and detection timing (real-time vs. endpoint) on growth curve analysis. Methods: Using Escherichia coli and Staphylococcus aureus as model strains, a three-factor orthogonal experimental design (8 combinations) was implemented. Optical density values were measured via spectrophotometer (OD600) and microplate reader (OD630) to plot growth curves. The growth curve was drawn and the correlation between devices, time sequence equivalence and culture stability were analyzed. Results: Growth curves under different method combinations showed strong positive correlations (P＜0.01). No significant differences were observed between real-time and endpoint refrigeration detection in OD values (P＞0.05). The optimized tube culture-endpoint-microplate reader (OD630) detection method significantly improved the smoothness of the curve by pre-mixed inoculation standardization and single-tube continuous sampling. Conclusion: The integrated protocol combining tube pre-mixed culture, 4 ℃ refrigeration endpoint detection, and microplate reader-based high-throughput analysis (OD630) improves operational efficiency and data consistency, providing an optimization scheme for bacterial growth curve determination.
  • Research progress on tuberculosis vaccines based on recombinant viral vectors
    WANG Jianghong, WANG Xiaochun, XIA Lu, PI Xinxin, WU Jiagao
    Journal of Baotou Medical College. 2026, 42(1): 85-90. https://doi.org/10.16833/j.cnki.jbmc.2026.01.015
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    Tuberculosis is still a serious public health threat around the world. However, bacillus calmette-guérin (BCG), the only licensed vaccine, has limited efficacy. In recent decades, viral vector vaccines have developed rapidly. Recombinant live virus vector vaccine can simulate the process of pathogen invasion and induce immune response, and has the ability to form long-term immune memory and strong immune protection. This paper reviews the latest research progress of tuberculosis virus vector vaccines, systematically reviews the tuberculosis virus vector vaccines undergoing clinical trials, and evaluates and summarizes the candidate vaccines with development potential in the early stage of development. This article may provide theoretical and practical support for the development of a more effective tuberculosis recombinant virus vector vaccine.
  • Research progress of the uric acid to high-density lipoprotein cholesterol ratio in the cardiovascular diseases
    LIN Xiangjun, LIU Tao, ZHANG Jiachun, XIANG Jia, HE Jiaqi, ZHU Feng
    Journal of Baotou Medical College. 2026, 42(1): 91-96. https://doi.org/10.16833/j.cnki.jbmc.2026.01.016
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    Cardiovascular disease is one of the leading causes of death in the world. Serum uric acid level and high-density lipoprotein cholesterol level are two important factors affecting cardiovascular health. Recent studies have found that serum uric acid to high-density lipoprotein cholesterol ratio ( UHR ) can better reflect the risk and prognosis of cardiovascular disease. This article reviews the clinical application value of UHR in cardiovascular diseases in recent years, and provides reference for clinical diagnosis and treatment.
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