目的:探究胃癌化疗患者营养状况与化疗不良反应、生活质量相关性。方法:回顾性分析厦门大学附属第一医院2022年2月-2024年2月收治的300例胃癌化疗患者临床资料,采用营养风险筛查量表(NRS2002)对营养状况进行评估,分为营养正常组(NRS2002＜3分,n=157例)、营养风险组(NRS2002≥3分,n=143例)。比较两组营养指标、化疗不良反应、生活质量及相关性。结果:营养正常组血红蛋白(15.86±2.65)g/L、前白蛋白(256.43±9.11)mg/L、转铁蛋白(2.47±0.33)g/L、淋巴细胞计数(3.05±0.74)×10⁹/L水平均较营养风险组高,化疗不良反应分级优于营养风险组,社会功能评分(87.93±3.15)、情绪功能评分(88.45±3.24)分、角色功能评分(90.51±3.06)分、躯体功能评分(91.23±3.15)分、认知功能评分(92.03±3.29)分均较营养风险组高(P＜0.05);Pearson相关性分析显示,营养状况与化疗不良反应呈负相关性,与癌症患者生活质量量表(QLQ-30)中各维度评分呈正相关性(P＜0.05)。 结论:胃癌化疗患者营养不良发生风险较高,营养状况与化疗不良反应呈负相关,与生活质量呈正相关,临床需加以重视,采取有效干预措施,减少化疗不良反应,改善生活质量。

Objective: To explore the correlation between nutritional status, chemotherapy adverse reactions, and quality of life in gastric cancer patients undergoing chemotherapy. Methods: A total of 300 gastric cancer chemotherapy patients admitted to our hospital from February 2022 to February 2024 were selected as the research subjects. The nutritional status was evaluated using the Nutrition Risk Screening Scale (NRS2002), which was divided into a normal nutrition group (NRS2002<3, n=157 cases) and a nutrition risk group (NRS2002≥3, n=143 cases). Compare the nutritional indicators, chemotherapy adverse reactions, quality of life, and correlation between two groups. Results: The results showed that the levels of hemoglobin (15.86±2.65) g/L, prealbumin (256.43±9.11) mg/L, transferrin (2.47±0.33) g/L, and lymphocyte count (3.05±0.74) × 10⁹/L in the normal nutrition group were higher than those in the nutrition risk group. The grade of chemotherapy adverse reactions was better than that in the nutrition risk group, and the scores of social function (87.93±3.15), emotional function (88.45±3.24), role function (90.51±3.06), physical function (91.23±3.15), and cognitive function (92.03±3.29) were all higher than those in the nutrition risk group (P＜0.05); Pearson correlation analysis showed a negative correlation between nutritional status and chemotherapy adverse reactions, and a positive correlation (P＜0.05) with various dimensions of the Quality of Life Scale (QLQ-30) for cancer patients. Conclusion: Patients with gastric cancer undergoing chemotherapy have a higher risk of malnutrition, which is negatively correlated with chemotherapy adverse reactions and positively correlated with quality of life. Clinical attention should be paid to this and effective intervention measures should be taken to reduce chemotherapy adverse reactions and improve quality of life.