目的:分析成都市金牛区2017-2023年手足口病流行病学特点、病原学监测和聚集性疫情,为当地手足口病的防控策略提供科学依据。方法:用描述性流行病学研究方法,对2017-2023年成都市金牛区手足口病监测资料进行分析。结果:2017-2023年,金牛区累计报告手足口病12 960例,年报告发病率范围在64.05/10万~305.95/10万之间;除个别年份外,每年5月发病数开始增多,整体季节性流行高峰为5-7月和9-11月。男、女性报告发病数比例为1.4∶1;发病病例主要集中在0~<6岁儿童,占总发病人数90.75%;以散居儿童最多,其次为托幼儿童,共占报告病例的 92.93%。肠道病毒监测结果显示:以其他肠道病毒、CVA16、CVA6为主,分别占59.75%、15.56%、14.57%。聚集性疫情,以5-7月和9-11月为高峰期,主要在托幼机构发生,占总数的96.08%;2~5例病例事件最多,占比93.56%。结论:手足口病防控以低龄、散居儿童为重点,引起发病的优势毒株变化为关注重点。金牛区聚集疫情主要发生在托幼机构,尤其5-7月和9-11月应采取针对性措施减少疫情的发生和传播。
Objective: To analyze the epidemiological characteristics, etiological surveillance, and clustering epidemic of hand-foot-mouth disease (HFMD) in Jinniu district of Chengdu from 2017 to 2023, so as to provide basis for the prevention and control strategy of HFMD. Methods: Descriptive epidemiological research methods were used to analyze the HFMD surveillance data in Jinniu district of Chengdu, from 2017 to 2023. Results: From 2017 to 2023, a total 12 960 cases of HFMD were reported in Jinniu district, with an annual incidence rate of 64.05/100 000 to 305.95/100 000; except for a few years, the number of began to increase in May each year, with the overall seasonal epidemic peaks occurring from May to July and from September to November. The male-to-female ratio of cases was 1.4∶1; the cases were mainly concentrated in children aged 0-<6 years, accounting for 90.75% of the total number of cases; the most cases were scattered children, followed by children in kindergartens, accounting for 92.93% of the reported cases. The results of enterovirus monitoring showed that other enteroviruses, CVA16, and CVA6 were the main pathogens accounting for 59.75%, 15.56%, and 14.57%, respectively. The clustering epidemic was mainly concentrated from to July and from September to November, mainly occurring in kindergartens, accounting for 96.08% of the total; events with 2-5 cases were the most common, accounting for 93.56%. Conclusion: The prevention and control of HFMD should focus on young and scattered children, a particular emphasis on the changing dominant strains causing the disease. Outbreaks in Jinniu district mainly occurred in kindergartens, especially from May to and from September to November, during which targeted measures should be taken to reduce the occurrence and spread of the epidemic.
[1] 国家卫生健康委员会办公厅.关于印发手足口病诊疗指南(2018年版)的通知[EB/OL].(2018-05-18)[2024-08-10].http://www.nhc.gov.cn/yzygj/s3594q/201805/5db274d8697a41ea84e88eedd8bf8f63.shtml.
[2] 赵善露, 罗垲炜, 胡世雄, 等. 湖南省2008-2015年手足口病暴发疫情流行特征分析[J]. 中国热带医学, 2016, 16(9):890-892.
[3] 卫生部办公厅关于印发《手足口病聚集性和暴发疫情处置工作规范(2012版)》的通知[J].中华人民共和国卫生部公报, 2012, (6):39-41.
[4] 卫生部办公厅关于印发《手足口病预防控制指南(2009版)》的通知[J].中华人民共和国卫生部公报, 2009, (9):64.
[5] 刘雅琼, 童文彬, 马小珍, 等.2017-2021年四川省手足口病流行病学和病原学特征分析[J].现代预防医学, 2024, 51(10):1742-1747.
[6] 唐雪琴, 张量智, 孟建彤, 等.2012–2020年成都市手足口病流行病学特征及EV71疫苗接种效果分析[J]. 四川大学学报(医学版), 2022, 53(6):1074-1080.
[7] 王平平, 周璐, 吴红照, 等.浙江省金华市某县2008-2020年手足口病流行特征分析[J].上海预防医学, 2022, 34(3):210-213.
[8] 赵霞, 崔劲松, 张奕, 等.2014-2018年上海市闵行区手足口病流行特征及其与气象因子相关分析[J].上海预防医学, 2022, 34(3):219-222, 234.
[9] 蔡靖靖, 栾荣生.2017-2022年四川省法定传染病流行特征分析[J].现代预防医学, 2023, 50(9):1566-1571.
[10] 孔志芳, 杨斌, 章海斌, 等.2009-2018年浙江省宁海县手足口病流行特征及病原学分析[J].中国医院统计, 2019, 26(5):373-376, 380.
[11] 张元元, 王建醒, 袁璐, 等.山东省2017-2021年手足口病流行病学特征及病原学监测分析[J].病毒学报, 2023, 39(2):453-459.
[12] 申筑, 刘慧慧, 黄艳, 等.2010-2021年贵州省手足口病流行特征分析[J].热带病与寄生虫学, 2023, 21(4):195-198.
[13] 沈秀莲, 贾豫晨, 何继波, 等.云南省2009-2019年手足口病流行特征及时空聚集性分析[J].中国公共卫生, 2021, 37(8):1267-1272.
[14] 吴定国, 余杨, 张俊丽, 等.铜仁市2018-2022年手足口病流行病学及病原学特征分析[J].中国学校卫生, 2023, 44(12):1898-1901.
[15] 陈慧明, 刘毅, 邹于生, 等.于都县2016-2020年手足口病流行特征分析[J].安徽预防医学杂志, 2022, 28(2):148-150.
[16] 陈家凤, 张安冉, 徐红梅, 等.2017-2022年上海市浦东新区手足口病聚集性疫情特征分析[J].上海预防医学, 2024, 36(5):439-443.
[17] 张孟媛, 张瑶, 魏荣杰, 等.成都市气温对手足口病发病风险的影响研究[J].公共卫生与预防医学, 2023, 34(6):31-34.
[18] 刘雅琼, 郑红茹, 包莹, 等.四川省EV-A71疫苗接种现状与手足口病流行特征分析[J].预防医学情报杂志, 2022, 38(8):1069-1075.
[19] 刘威, 王艳梅, 江仕清, 等.一起疱疹性咽峡炎混合手足口病疫情持续传播调查分析[J].新发传染病电子杂志, 2024, 9(3):11-15.
[20] 马仲慧, 魏柯雯, 仇华, 等.2015-2022年北京市房山区手足口病和疱疹性咽峡炎疫情流行病学和病原学特征分析[J].预防医学情报杂志, 2024, 40(4):391-397, 403.
[21] 张文婷, 杜阳光, 高雪, 等.2021年江苏省徐州市手足口病和疱疹性咽峡炎病例肠道病毒病原谱分析[J].疾病监测, 2024, 39(7):863-868.