目的:采用数据挖掘技术研究蒙医药治疗布鲁氏菌病的用药规律,为临床治疗提供参考。方法:采集通辽市蒙医医院布鲁氏菌病科临床常用药物数据及检索中国知网、维普、万方三大中文数据库中自建库起所有蒙药治疗布病的相关文献,全面系统地整理治疗布病的处方,并通过SPSS 25以及IBM SPSS Modeler 18等分析软件对蒙药用药的药物成分进行整理归类以及对频次、关联规则等分析,来研究蒙医药治疗布鲁氏菌病的用药规律。结果:治疗布鲁氏菌病常用的蒙药单药中高频次用药为栀子、木香、川楝子、豆蔻、诃子和红花;药性主要以温、寒为主;药味主要以甘、辛和苦为主;脏腑归类分析主要集中在脾、胃、肝;核心用药为栀子、川楝子、红花、豆蔻、木香和诃子。结论:蒙医药治疗布鲁氏菌病时从整体杀粘、解毒,调理三根,遵从的总原则是以益黑白脉运行,僵润筋骨,其与现代医学杀菌、抗炎、免疫调节等治疗原则相吻合,可为蒙医药治疗布鲁氏菌病机制研究提供理论依据。
Objective: To explore the medication rules of Mongolian medicine in the treatment of brucellosis based on data mining. Methods: The data of commonly used clinical drugs in the Department of Brucellosis of Tongliao Mongolian Medical Hospital were collected and relevant literatures on treating brucellosis with Mongolian medicine in the database of CNKI, CQVIP and WANFANG DATA from their building to now were retrieved.The prescriptions for the treatment of brucellosis were sorted out comprehensively and systematically, and the drug composition, frequency, compatibility rules of Mongolian medicine were analyzed using SPSS 25 and IBM SPSS Modeler 18. Results: In the treatment of brucellosis, the most frequently used single Mongolian medicines are gardenia, Radix Aucklandiae, Fructus Toosendan, Fructus amomi rotundus and fructus chebulae. The main properties of those medicines are warm and cold, with the main flavors of sweet, hard and bitter. The classification and analysis of viscera mainly focused on spleen, stomach and liver. The core drugs are Fructus Gardenia, Fructus Toosendan, Saffiower, Fructus amomi rotundus, cardamom, Chopper. Conclusion: In the treatment of brucellosis with Mongolian medicine, the three principles of overall stickkilling, detoxification and conditioning should be followed. The general principle is to run the black and white pulse, smooth the stiffness of muscles and bones, which is consistent with the therapeutic principles of sterilization, anti-inflammatory and immune regulation in modern medicine. Therefore, this study provides theoretical basis for the research on the mechanism of treating brucellosis with Mongolian medicine
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