综述

泛素蛋白酶体系统在消化系统肿瘤中的研究进展*

  • 况云舒 ,
  • 罗倩 ,
  • 章雯 ,
  • 卢广涛 ,
  • 朱晓群 ,
  • 赵旭 ,
  • 孙恩涛 ,
  • 陈冰
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  • 1.皖南医学院病理教研室,安徽芜湖 241002;
    2.皖南医学院检验学院
陈 冰

收稿日期: 2023-03-06

  网络出版日期: 2024-11-19

基金资助

* 国家级大学生创新创业训练计划项目(202210368059);安徽省高校科学研究重点项目(2022AH051235)

Research on ubiquitin proteasome system in gastrointestinal cancer

  • KUANG Yunshu ,
  • LUO Qian ,
  • ZHANG Wen ,
  • LU Guangtao ,
  • ZHU Xiaoqun ,
  • ZHAO Xu ,
  • SUN Entao ,
  • CHEN Bing
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  • 1. Department of Pathology, Wannan Medical College, Wuhu 241002, China;
    2. Department of Health Inspection and Quarantine, Wannan Medical College

Received date: 2023-03-06

  Online published: 2024-11-19

摘要

泛素蛋白酶体系(UPS)是真核细胞中降解蛋白质的重要途径,它几乎参与每一个细胞过程,并在维持体内平衡中发挥重要作用。越来越多的证据表明UPS的改变与消化道恶性肿瘤有关,包括肝癌、胃癌和结直肠癌等。研究结果发现在UPS中E2、E3和DUBs的失调在肿瘤的发生和发展中起着最显著的作用,包括促进细胞增殖、迁移、侵袭、细胞周期阻滞、提高干细胞特性以及在调控相关信号通路中发挥重要作用等。在此,我们总结了近五年关于UPS在肝癌、胃癌和结直肠癌等消化系统肿瘤中的作用,强调其在肿瘤发生发展中的意义,为治疗靶点研究和抗胃肠道肿瘤药物设计提供信息。

本文引用格式

况云舒 , 罗倩 , 章雯 , 卢广涛 , 朱晓群 , 赵旭 , 孙恩涛 , 陈冰 . 泛素蛋白酶体系统在消化系统肿瘤中的研究进展*[J]. 包头医学院学报, 2024 , 40(9) : 84 -91 . DOI: 10.16833/j.cnki.jbmc.2024.09.016

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