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Wnt/β-catenin信号通路在糖尿病肾病中的发病机制研究进展

  • 陈欣楠 ,
  • 李增艳
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  • 1.包头医学院,内蒙古包头 014040;
    2.包头医学院第一附属医院

收稿日期: 2023-04-21

  网络出版日期: 2023-09-22

Review on the pathogenesis of Wnt/β-catenin signaling pathway in diabetic nephropathy

  • CHEN Xinnan ,
  • LI Zengyan
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  • 1. Baotou Medical College, Baotou 014040, China;
    2. The First Affiliated Hospital of Baotou Medical College

Received date: 2023-04-21

  Online published: 2023-09-22

摘要

Wnt蛋白家族属于一类具有高度保守半胱氨酸残基的分泌性脂质修饰糖蛋白,其通路是一组高度保守的信号转导通路,能够介导多种生理和病理过程,如参与调控细胞增殖、分化、凋亡、免疫与应激、炎症和纤维化。目前认为Wnt信号通路包括三个分支:经典Wnt信号通路,即Wnt/β-Catenin信号通路;Wnt/PCP通路;Wnt/Ca2+通路。Wnt/β-catenin信号途径在心、肝、肺、肾等器官纤维化等病理生理过程中均发挥了重要作用。越来越多的证据表明,Wnt/β-catenin信号通路在糖尿病肾病(diabetic nephropathy, DN)的进展中意义重大。本文就Wnt/β-catenin在系膜细胞凋亡、上皮间充质转变(epithelial mesenchymal transition, EMT)、DN条件下足细胞功能障碍、小管EMT和肾纤维化中的作用进行综述。此外,还介绍了这一过程所涉及的分子机制。这一信息为Wnt/β-catenin保护肾脏损伤和延缓DN进展提供了一个新的分子靶点。

本文引用格式

陈欣楠 , 李增艳 . Wnt/β-catenin信号通路在糖尿病肾病中的发病机制研究进展[J]. 包头医学院学报, 2023 , 39(9) : 91 -96 . DOI: 10.16833/j.cnki.jbmc.2023.09.018

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