代谢重编程是促进肿瘤进展的重要因素之一。多项研究表明,对于代谢重编程的重要靶点进行干预,可以抑制肿瘤进展和预后。相比糖代谢在肿瘤中的重编程现象,脂肪酸代谢在肿瘤中的重编程现象目前少有报道。肉碱棕榈酰转移酶家族(carnitine palmitoyltransferase fattyacids,CPT)通过介导长链脂肪酸(Long-chain fattyacids,LCFA)穿过线粒体双层膜,进行β-氧化为细胞提供能量,因此它们是脂肪酸分解代谢的“守门员”。其中肉碱棕榈酰转移酶1C(carnitine palmitoyltransferase fattyacids1c,CPT1C)是该家族中最近发现的成员,在脑组织与肿瘤中特异性表达,因此在肿瘤研究领域也备受关注。目前研究揭示CPT1C影响肿瘤的发生和发展,在低糖、低氧、衰老等代谢应激状态下表现出对癌细胞的保护作用。文章主要通过描述CPT1C的分子结构与生物学功能以及在癌细胞中的作用及上游调控机制,探讨其作为抗癌细胞药物新靶点的研究前景。
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