目的: 探讨食管癌精确放疗所致放射性肺炎的相关影响因素。方法: 回顾性分析放疗科110例食管癌患者精确放疗的临床资料,观察放射性肺炎的发生情况,并对相关因素进行统计分析。结果: 110例患者中肿瘤完全缓解10例,占9.09 %;部分缓解66例,占60.00 %;病情稳定26例,占23.64 %;肿瘤进展8例,占7.27 %;临床获益率为69.09 %。110例患者中22例出现了放射性肺炎,发生率为20.0 %。单因素分析显示卡氏评分(Karnofsky performance score,KPS)、慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、同步放疗化疗、肿瘤靶区(gross tumor volume,GTV)处方剂量、肺V20、肺的平均照射剂量及放疗计划靶区(planning target volume,PTV)与放射性肺炎相关。结论: KPS、同步放疗化疗、COPD、肺V20、肺的平均照射剂量、GTV处方剂量、PTV是食管癌放疗所致放射性肺炎的主要危险因素。
Objective: To evaluate the correlative factors of radiation pneumonitis ( RP) induced by radiotherapy for patients with esophageal cancer who were treated with precise radiotherapy.Methods: Clinical data of 110 patients with esophageal cancer who were treated with precise radiotherapy were retrospectively analyzed, with the incidence of radiation pneumonitis observed and correlative factors analyzed.Results: Of the 110 cases, 10 cases got complete remission(CR), accounting for 9.09 %, 66 cases got partial remission (PR), accounting for 60.00 %, 26 cases had no change (NC), accounting for 23.64 %, and 8 cases were in progressive disease ( PD), accounting for 7.27 %. The clinical benefit rate was 69.96 %. Clinical symptoms of RP were found in 22 cases(20 %) of the 110 patients. Single factor analysis showed Karnofsky performance score (KPS), chronic obstructive pulmonary disease(COPD).Conclusion: chemotherapy, the radiation dose for gross tumor volume(GTV), lung V20, mean lung dose (MLD) and target volume of radiation (PTV) were associated with RP.Conclusion: KPS.Conclusion chemotherapy, COPD, lung V20, MLD, PTV, GTV and PTV are main risk factors of RP induced by radiotherapy for patients with esophageal cancer .
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