A study on the correlation between anxiety, depression scores    and gastrointestinal symptoms in patients with gastrointestinal    diseases in rural areas

  • YANG Xin ,
  • YANG Ningjing ,
  • XU Jia ,
  • SHEN Xingrong ,
  • WANG Debin
Expand
  • 1. School of Health Service Management, Anhui Medical University, Hefei 230032, China;
    2. Center for Health Service and Management Appropriate Technology Research, Anhui Medical University

Received date: 2024-07-25

  Online published: 2025-08-06

Abstract

Objective: To explore the correlation between anxiety, depression symptoms and gastrointestinal symptoms in patients with gastrointestinal diseases in rural areas of Fuyang City and Bozhou City in Anhui Province. Methods: Using stratified random sampling method, 40 township hospitals were selected from Fuyang and Bozhou cities in Anhui province. A face-to-face survey was conducted among 309 gastrointestinal patients who met the inclusion criteria. Spearman rank correlation test and negative binomial regression model were used to analyze the association between patients’ anxiety, depression symptoms and gastrointestinal symptoms. Results: Among patients with at least one gastrointestinal symptom, the detection rates of anxiety symptoms and depression symptoms were 30.3% and 46.9%, respectively. Spearman rank correlation analysis showed that the duration of swallowing discomfort and loose stool were positively correlated with anxiety symptom score (rs=0.441, 0.263, P<0.05); the duration of hiccups or belching, postprandial mood swings, and the frequency of abdominal pain per year were positively correlated with depression symptom score (rs=0.289, 0.306, 0.273, P<0.05). The negative binomial regression analysis results showed that age, history of hospitalization in the past three months, history of gastrointestinal drug use in the past month, anxiety symptom scor, and depression symptom scor were influencing factors of the number of gastrointestinal symptoms (P<0.05). Conclusion: Patients presenting with at least one gastrointestinal symptom exhibit a higher detection rate of anxiety and depressive symptoms. Furthermore, the severity of anxiety and depression correlates with the number of gastrointestinal symptoms reported. Primary care doctors should pay attention to the screening and intervention of anxiety, depression and other psychological disorders in patients with gastrointestinal diseases.

Cite this article

YANG Xin , YANG Ningjing , XU Jia , SHEN Xingrong , WANG Debin . A study on the correlation between anxiety, depression scores    and gastrointestinal symptoms in patients with gastrointestinal    diseases in rural areas[J]. Journal of Baotou Medical College, 2025 , 41(7) : 1 -6 . DOI: 10.16833/j.cnki.jbmc.2025.07.001

References

[1] 宋佳, 罗雨欣, 郭金波, 等. 2018年消化系统疾病主要临床进展[J]. 临床荟萃, 2019, 34(1): 41-48.
[2] Clevers E, Lutin E, Cornelis J, et al. Gastrointestinal symptoms in office workers are predicted by psychological distress and short sleep duration[J]. J Psychosom Res, 2020, 138: 110230.
[3] 陈胜良. 肠道微生态与功能性胃肠病[J]. 临床内科杂志, 2016, (10): 3.
[4] Söderquist F, Syk M, Just D, et al. A cross-sectional study of gastrointestinal symptoms, depressive symptoms and trait anxiety in young adults[J]. BMC Psychiatry, 2020, 20(1): 535.
[5] 罗志成. 河南农村人群抑郁和焦虑症状的流行特征及其影响因素[D]. 郑州: 郑州大学, 2021.
[6] Black CJ, Drossman DA, Talley NJ, et al. Functional gastrointestinal disorders: advances in understanding and management[J]. Lancet, 2020, 396(10263): 1664-1674.
[7] Perera MJ, Schneiderman N, Sotres-Alvarez D, et al.Are Anxious and Depressive Symptoms Associated with Gastrointestinal Symptoms in the Hispanic community health study/study of latinos(HCHS/SOL)[J]. J Racial Ethn Health Disparities, 2021, 8(3): 712-722.
[8] Spitzer RL, Kroenke K, Williams JB, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7[J]. Arch Intern Med, 2006, 166(10): 1092-1097.
[9] Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure[J]. J Gen Intern Med, 2001, 16(9): 606-13.
[10] 朱俊亮, 黄蓉蓉, 刘红波. 零膨胀负二项回归模型在医学研究中的应用[J]. 中国卫生统计, 2022, 39(5): 736-740.
[11] Huang Y, Wang Y, Wang H, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2019, 6(3): 211-224.
[12] Chen Y, Lian B, Li P, et al. Studies on irritable bowel syndrome associated with anxiety or depression in the last 20 years: a bibliometric analysis[J]. Front Public Health, 2022, 10: 947097.
[13] 魏薇, 费贵军. 焦虑抑郁状态在肠易激综合征发病机制中的作用[J]. 中国实用内科杂志, 2018, 38(1): 77-80.
[14] 杨军韦, 梁杰, 刘敬文, 等. 焦虑障碍、抑郁障碍患者的睡眠质量及与焦虑、抑郁症状的相关性[J]. 神经疾病与精神卫生, 2022, 22(3): 166-171.
[15] 徐慧慧, 陈煦, 赵芳, 等. 饮食结构、营养成分对抑郁症的影响研究进展[J]. 食品科学, 2022, 43(23): 346-355.
[16] Wang S, Tan C, Liu C, et al. Common gastrointestinal symptoms and their impact on psychological state and quality of life in patients with inflammatory bowel disease: a cross-sectional multicenter study in China[J]. Gastroenterol Rep (Oxf), 2024, 12: goae019.
[17] Mussell M, Kroenke K, Spitzer RL, et al. Gastrointestinal symptoms in primary care: prevalence and association with depression and anxiety[J]. J Psychosom Res, 2008, 64(6): 605-612.
[18] Pinto-Sanchez MI, Ford AC, Avila CA, et al. Anxiety and depression increase in a stepwise manner in parallel with multiple FGIDs and symptom severity and frequency[J]. Am J Gastroenterol, 2015, 110(7): 1038-1048.
[19] 陈启仪, 路聚保, 秦环龙, 等.“胃肠精神病学”的临床意义与干预策略[J]. 中华胃肠外科杂志, 2022, 25(9): 771-776.
[20] Ma T, Xue X, Tian H, et al. Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms[J]. J Transl Med, 2023, 21(1): 349.
[21] Hughes L.Effects of bedrest 3: gastrointestinal, endocrine and nervous systems[EB/OL]. (2019-01-21)[2025-02-28]. https://www.nursingtimes.net/gastroenterology/effects-of-bedrest-3-gastrointestinal-endocrine-and-nervous-systems-21-01-2019.
[22] Zhang H, Wang Z, Wang G, et al. Understanding the connection between gut homeostasis and psychological stress[J]. J Nutr, 2023, 153(4): 924-939.
[23] Zhang X, Li Q, Xia S, et al. Proton pump inhibitors and oral-gut microbiota: from mechanism to clinical significance[J]. Biomedicines, 2024, 12(10): 2271.
[24] Ivey KJ. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. actions of therapeutic agents[J]. Am J Med, 1988, 84(2A): 41-8.
Outlines

/