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三氧化二砷在白血病治疗中的研究进展*

  • 任富玉 ,
  • 马强 ,
  • 刘治 ,
  • 苏燕
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  • 内蒙古科技大学包头医学院生物化学与分子生物学教研室,内蒙古包头 014040

收稿日期: 2023-04-18

  网络出版日期: 2023-06-30

基金资助

*第十批草原英才创新团队项目;2021年度自治区留学人员创新创业启动支持计划;包头医学院花蕾计划项目

The research progress of arsenic trioxide in the treatment of leukemia

  • REN Fuyu ,
  • MA Qiang ,
  • LIU Zhi ,
  • SU Yan
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  • Department of Biochemistry and Molecular Biology,Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040,China

Received date: 2023-04-18

  Online published: 2023-06-30

摘要

白血病是一类起源于造血系统并具有高度异质性的恶性克隆性疾病。三氧化二砷(arsenic trioxide, ATO, As2O3)是治疗急性早幼粒细胞性白血病(acute promyelocytic leukemia, APL)和其他类型白血病的重要药物。ATO治疗APL效果最为显著,可通过多种机制发挥作用,包括诱导细胞凋亡和自噬、抑制细胞生长等,同时ATO联合其他药物治疗白血病也取得了很大的研究进展。然而,虽然ATO治疗白血病有很好的疗效,但其具有全身细胞毒性作用,近年来研究学者致力于采用纳米技术靶向递送ATO和其他药物以降低其毒性作用的研究已取得一定的成果。

本文引用格式

任富玉 , 马强 , 刘治 , 苏燕 . 三氧化二砷在白血病治疗中的研究进展*[J]. 包头医学院学报, 2023 , 39(6) : 92 -96 . DOI: 10.16833/j.cnki.jbmc.2023.06.019

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