Objective: To explore the effect of mevalonate diphosphate decarboxylase a (mvda) on the myocardial regeneration of zebrafish. Methods: On the 6th day after fertilization, the zebrafish embryos of the control group (DMSO), MTZ-treated myocardial injury group (MTZ), MTZ-treated group after mvda knock-out (mvda MO+MTZ) and MTZ-treated group after mvda overexpression (mvda OE+MTZ) were detected by confocal laser scanning microscopy. Results: Adding MTZ led to myocardial ablation of zebrafish. Compared with the MTZ group, mvda knocked-down could inhibit myocardial regeneration of zebrafish(P＜0.05), while regeneration ratio of ventricular in zebrafish with overexpression of mvda was higher(P＜0.05). It was found that zebrafish with overexpression of mvda had a higher rate of heart rate recovery to normal level than those with MTZ injury and mvda knocked down (P＜0.05). Zebrafish with overexpression of mvda could improve myocardial regeneration and promote recovery of cardiac function. Conclusion: Mvda can regulate the myocardial regeneration of zebrafish.
CHEN Xianghui
,
LIN Yufeng
,
LI Xiaoting
,
LYU Xuehao
,
SUN Jiajun
,
GU Xinyue
,
WANG Wenxuan
,
LI Yimin
,
JIA Xiaoe
,
ZHU Wei
. Regulation effect of mvda in myocardial regeneration of zebrafish[J]. Journal of Baotou Medical College, 2025
, 41(7)
: 44
-48
.
DOI: 10.16833/j.cnki.jbmc.2025.07.008
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