目的:探讨帕金森病(PD)合并认知障碍的患者血尿酸(UA)及血同型半胱氨酸(Hcy)水平的临床意义。方法:选择2017年1月至2022年1月就诊的96例PD患者,根据蒙特利尔认知评价量表评分结果分为三组,A组为PD认知正常组(34例),B组为PD轻度认知障碍组(32例),C组为PD痴呆组(30例)。D组为对照组,由健康体检者组成(50例)。检测各组血UA及Hcy水平,并分析各指标差异的意义。结果:与D组相比,A、B、C3组患者UA水平低,Hcy水平高,差异有统计学意义(P＜0.01);与A组比较,B组、C组UA水平低,Hcy水平高,差异有统计学意义(P＜0.05);C组UA水平低于B组,Hcy水平高于B组(P＜0.05)。结论:PD患者UA降低、Hcy水平增高可能在一定程度上反映了PD患者认知功能损害的程度。
Objective: To investigate the clinical significance of serum uric acid (UA) and homocysteine (Hcy) levels in patients with Parkinson′s disease (PD) complicated with cognitive impairment. Methods: A total of 96 patients with PD who were admitted from January 2017 to January 2022 were selected and divided into three groups according to the Montreal Cognitive Assessment Scale score. Group A was the PD cognitive normal group (34 patients), group B was the PD mild cognitive impairment group (32 patients), and group C was the PD dementia group (30 patients). Group D was the control group, which was composed of healthy subjects (50 patients). The levels of UA and Hcy in each group were detected, and the significance of the differences in each index was analyzed. Results: Compared with group D, the level of UA was lower and the level of Hcy level were higher in groups A, B and C, and the differences were statistically significant (P＜0.01). Compared with group A, the level of UA was lower and the level of Hcy was higher in group B and group C, the differences were statistically significant (P＜0.05). The level of UA in group C was lower than that in group B, and the level of Hcy was higher than that in group B (P＜0.05). Conclusion: The decrease of UA and the increase of Hcy level in PD patients may reflect the degree of cognitive impairment in PD patients to a certain extent.
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