目的:探讨2型糖尿病(diabetes mellitus type 2, T2DM)合并脑血管病(cerebral vascular disease, CVD)的相关因素及诱发二者发病的危险因素。方法:选取本院2020年1月-2020年12月住院治疗的218例患者,其中单纯2型糖尿病患者118例,标记为T2DM组;2型糖尿病合并脑血管病患者100例,标记为T2DM+CVD组,比较两组之间临床资料以及生化指标的差异。所有数据采用SAS统计学分析。结果:T2DM组与T2DM+CVD组在年龄、性别、身体质量指数(body mass index, BMI)、血压、糖化血红蛋白(glycated hemoglobin glycosylated hemoglobin, HbA1c)、低密度脂蛋白(low density lipoprotein-cholesterol, LDL-C)、胱抑素C(cystatin C, CYSC)水平间差异有统计学意义(P＜0.05),而病程、烟酒史、空腹血糖(fasting blood glucose, FBG)、餐后2 h血糖(postprandial blood glucose, PBG)、总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)、高密度脂蛋白(high density lipoprotein-cholesterol, HDL-C)水平两组间差异无统计学意义(P＞0.05)。年龄、性别、血压、LDL-C、CYSC与T2DM及CVD的发病呈正相关(P＜0.05),而Hb1AC与T2DM合并CVD的发病呈负相关(P＜0.05)。年龄及LDL-C可能是T2DM合并CVD的危险因素,HbA1c可能是T2DM合并CVD的保护因素,而性别、BMI、血压、CYSC可能不是T2DM合并CVD的独立相关因素。结论:年龄、性别、BMI、血压、Hb1Ac、LDL-C、CYSC均与T2DM及CVD的发病相关,监控相关生化指标可以对T2DM合并CVD患者采取积极干预性措施加以预防。
Objective: To investigate the related factors of type 2 diabetes mellitus (T2DM) with cerebral vascular disease (CVD) and the risk factors inducing the occurrence of the two diseases. Methods: A total of 218 patients with type 2 diabetes mellitus in our hospital from January 2020 to December 2020 were selected, including 118patients with simple type 2 diabetes mellitus (T2DM group) and 100 patients with type 2 diabetes mellitus complicated with cerebrovascular disease (T2DM+CVD group). The differences of clinical data between the two groups were compared and the data were analyzed by SAS. Results: There were statistically significant differences in age, gender, body mass index (BMI), blood pressure, glycosylated hemoglobin (HbA1c), low density lipoprotein-cholesterol (LDL-C), and cystatin C (CYSC) levels between T2DM group and T2DM+CVD group (P＜0.05), but there was no significant difference in the course of disease, history of tobacco and alcohol, fasting blood glucose (FBG), postprandial 2 h blood glucose (PBG), total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) levels between the two groups(P >0.05). Age, sex, BMI, blood pressure, LDL-C, CYSC were positively correlated with the incidence of T2DM and CVD(r ＞0,P＜0.05), while Hb1Ac was negatively correlated with the incidence of T2DM and CVD(r ＜0,P＜0.05). Age and LDL-C might be the risk factors of T2DM with CVD, HbA1c might be the protective factors of T2DM with CVD, while sex, BMI, blood pressure and CYSC might not be independent related factors of T2DM with CVD. Conclusion: Age, sex, BMI, blood pressure, Hb1Ac, LDL-C and CYSC are all related to the incidence of T2DM and CVD. Monitoring the relevant biochemical indexes can actively take intervention measures to prevent T2DM complicated with CVD.
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