目的:分析幽门螺杆菌对血压、颈动脉硬化、长链非编码RNA(LncRNA) MALAT1、一氧化氮(NO)、皮质酮及新发心脑血管疾病的影响。方法:将既有高血压又有幽门螺杆菌感染患者分为试验组和对照组,各296例,对照组进行降压降脂处理,试验组在此基础上加抗幽门螺杆菌药,之后记录并对比两组血压以及血脂水平、颈动脉内膜厚度、心率等变化,随访2年观察二者新发心脑动脉闭塞发生比例;将32只6周龄雄性大鼠分为自发性高血压(spontaneously hypertensive rats, SHR)大鼠A、B组,正常血压(Wistar-Kyoto, WKY)大鼠C、D组,每组8只,对A和C组大鼠进行幽门螺杆菌灌服,B和D组灌0.9%NaCl,14周后取血及胃组织检测。结果:(1)幽门螺杆菌影响血压值,使SHR和WKY大鼠血压都明显升高;SHR升压程度更明显(P＜0.05)。(2)幽门螺杆菌值增大影响LncRNA MALAT1、NO、皮质酮水平(P＜0.05)。(3)幽门螺杆菌值下降后新发心脑动脉供血不足甚至堵塞等情况的比例较对照组少(P＜0.05)。结论:(1)幽门螺杆菌含量与血压值升高以及LncRNA MALAT1、皮质酮升高呈正相关,与NO负相关。(2)治疗幽门螺杆菌后血压等级程度下降、冠脉脑动脉闭塞发生占比减少。
Objective: To analyze the effects of Helicobacter pylori on blood pressure, carotid atherosclerosis, long non-coding RNA (LncRNA) MALAT1, nitric oxide (NO), corticosterone and new cardiovascular and cerebrovascular diseases. Methods: The patients with both hypertension and Helicobacter pylori infection were divided into experimental group and control group. 296 cases each.The control group was treated with antihypertensive and lipid-lowering treatment, and the experimental group was treated with anti-Helicobacter pylori drugs on this basis. Then the changes of blood pressure, blood lipid level, carotid intima thickness and heart rate were compared between the two groups. After 2 years of follow-up, the proportion of new cardiocerebral artery occlusion was observed. Thirty-two 6-week-old male rats were divided into spontaneously hypertensive rats (SHR) group A and group B, Wistar-Kyoto (WKY) rats group C and group D, with 8 rats in each group. Rats in group A and group C were given Helicobacter pylori gavage, and rats in group B and group D were given 0.9% NaCl gavage. After 14 weeks, blood and gastric tissue were taken for detection. Results: (1) Helicobacter pylori affected blood pressure, so that the blood pressure of SHR and WKY rats were significantly increased; the degree of hypertension in SHR was more obvious (P＜0.05). (2)The increase of Helicobacter pylori value affected the levels of LncRNA MALAT1, NO and corticosterone (P＜0.05). (3) The proportion of new heart and cerebral artery insufficiency or even occlusion after the decrease of Helicobacter pylori value was less than that of the control group (P＜0.05). Conclusion: (1)The content of Helicobacter pylori is positively correlated with the increase of blood pressure, LncRNA MALAT1 and corticosterone, and negatively correlated with NO. (2) After the treatment of Helicobacter pylori, it can reduce the degree of blood pressure level and the proportion of coronary cerebral artery occlusion.
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