综述

无创胎儿DNA检测假阳性对产前诊断的影响分析*

  • 刘小霞 ,
  • 王杰 ,
  • 武丽琼 ,
  • 郭志远 ,
  • 张丽春 ,
  • 王晓华 ,
  • 贾跃旗
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  • 1.内蒙古科技大学包头医学院,内蒙古包头 014040;
    2.内蒙古自治区妇幼保健院遗传优生科

收稿日期: 2022-07-14

  网络出版日期: 2023-03-07

基金资助

*内蒙古自然科学基金(2019MS08006)

Effect of false positive in non-invasive DNA detection on prenatal diagnosis

  • LIU Xiaoxia ,
  • WANG Jie ,
  • WU Liqiong ,
  • GUO Zhiyuan ,
  • ZHANG Lichun ,
  • WANG Xiaohua ,
  • JIA Yueqi
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  • 1. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China;
    2. Genetic Eugenic Department of Inner Mongolia Maternity and Child Health Care Hospital

Received date: 2022-07-14

  Online published: 2023-03-07

摘要

无创胎儿DNA检测(non-invasive prenatal testing,NIPT)假阳性是导致增加额外的产前诊断和孕妇依从性降低的重要原因,还可能带来非必要的引产。本文就无创胎儿DNA检测假阳性对产前诊断的影响分析进行综述,通过分析NIPT假阳性的原因,在临床应用中结合不同孕妇的个体情况,为个体化、规范化的产前诊断提供指导和理论依据。

本文引用格式

刘小霞 , 王杰 , 武丽琼 , 郭志远 , 张丽春 , 王晓华 , 贾跃旗 . 无创胎儿DNA检测假阳性对产前诊断的影响分析*[J]. 包头医学院学报, 2023 , 39(1) : 91 -96 . DOI: 10.16833/j.cnki.jbmc.2023.01.017

Abstract

False positive non-invasive DNA testing (NIPT) is an important cause of additional prenatal diagnosis and decreased compliance of pregnant women, and can also lead to the unnecessary induction of labor. This paper reviews the analysis of the influence of false positive non-invasive fetal DNA test on prenatal diagnosis, and provides guidance and theoretical basis for individualized and standardized prenatal diagnosis by analyzing the causes of false positive detection of NIPT and combining the individual situation of different pregnant women in clinical application.

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