目的: 了解包头地区不同人群他汀类药物的使用现状,并进行影响因素分析,为制定心脑血管病精准防控策略提供数据参考。方法: 2021年6月至2022年9月,采用多阶段整群随机抽样方法,抽取包头地区40岁以上常住居民,调查研究对象一般情况、心脑血管疾病认知水平及他汀使用情况,影响因素采用Logistic回归进行分析。结果: 共登记有效调查对象2 100例,年龄为(58.7±11.0)岁(40～94)岁,男性占45.1%(n=948)。其中既往有心脑血管疾病(CVD)史占14.2%(298例),无CVD有危险因素人群49.5%(1 040例),正常人群36.3%(762例)。包头地区报告使用他汀类药物比例14.8%,三组人群分别为46.3%、14.2%、3.1%。多因素分析结果显示,CVD组中,女性患者服用他汀类药物可能性小;高龄、患有高血压、糖尿病且CVD认知水平高则与他汀使用率呈正相关。CVD危险因素组多因素分析结果提示,高龄、CVD认知水平高,他汀类药物使用可能性大,农村、吸烟、肥胖人群可能性小。正常组人群服用他汀原因占比:自觉应服用＞亲友介绍＞广告媒体宣传＞医生处方。结论: 内蒙古包头地区人群在心脑血管病二级预防、一级预防中他汀类药物使用不规范,不同亚组人群中差异较大,且存在正常人群过度用药情况。

Objective: To investigate the application status and influencing factors of statins in different populations in Baotou area, so as to provide data reference for making accurate prevention and control strategies to cardiovascular diseases (CVD). Methods: From June 2021 to September 2022, residents over 40 years old in Baotou area were randomly selected by multi-stage cluster and random sampling. The general information, cognition level of cardiovascular and cerebrovascular disease, and application of statins of the research objects were collected and registered by questionnaire. The participants were divided into the CVD group, CVD risk-factor group, and normal group. Logistic regression analysis was used to evaluate the CVD influencing factors in each group. Results: A total of 2 100 valid respondents were registered. The averase age was (58.7±11.0) years,ranging from 40 to 94, male accounted for 45.1% (n=948). Among them, 14.2% (298) had a history of cardiovascular and cerebrovascular disease (CVD), 49.5% (1 040) had no CVD but risk factors, and 36.3% (762) had no CVD and risk factors. The proportion of statins use was 14.8% in Baotou area, with 46.3%, 14.2% and 3.1% in the three groups respectively. Multivariate analysis showed that women in the CVD group were less likely to take statins. Advanced age, hypertension, diabetes and high CVD awareness were positively associated with application of statins. Multivariate analysis of the CVD risk-factor group suggest that people with older age and higher cognition level of CVD were more likely to use statin, while rural, smoking and obesity population were less likely to take stains. The proportion of reasons for taking statins in the normal group were self-awareness of taking statins＞introduction of relatives and friends＞advertising and media publicity＞doctor’s prescription. Conclusion: In Baotou area, the application of statins in the secondary prevention and primary prevention of cardiovascular and cerebrovascular diseases is not standard. There were great differences among different subgroups of population, and there are overmedication in the normal population.