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中老年男性2型糖尿病患者糖化血红蛋白控制水平与性腺激素相关性的分析*

  • 李敏 ,
  • 孙剑 ,
  • 张立飞 ,
  • 朱宏伟 ,
  • 赵媛媛 ,
  • 曹庆 ,
  • 田艳霜 ,
  • 郭小勇
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  • 1.内蒙古科技大学包头医学院第二附属医院内分泌科,内蒙古包头 014030;
    2.内蒙古科技大学包头医学院
郭小勇

收稿日期: 2023-10-08

  网络出版日期: 2024-09-03

基金资助

* 内蒙古自治区教育厅自然科学重点项目(NJZZ22060);内蒙古自治区卫健委项目(202202254);包头医学院研究生科研创新项目(bycx2023020);包头医学院秦文斌教育基金(BYJJ-QWB202221)

Analysis of correlation between glycosylated hemoglobin control level and gonadal hormone in middle-aged and elderly male patients with type 2 diabetes mellitus

  • LI Min ,
  • SUN Jian ,
  • ZHANG Lifei ,
  • ZHU Hongwei ,
  • ZHAO Yuanyuan ,
  • CAO Qing ,
  • TIAN Yanshuang ,
  • GUO Xiaoyong
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  • 1. Department of Endocrinology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014030, China;
    2. Baotou Medical College, Inner Mongolia University of Science and Technology

Received date: 2023-10-08

  Online published: 2024-09-03

摘要

目的:探讨中老年男性2型糖尿病患者糖化血红蛋白控制水平对性腺激素、体重指数、血脂、内脏脂肪面积的影响,并对影响睾酮的相关因素进行分析。方法:选择90例中老年2型糖尿病男性患者,收集30例糖化血红蛋白<7%、30例糖化血红蛋白7%~9%、30例糖化血红蛋白>9%,分别收集患者年龄、体重指数、血脂、内脏脂肪面积、性腺激素,对三组数据进行统计学分析;再根据睾酮大于中位数(>4.08 ng/mL)及小于等于中位数(≤4.08 ng/mL)分为两组,对两组之间体重指数、内脏脂肪面积、糖化血红蛋白、血脂等数据进行统计分析。结果:糖化血红蛋白水平与高密度脂蛋白、睾酮呈负相关(P<0.05),而与甘油三酯、总胆固醇、低密度脂蛋白、体重指数、内脏脂肪面积、雌二醇呈正相关(P<0.05),与促卵泡生成素、促黄体生成素、泌乳素水平无关(P>0.05)。睾酮与体重指数、内脏脂肪面积、糖化血红蛋白、甘油三酯,总胆固醇,低密度脂蛋白水平呈负相关(P<0.05),与高密度脂蛋白呈正相关(P<0.05)。Logistic回归分析显示:糖化血红蛋白水平,内脏脂肪面积、体重指数、血脂异常是睾酮减少的危险因素。结论:良好的血糖控制可有效减少男性睾酮下降,促进机体脂质代谢;较高的睾酮水平对血糖、血脂代谢亦起到积极作用;糖化血红蛋白、内脏脂肪面积、体重指数、血脂异常是睾酮减少的危险因素。

本文引用格式

李敏 , 孙剑 , 张立飞 , 朱宏伟 , 赵媛媛 , 曹庆 , 田艳霜 , 郭小勇 . 中老年男性2型糖尿病患者糖化血红蛋白控制水平与性腺激素相关性的分析*[J]. 包头医学院学报, 2024 , 40(8) : 55 -59 . DOI: 10.16833/j.cnki.jbmc.2024.08.011

Abstract

Objective: To investigate the effect of glycated hemoglobin control level on gonadal hormone, body mass index, blood lipid and visceral fat area in middle-aged and elderly male patients with type 2 diabetes mellitus, and to analyze the related factors affecting testosterone. Methods: A total of 90 middle-aged and elderly male patients with type 2 diabetes mellitus were selected and divided into good blood glucose control group (30 patients, glycosylated hemoglobin<7%), poor blood glucose control group (30 patients, glycosylated hemoglobin 7%~9%) and bad blood glucose control group (30 patients, glycosylated hemoglobin >9%), the age, body mass index, blood lipid, visceral fat area and gonadal hormone of the patients were collected, and the data of the three groups were statistically analyzed. According to testosterone greater than the median (≤4.08 ng/mL) and less than or equa to the median (<4.08 ng/mL), they were divided into two groups, and the body mass index, visceral fat area, glycosylated hemoglobin, blood lipids and other data between the two groups were statistically analyzed. Results: The level of glycosylated hemoglobin was negatively correlated with high density lipoprotein and testosterone (P<0.05), and positively correlated with triglyceride, total cholesterol, low density lipoprotein, body mass index, visceral fat area and estradiol (P<0.05), but not with follicle stimulating hormone, luteinizing hormone and prolactin (P>0.05). Testosterone was negatively correlated with body mass index, visceral fat area, glycosylated hemoglobin, triglyceride, total cholesterol and low density lipoprotein (P<0.05), and positively correlated with high density lipoprotein (P<0.05). Logistic regression analysis showed that glycosylated hemoglobin level, visceral fat area, body mass index and dyslipidemia were risk factors for testosterone reduction. Conclusion: Good blood glucose control can effectively reduce the decrease of testosterone in men, and can effectively promote the body's lipid metabolism; higher testosterone levels also play a positive role in blood glucose and lipid metabolism. Glycosylated hemoglobin, visceral fat area, body mass index, dyslipidemia are risk factors for testosterone reduction.

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