目的: 探究胃炎患者中白念珠菌、热带念珠菌、克柔念珠菌等念珠菌属的流行情况及感染危险因素。方法: 用调查问卷收集患者相关资料,无菌操作下收集胃炎患者消化道的黏膜标本以及胃液,进行分离鉴定,以此来探究胃炎患者中念珠菌的定植和(或)感染情况。结果: 共收集57例胃炎患者标本,其中有2例人口学特征及临床信息缺失。55例患者中,幽门螺杆菌(Hp)阳性患者25例(45.45 %),Hp阴性30例(54.55 %);临床诊断为萎缩性胃炎的患者15例(27.27 %),非萎缩性胃炎患者33例(60.00 %)。胃炎患者上消化道的主要念珠菌菌种为白念珠菌和克柔念珠菌,其次为热带念珠菌,光滑念珠菌比例较低;在下消化道样本中,主要的念珠属为克柔念珠菌,其次为热带念珠菌,白念珠菌。部分胃炎患者出现念珠菌的混合阳性。 结论: 胃炎患者上下消化道定值的菌株不同;消化道念珠菌阳性率与年龄、性别、胃炎类型无显著相关性(P＞0.05)。Hp感染对于胃炎患者的念珠菌感染来说可能是一个危险因素。
Objective: To investigate the prevalence and risk factors of Candida albicans, Candida tropicalis and Candida krusei in patients with gastritis. Methods: Relevant data of patients were collected by questionnaires, and mucosal samples and gastric juices of digestive tract of gastritis patients were collected under aseptic operation for isolation and identification, so as to explore the colonization and/or infection of candida in gastritis patients. Results: A total of 57 patients with gastritis were collected, including 2 patients with missing demographic characteristics and clinical information. Among the 55 patients, 25 (45.45 %) were HP-positive and 30 (54.55 %) were HP-negative. There were 15 patients (27.27 %) with atrophic gastritis and 33 patients (60.00 %) with non-atrophic gastritis. The main candida species in the upper digestive tract of gastritis patients were Candida albicans and Candida chrysalis, followed by Candida tropicalis, and the proportion of Candida glabrata was relatively low. In the samples of the lower digestive tract, the main candida genus was Candida Chrysalis, followed by Candida tropicalis and Candida albicans. Some patients with gastritis showed mixed positive candida. Conclusion: The strains of upper and lower digestive tract were different in patients with gastritis. The positive rate of candida was not significantly correlated with age, sex or type of gastritis (P＞0.05). Hp infection may be a risk factor for candida infection in gastritis patients.
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