上皮剪接调节蛋白1(epithelial splicing regulatory protein1,ESRP1)是近年发现的RNA结合蛋白,具有选择性剪接前体mRNA的作用,能够在转录水平调节基因的表达,进而影响基因转录过程。从分子生物学和基因学角度深入研究后发现,ESRP1在多种不同部位的肿瘤中表达情况不一,可能通过信号通路的调控致使恶性肿瘤浸润性、迁移性增强并影响患者预后。ESRP1对肿瘤的起源、进展、转移及预后判断等多方面具有重大意义,本文将围绕ESRP1与恶性肿瘤相关性的研究展开综述,为ESRP1相关的肿瘤诊疗扩展思路。
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