目的:研究外周血中性粒细胞CD64指数(nCD64IND)、单核细胞CD14指数(mCD14IND)和白细胞介素6(IL-6)水平在成人肺部感染中的诊断价值。方法:选择2020年12月至2021年2月在福建医科大学附属漳州市医院呼吸科住院的成人肺部感染患者63例作为研究组,47例健康成人作为对照组;应用流式细胞术测定外周血中nCD64IND、mCD14IND和IL-6水平;用Pearson法分析三者与肺部感染常用指标CRP、PCT的相关性;通过绘制ROC曲线评估三者对肺部感染诊断的敏感度和特异度。结果:成人肺部感染患者外周血nCD64IND、mCD14IND和IL-6水平明显高于健康对照组(均P＜0.05);相关性分析显示,患者外周血nCD64IND、IL-6水平与CRP呈正相关,mCD14IND与CRP呈负相关,三者与PCT相关性均不显著;ROC曲线分析显示,nCD64IND、mCD14IND、IL-6水平在肺部感染诊断中的敏感度分别是81 %、58.7 %、84.1 %,特异度分别是89.4 %、78.7 %、89.4 %。结论:外周血nCD64IND、mCD14IND和IL-6水平测定对肺部感染具有一定诊断价值。

Objective: To investigate the diagnostic value of peripheral blood neutrophil CD64 index (nCD64IND), monocyte CD14 index (mCD14IND) and interleukin 6 (IL-6) levels in adult pulmonary infection. Methods: A total of 63 adult patients with pulmonary infection hospitalized from December 2020 to February 2021 were selected as the study group and 47 healthy adults as the control group. The levels of nCD64IND, mCD14IND and IL-6 in peripheral blood were determined by flow cytometry. Pearson's method was used to analyze the correlation between the three indices and the common indicators of pulmonary infection, such as CRP and PCT. The ROC curve was drawn to evaluate the sensitivity and specificity of the three indices in the diagnosis of pulmonary infection. Results: The levels of nCD64IND, mCD14IND and IL-6 in peripheral blood of adult patients with pulmonary infection were significantly higher than those of healthy control group (all P＜0.05). Correlation analysis showed that the levels of nCD64IND and IL-6 in peripheral blood of patients were positively correlated with CRP, mCD14IND was negatively correlated with CRP, and the three indices were not significantly correlated with PCT. ROC curve analysis showed that the sensitivity of nCD64IND, mCD14IND and IL-6 levels in the diagnosis of lung infection was 81 %, 58.7 % and 84.1 %, respectively, and the specificity was 89.4 %, 78.7 % and 89.4 %, respectively. Conclusion: The determination of nCD64IND, mCD14IND and IL-6 in peripheral blood has certain diagnostic value for pulmonary infection.