临床医学论著

高危型HPV检测联合TCT检查在宫颈癌筛查中的应用

  • 朱婉枝 ,
  • 王巧玲
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  • 广州市白云区太和镇卫生院妇产科,广东广州 510445

收稿日期: 2017-01-05

  网络出版日期: 2017-09-26

Application of high-risk HPV test combined with TCT detection in cervical cancer screening

  • ZHU Wanzhi ,
  • WANG Qiaoling
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  • Obstetrics and Gynecology Department of Taihe Town Health Center, Baiyun District of Guangzhou City, Guangzhou 510445, China

Received date: 2017-01-05

  Online published: 2017-09-26

摘要

目的: 探究高危型人乳头瘤病毒(HPV)检测联合薄层液基细胞学检查(thin-cytologic test,TCT)检查在宫颈癌筛查中的应用价值。方法: 选取接受宫颈癌筛查的患者121例,分别进行高危型HPV检测和TCT检查,并以阴道镜病理组织活检结果为诊断标准,比较单纯行TCT检查或单纯行高危型HPV检测及高危型HPV检测联合TCT检查的结果。结果: 高危型HPV联合TCT检查宫颈癌的准确性较单纯TCT检查或单纯行高危型HPV提高(P<0.05);高危型HPV联合TCT检查的敏感性、特异性、阳性预测值及阴性预测值优于单纯HPV检测或单纯行TCT检查(P<0.05)。结论: 高危型HPV检测联合TCT检查诊断宫颈癌具有较高的准确性,且敏感性及特异性较高,值得临床推广。

本文引用格式

朱婉枝 , 王巧玲 . 高危型HPV检测联合TCT检查在宫颈癌筛查中的应用[J]. 包头医学院学报, 2017 , 33(9) : 46 -48 . DOI: 10.16833/j.cnki.jbmc.2017.09.018

Abstract

Objective: To investigate the application value of high-risk human papilloma virus (HPV) test combined with thin-cytologic test (TCT) detection in cervical cancer screening.Methods: 121 cases of patients under cervical cancer screening in the hospital were selected and given high-risk HPV test and TCT detection respectively. The results of colposcopic histopathological biopsy were taken as diagnostic standard, and the results of TCT detection alone, high-risk HPV test alone and high-risk HPV test combined with TCT detection were compared.Results: The accuracy of the result of high-risk HPV combined with TCT detection significantly increased compared with that of TCT detection alone or high-risk HPV test alone in the detection rate of cervical cancer (P<0.05); The sensitivity, specificity, positive predictive value and negative predictive value of high-risk HPV combined with TCT detection were significantly better than those of HPV test alone or TCT detection alone (P<0.05).Conclusion: High-risk HPV test combined with TCT detection in the diagnosis of cervical cancer has higher accuracy, sensitivity and specificity, which is worthy of clinical promotion.

参考文献

[1] 许惠惠,石卫武,徐玖飞,等.HPV 基因分型在宫颈癌筛查风险分层管理中的价值[J].中华实验和临床病毒学杂志,2016,30(1):14-18.
[2] 张肖青,徐惠群.人乳头瘤病毒分型检测对宫颈病变患者的诊断价值[J].中国临床医学,2016,23(2):164-166.
[3] 姜爱凤,王以新,杨敏京,等.新柏式薄层液基细胞学(TCT)联合HPV-DNA 分型检测在宫颈癌筛查中的临床价值[J].现代肿瘤医学,2015,23(20):3015-3017.
[4] 穆成柱,韩兰芳,方建平,等.高危型人乳头状瘤病毒检测联合细胞学检查在宫颈病变筛查中的应用[J].中国药物与临床,2016,16(7):1073-1074.
[5] 汤雯剑,马艳侠.人乳头瘤病毒基因分型联合液基薄层细胞学检测在宫颈疾病检查中的意义[J].检验医学与临床,2015,12(11):1618-1619,1621.
[6] 张淼,周秀春,张冠群.人乳头瘤病毒检测及TCT检查在宫颈癌筛查中的临床价值研究[J].现代预防医学,2016,43(5):836-838,918.
[7] 马春华,吐尔逊阿衣·买买提明,王琳,等.高危型HPV 基因型检测在新疆宫颈癌筛查中的临床应用价值[J].中国生育健康杂志,2016,27(5):432-437.
[8] 李宇,邱桂清.TCT联合HR-HPV对宫颈癌前病变的诊断价值[J].浙江临床医学,2016,18(7):1344-1345.
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