内系疾病防治专栏

电压依赖性阴离子通道与糖尿病肾脏疾病研究进展*

  • 赖连英 ,
  • 李永妍 ,
  • 杨时旭 ,
  • 王颖
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  • 海南医学院第一附属医院,海南海口 570102
王颖

收稿日期: 2023-10-19

  网络出版日期: 2024-09-03

基金资助

* 海南省自然科学基金高层次人才项目(822RC826);海南省卫生健康行业科研项目(21A200073)

Research progress of voltage-dependent anion channel and diabetic kidney disease

  • LAI Lianying ,
  • LI Yongyan ,
  • YANG Shixu ,
  • WANG Ying
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  • The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China

Received date: 2023-10-19

  Online published: 2024-09-03

摘要

电压依赖性阴离子通道(voltage dependent-anion channel, VDAC)位于线粒体外膜,是一种转运三磷酸腺苷 (adenosine triphosphate, ATP)和细胞间代谢产物的通道蛋白,对线粒体代谢及细胞生长起着重要的调节作用。最近的研究表明,VDAC在心肌病、动脉粥样硬化、高血压和糖尿病(diabetes mellitus, DM)中均有显著升高。糖尿病肾脏疾病(diabetes kidney disease, DKD)是糖尿病的主要微血管并发症,是导致终末期肾病的最常见原因,其发病机制复杂,VDAC参与其中。本文对VDAC蛋白的结构、特性、作用机制以及与DKD关系的研究进展进行综述。

本文引用格式

赖连英 , 李永妍 , 杨时旭 , 王颖 . 电压依赖性阴离子通道与糖尿病肾脏疾病研究进展*[J]. 包头医学院学报, 2024 , 40(8) : 91 -96 . DOI: 10.16833/j.cnki.jbmc.2024.08.018

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