目的:比较急、慢性布鲁菌病(简称布病)患者治疗前和治疗中外周血铁蛋白水平,评估血清铁蛋白与急、慢性布病炎性反应和布病治疗转归的关系。方法:选取急、慢性期且未接受抗生素治疗的布病患者各36例作为治疗前组;抗生素治疗10 d左右的急、慢性期布病患者各36例作为治疗中组;选取健康体检者25例作为对照组。采用酶联免疫吸附试验测定各组样本的血清铁蛋白水平,统计分析血清铁蛋白水平在各组间的差异。结果:治疗前急、慢性期和对照组血清铁蛋白水平具有明显差异(P＜0.01);急、慢性组铁蛋白水平均比对照组明显增高(P＜0.01);急性铁蛋白水平比慢性组明显升高(P＜0.01)。治疗中急、慢性期和对照组血清铁蛋白水平具有明显差异(P＜0.01);急、慢性布病组铁蛋白水平均比对照组明显增高(P＜0.01);急性布病铁蛋白水平比慢性布病明显降低(P＜0.01)。治疗中急性期、慢性期布病铁蛋白水平均比治疗前明显降低(P＜0.001)。结论: 血清铁蛋白与布鲁菌病的炎症反应程度有关,可用于监测布鲁氏菌病的炎症反应程度和评估治疗效果。

Objective: To compare the levels of peripheral blood ferritin in patients with acute and chronic brucellosis before and during treatment, and to evaluate the relationship between serum ferritin and inflammatory response of acute and chronic brucellosis and the relationship between treatment outcome of brucellosis. Methods: Thirty-six patients with acute and chronic brucellosis who did not receive antibiotic treatment were collected as the pre-treatment group. Thirty-six patients with acute and chronic brucellosis who were treated with antibiotics for about 10 days were selected as the treatment group. Twenty-five healthy subjects were selected as the control group. Serum ferritin levels in each group were measured by enzyme-linked immunosorbent assay. The differences of serum ferritin levels among groups were statistically analyzed. Results: Before treatment, the level of serum ferritin in acute and chronic phase and control group was respectively different (P＜0.01). The level of ferritin in acute and chronic groups was significantly higher than that in control group (P＜0.01). The level of ferritin in the acute group was significantly higher than that in the chronic group (P＜0.01). During the treatment, the the level of serum ferritin in the acute and chronic phases and the control group was respectively different (P＜0.01). The level of ferritin in the acute and chronic brucellosis groups was significantly higher than that in the control group (P＜0.01). The level of ferritin in acute group was significantly lower than that in chronic group (P＜0.01). The levels of ferritin in acute and chronic brucellosis were significantly lower than those before treatment (P＜0.001). Conclusion: Serum ferritin is related to the degree of inflammatory response of brucellosis, which can be used to monitor the degree of inflammatory response of brucellosis and evaluate the therapeutic effect.