目的: 通过检测正常健康女性和卵巢癌女性的血清人附睾蛋白4(HE4)、糖蛋白抗原153(CA153)含量,发现其对卵巢癌的诊断价值。方法: 选取2020年6月至2021年9月南京市妇幼保健院健康体检女性81例和诊断为卵巢癌的女性81例分别进行血清HE4、CA153检测,将检测结果进行统计并比较差异。结果: 卵巢癌组的血清HE4为(47.94±24.62) pmol/L、血清CA153为(17.44±34.99) U/mL,正常健康女性组的血清HE4为(41.86±8.21) pmol/L、血清CA153为(9.39±5.05) U/mL,卵巢癌组女性的血清HE4和CA153水平均高于健康女性组,且差异有统计学意义。结论: 血清HE4和CA153有助于卵巢癌的诊断。
Objective: To explore the diagnostic value of human epididymal protein 4 (HE4) and carbohydrate antigen 153 (CA153) in ovarian cancer by detecting their contents in normal healthy women and women with ovarian cancer. Methods: A total of 81 healthy females and 81 females diagnosed with ovarian cancer were selected from Nanjing Maternity and Child Health Care Hospital from June 2020 to September 2021 for serum HE4 and CA153 detection. The detected results were statistically analyzed with SPSS software and the differences were compared. Results: The serum HE4 and CA153 in the ovarian cancer group were (47.94±24.62) pmol/L and (17.44±34.99) U/mL, and the serum HE4 and CA153 in the healthy women group were (41.86±8.21) pmol/L and (9.39±5.05) U/mL. The serum levels of HE4 and CA153 in women with ovarian cancer were higher than those in healthy women, and the differences were statistically significant. Conclusion: Serum HE4 and CA153 contribute to the diagnosis of ovarian cancer.
[1] 隋磊, 姚勤. 卵巢癌肿瘤微环境中长链非编码RNA的研究进展[J]. 现代肿瘤医学, 2022, 30(15): 2851-2854.
[2] 钟剑锋, 钟莉莉, 于双. LncRNA与肿瘤关系的研究进展[J]. 中国实验诊断学, 2022, 26(6): 930-933.
[3] 曾艳, 祝凤翠, 宋化雨, 等. 妇科影像报告-数据系统、简单法则风险预测对卵巢癌的诊断价值[J]. 中国优生与遗传杂志, 2022, 30(6): 1024-1027.
[4] 严慧, 张云姣, 王红岗. 国际卵巢肿瘤研究组简单法则与妇科超声影像报告和数据系统在妇科卵巢肿瘤良恶性中的诊断价值[J]. 中国妇幼保健, 2022, 37(10): 1902-1905.
[5] 王亚萍, 余军辉, 王凯, 等. 卵巢组织中蛋白激酶CK2β表达与卵巢癌病理特征的关系[J]. 中国妇幼保健, 2022, 37(11): 2080-2084.
[6] 王余娜, 高显舜, 曾帮智, 等. MSCT联合血清癌胚抗原、糖类抗原125和糖类抗原19-9对女性卵巢癌的诊断价值[J]. 中国CT和MRI杂志, 2022, 20(6): 139-141.
[7] 周云, 于爱军, 吴宇辰, 等. 血清人附睾蛋白4水平及ROMA指数对CA125升高卵巢良恶性肿瘤的鉴别诊断价值[J]. 浙江医学, 2022, 44(11): 1160-1164.
[8] 栾利昆, 代佑果, 杨昌龙, 等. 不同AFP表达状态胃癌患者血清CEA水平差异及其临床意义分析[J]. 中国临床新医学, 2022, 15(6): 517-522.
[9] 高洁, 张伦军, 彭珂, 等. 血清肿瘤标志物CEA、CYFRA21-1、SCCAg、NSE、ProGRP在不同病理分型肺癌诊断中的应用价值[J]. 南方医科大学学报, 2022, 42(6): 886-891.
[10] 杜炜玮, 段铮, 胡斌. 联合血清人附睾分泌蛋白4、血管内皮细胞生长因子、白细胞分化抗原147检测在肺癌诊断及淋巴结转移监测中的价值[J]. 实用医院临床杂志, 2022, 19(3): 93-96.
[11] Kant K, Tomar AK, Sharma P, et al. Human epididymis protein 4 quantification and interaction network analysis in seminal plasma[J]. Protein Pept Lett, 2019, 26(6): 458-465.
[12] Li LM, Zhu YX, Zong Y, et al. Human epididymis protein 4 in endometrial cancer: A meta-analysis[J]. Clin Chim Acta, 2018, 482: 215-223.
[13] 杨海明, 王克义, 卓广超, 等. 人附睾蛋白4、糖类抗原125的联合检测和ROMA在卵巢癌鉴别诊断中的价值[J]. 中国卫生检验杂志, 2022, 32(10): 1166-1169, 1174.
[14] 段金霞, 芦翼飞, 范暖东, 等. TCT联合CEA、CA125、CA153检测对宫颈癌的诊断价值[J]. 实用癌症杂志, 2021, 36(12): 2054-2057.
[15] 刘文旺, 李岩, 郑丽平, 等. 胃泌素释放肽前体联合胸腔积液中CA199、CA125、 CA153对肺癌的诊断价值[J]. 国际检验医学杂志, 2022, 43(12): 1504-1507.
[16] Li XL, Xu Y, Zhang LJ. Serum CA153 as biomarker for cancer and noncancer diseases[J]. Prog Mol Biol Transl Sci, 2019, 162: 265-276.
