目的: 探究高危型人乳头瘤病毒(HPV)检测联合薄层液基细胞学检查(thin-cytologic test,TCT)检查在宫颈癌筛查中的应用价值。方法: 选取接受宫颈癌筛查的患者121例,分别进行高危型HPV检测和TCT检查,并以阴道镜病理组织活检结果为诊断标准,比较单纯行TCT检查或单纯行高危型HPV检测及高危型HPV检测联合TCT检查的结果。结果: 高危型HPV联合TCT检查宫颈癌的准确性较单纯TCT检查或单纯行高危型HPV提高(P＜0.05);高危型HPV联合TCT检查的敏感性、特异性、阳性预测值及阴性预测值优于单纯HPV检测或单纯行TCT检查(P＜0.05)。结论: 高危型HPV检测联合TCT检查诊断宫颈癌具有较高的准确性,且敏感性及特异性较高,值得临床推广。

Objective: To investigate the application value of high-risk human papilloma virus (HPV) test combined with thin-cytologic test (TCT) detection in cervical cancer screening.Methods: 121 cases of patients under cervical cancer screening in the hospital were selected and given high-risk HPV test and TCT detection respectively. The results of colposcopic histopathological biopsy were taken as diagnostic standard, and the results of TCT detection alone, high-risk HPV test alone and high-risk HPV test combined with TCT detection were compared.Results: The accuracy of the result of high-risk HPV combined with TCT detection significantly increased compared with that of TCT detection alone or high-risk HPV test alone in the detection rate of cervical cancer (P＜0.05); The sensitivity, specificity, positive predictive value and negative predictive value of high-risk HPV combined with TCT detection were significantly better than those of HPV test alone or TCT detection alone (P＜0.05).Conclusion: High-risk HPV test combined with TCT detection in the diagnosis of cervical cancer has higher accuracy, sensitivity and specificity, which is worthy of clinical promotion.