Objective: To analyze the association between the single nucleotide polymorphism (SNP) rs7217186 of the arachidonate 15-lipoxygenase (ALOX15) gene and the infection of Helicobacter pylori (H.pylori) as well as the risk of non-cardia gastric cancer. Methods: We performed a case-control study involving 458 patients with non-cardia gastric cancer and 460 healthy controls from the Han Chinese population in Baotou. H.pylori infection status in controls was assessed using both the 14C-urea breath test (UBT) and enzyme-linked immunosorbent assay (ELISA). Genotyping of ALOX15 rs7217186 was conducted via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The potential associations between this genetic variant and H.pylori infection or gastric cancer risk were evaluated using unconditional logistic regression analysis. Results: A total of 460 controls were tested for H.pylori infection, the positive rate was 42.3%.ALOX15 rs7217186 was not associated with infection by H.pylori. ALOX15 rs7217186 was not associated with the risk of non-cardia gastric cancer. Conclusion: ALOX15 rs7217186 polymorphism may not significantly contribute to H.pylori infection susceptibility or non-cardia gastric cancer risk.
CHU Ning
,
DONG Wenjie
,
GAO Fang
,
LI Yingze
,
CHEN Yaru
,
JIA Yanbin
. Association of ALOX15 gene rs7217186 polymorphism with non-cardia gastric carcinogenesis[J]. Journal of Baotou Medical College, 2025
, 41(7)
: 59
-63
.
DOI: 10.16833/j.cnki.jbmc.2025.07.011
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