目的:分析中性粒细胞、淋巴细胞、血小板及中性粒细胞与淋巴细胞的比值、血小板与淋巴细胞的比值与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压发生的相关性。方法:选择江门市中心医院收治的OSAHS合并高血压患者107例、单纯OSAHS患者85例、同期健康体检者45例作为研究对象,检测并比较3组研究对象血液学指标,包括中性粒细胞、淋巴细胞、血小板、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR),分析OSAHS合并高血压与血液学指标的关系。结果:对照组、单纯OSAHS组、OSAHS合并高血压组的中性粒细胞分别为(4.18±1.04)×109/L、(4.47±1.02)×109/L、(5.15±1.44)×109/L,OSAHS合并高血压组比对照组和单纯OSAHS组高(P＜0.05),单纯OSAHS组与对照组比较差异无统计学意义(P＞0.05);NLR分别为(1.94±0.48)、(2.24±0.68)、(2.51±0.733),OSAHS合并高血压组和单纯OSAHS组比对照组高,OSAHS合并高血压组比单纯OSAHS组高,差异均具有统计学意义(P＜0.05)。NLR水平在轻度高血压组及中度高血压组间比较有统计学差异(P＜0.05),在中度高血压组及重度高血压组比较,差异无统计学意义(P＞0.05)。三组间淋巴细胞、血小板、PLR的比较差异无统计学意义(P＞0.05)。结论:NLR于OSAHS合并高血压患者中明显升高,且NLR与高血压严重程度可能相关。
Objective: To investigate the correlation between neutrophil, lymphocyte, platelet and their ratio and obstructive sleep apnea hypopnea syndrome (OSAHS) with hypertension. Methods: A total of 107 patients with OSAHS complicated with hypertension, 85 patients with simple OSAHS and 45 healthy subjects in Jiangmen Central Hospital were selected as the research objects. The hematological indexes of the three groups were detected and compared, including neutrophils, lymphocytes, platelets, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The relationship between OSAHS complicated with hypertension and hematological indexes was analyzed. Results: The neutrophil count in the control group, the simple OSAHS group and OSAHS combined with hypertension group was (4.18±1.04)×109/L, (4.47±1.02)×109/L, and (5.15±1.44)×109/L, respectively. The neutrophil count in the OSAHS combined with hypertension group was higher than that in control group and simple OSAHS group (P＜0.05), but there was no significant difference between simple OSAHS group and control group (P＞0.05). The NLR level in the control group, the simple OSAHS group and OSAHS combined with hypertension group was (1.94±0.48), (2.24±0.68), (2.51±0.733),respectively. The NLR level in the OSAHS combined with hypertension group and the simple OSAHS group was higher than that in the control group, and that in the OSAHS combined with hypertension was higher than that in the simple OSAHS group, the differences was statistically significant (P＜0.05). There was statistical difference in NLR level between mild hypertension group and moderate hypertension group (P＜0.05), but there was no statistical difference between moderate hypertension group and severe hypertension group (P＞0.05). There was no significant difference in lymphocytes, platelets and PLR among the three groups (P＞0.05). Conclusion: NLR is significantly increased in OSAHS patients with hypertension, and NLR may be positively correlated with the severity of hypertension.
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