目的:探究原发性肠套叠与食物过敏原特异性IgE、食物特异性IgG及血管活性肠肽的相关性。方法:选取包头市第四医院2021年10月至2022年5月入院的肠套叠患儿35例为肠套叠组,并选取同期入院的非肠道疾病患儿35例为非肠道疾病组,比较两组患儿7种食物过敏原特异性IgE抗体、食物特异性IgG抗体及血清血管活性肠肽水平。结果:肠套叠组患儿食物过敏原特异性IgE总阳性率为40.00 %,非肠道疾病组患儿食物过敏原特异性IgG总阳性率为28.57 %,两组各项食物过敏原特异性IgE阳性率及总阳性率均无统计学意义(P＞0.05);肠套叠组患儿食物特异性IgG总阳性率为88.57 %,非肠道疾病组患儿食物过敏原特异性IgE总阳性率为62.86 %,且肠套叠组总阳性率高于非肠道疾病组,差异具有统计学意义(P＜0.05),但两组各类食物特异性IgG阳性率差异无统计学意义(P＞0.05)。肠套叠组血管活性肠肽水平低于非肠道疾病组患儿,差异具有统计学意义(P＜0.05);食物特异性IgG阳性患儿与阴性患儿血清血管活性肠肽水平差异具有统计学意义(P＜0.05),食物特异性IgG与血管活性肠肽之间呈负相关关系(P＜0.05)。结论:食物过敏原特异性IgE与原发性肠套叠的发生未见明显相关性,而食物特异性IgG与原发性肠套叠的发生具有相关性。肠套叠患儿血清中血管活性肠肽的水平发生改变,提示血管活性肠肽的水平改变与原发性肠套叠的发生有关,且食物特异性IgG可能通过调节血管活性肠肽水平进而影响肠道功能,最终导致原发性肠套叠的发生。

Objective: To investigate the correlation between primary intussusception and food allergen-specific IgE, food-specific IgG and vasoactive intestinal peptide. Methods: A total of 35 children with intussusception admitted to the Fourth Hospital of Baotou from October 2021 to May 2022 were selected into the experimental group, and 35 children with no intestinal diseases at the same period were selected into the control group. The levels of 7 food allergen-specific IgE antibodies, food-specific IgG antibodies and serum vasoactive intestinal peptide of children between the two groups were compared. Results: The total positive rate of food allergen-specific IgE in children of the experimental group was 40.00 % and 28.57 % in the control group, and the differences in positive rate and total positive rate of food allergen-specific IgE of the two groups were not statistically significant (P＞0.05). The total positive rate of food-specific IgG was 88.57 % in the children of the experimental group and 62.86 % in the control group, and the difference was statistically significant (P＜0.05), but the difference in the positive rate of various types of food-specific IgG in the two groups was not statistically significant (P＞0.05). The level of vasoactive intestinal set was lower in the experimental group than that in the control group, and the difference was statistically significant (P＜0.05). The difference in serum vasoactive intestinal peptide levels between food-specific IgG-positive and negative children was statistically significant (P＜0.05), and there was a negative correlation between food-specific IgG and vasoactive intestinal peptide (P＜0.05). Conclusions: No significant correlation was seen between food allergen-specific IgE and the occurrence of primary intussusception, while food-specific IgG was correlated with the occurrence of primary intussusception. The changed levels of vasoactive intestinal peptides in the serum of children with intussusception suggest that the level of vasoactive intestinal peptide is related to the occurrence of primary intussusception, and that food-specific IgG may affect intestinal function by regulating the levels of vasoactive intestinal peptides, which ultimately lead to the occurrence of primary intussusception.