目的:观察蒙医联合中西医的方法治疗布鲁氏菌病患者的临床疗效,分析评价该联合疗法的治疗效果,为布鲁氏菌病诊疗方案的制定和治疗方法的增进提供新的思路。方法:观察通辽市蒙医研究所布病科2021年3月-2021年5月确诊为布鲁氏菌病的113例患者的治疗效果、治疗期间出现的不良反应以及治疗的总有效率,依据国家试行标准中的疗效判定指标分析疗效。结果:113例好转率31.0 %,基本治愈率37.2 %,治愈率27.4 %,总有效率为95.6 %,治疗期间患者出现肝功能异常者6例,胃肠道不适19例,经治疗后均有一定程度的好转,其余患者经治疗效果显著。结论:蒙医联合中西医的治疗方法治疗布鲁氏菌病疗效显著,具有不良反应小、复发率低、治愈率高、经济适用等优点,值得更深一步探索和推广。
关键词:
布鲁氏菌病; 蒙医; 中医; 西医; 疗效
Objective: To study the clinical efficacy of Mongolian medicine combined with TCM and western medicine in the treatment of patients with brucellosis, so as to provide new ideas for the diagnosis and treatment on brucellosis. Methods: A total of 113 patients diagnosed with brucellosis in the Brucellosis Department of the Institute of Mongolian Medicine of Tongliao City from March 2021 to May 2021 were selected as the research objects. Curative effect, adverse reactions during treatment and the total effective rate were observed and analyzed. The curative effect was evaluated based on the effectiveness indicators from the National Trial Standard. Results: In this study, the recovery rate was 30.0 %, the basic cure rate was 37.2 %, the cure rate was 27.4 %, and the total effective rate was 95.6 %. Abnormal liver function and gastrointestinal reactions were the main adverse reactions of patients during the treatment , which were all improved to a certain extent after treatment. The other patients were also obviously improved after treatment. Conclusion: Treating patients with Brucellosis using Mongolian medicine combined with TCM and Western medicine could achieve remarkable curative effect, with the advantages of small toxic and side effects, low recurrence rate, high cure rate and economic efficiency, which is worthy of further exploration and promotion.
[1] Ran XH, Chen XH, Wang MM, et al. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis[J].BMC Vet Res, 2018, 14(1): 393.
[2] 王艳春, 黄海林, 张青, 等. 儿童布氏杆菌病14例临床分析[J].中国实用医刊, 2019(24): 20-22.
[3] WS 269-2007布鲁氏菌病诊断标准[M].北京: 人民卫生出版社, 2008: 1.
[4] 德胜, 宝喜春. 蒙药治疗重症布病优势分析[J].中国民族医药杂志, 2021, 27(5): 26-27, 55.
[5] 陈秀红. 蒙医温针结合熏蒸治疗LDH所致下肢白脉病的临床研究[D].北京中医药大学, 2020.
[6] 白英歌, 鲍劲松. 蒙药治疗老年性布病81例疗效观察[J].中国民族医药杂志, 2016, 22(4): 27.
[7] Solís García del Pozo J, Solera J. Systematic review and meta-analysis of randomized clinical trials in the treatment of human brucellosis[J].PLoS One, 2012, 7(2): e32090.
[8] Furesz S. Chemical and biological properties of rifampicin.Antibiot Chemother[J].Antibiot Chemother, 1970, 16: 316-351.
[9] Girling DJ, Hitze KL. Adverse reactions to rifampicin[J].Bull World Health Organ, 1979, 57(1): 45-49.
[10] 董茹婷, 于莉莉. 利福喷丁与利福平在肺结核治疗中的药效对比[J].中西医结合心血管病电子杂志, 2020, 8(34): 51-52.
[11] Zeng H, Wang YM, Sun XD, et al. Status and influencing factors of farmers' private investment in the prevention and control of sheep brucellosis in China: A cross-sectional study[J].PLoS Negl Trop Dis, 2019, 13(3): e0007285.
[12] 李萌, 柏兆方, 章从恩, 等. 复方益肝灵胶囊预防抗结核药物性肝损伤的血清学指标Meta分析[J].世界中医药, 2021, 16(13): 1977-1981.
[13] 曾鹏, 周航. 网络药理学“异病-异方”关键成分筛选同质化现象思考[J].中国实验方剂学杂志, 2022, 28(18): 177-191.
[14] Zhao L, Hartung T. Metabonomics and toxicology[J].Methods Mol Biol, 2015, 1277: 209-231.