目的: 探讨不同性别类风湿关节炎(rheumatoid arthritis,RA)患者的临床特征。方法: 收集2006年7月至2015年1月风湿免疫科确诊的RA患者404例,按性别分为男性、女性两组,了解不同性别RA患者一般情况、实验室检查、脏器受累情况。结果: 患者发病年龄男性＞女性(t=2.415,P=0.016),住院年龄比较差异无统计学意义(P＞0.05);男性患者关节畸形54例、膝关节受累117例、口干51例、眼干28例、合并高血压11例、合并骨质疏松17例;女性患者关节畸形126例、膝关节受累202例、口干123例、眼干84例、合并高血压52例、合并骨质疏松43例,两组比较差异具有统计学意义(P＜0.05);男性患者抗核抗体(ANA)阳性59例,34例血小板升高,32例血红蛋白减少,血沉(ESR)异常117例,肌酐异常14例;女性患者ANA阳性125例、血小板升高71例、血红蛋白减少73例、ESR异常202例、肌酐异常6例,两组间比较差异具有统计学意义(P＜0.05)。在C反应蛋白(CRP)、血红蛋白、白细胞、抗环瓜氨酸肽抗体(CCP)阳性、抗角蛋白(AKA)阳性方面,男女比较差异均无统计学意义(P＞0.05)。结论: 女性易出现关节畸形、膝关节受累、口干、眼干、合并高血压、合并骨质疏松,在ANA阳性率、血小板升高、血红蛋白减少、ESR升高方面均高于男性,肌酐异常男性高于女性。

Objective: to discuss the clinical features of rheumatoid arthritis (RA) in patients of different gender.Methods: 1 248 patients who were diagnosed with RA from July 2006 to January 2015 were collected and divided into Group Male and Group Female, with the general situation, laboratory examination and the involved heart learned.Results: The incidence age of the male patients were older than that of the female patients (P=0.016), there being no statistical significance (P＞0.05) . There were 54 cases of joint deformities, 117 cases of involved knee joints, 51 cases of dry mouths, 28 cases of dry eyes, 11 cases of combined high blood pressure and 17 cases of osteoporosis among male patients while there were 126 cases, 202 cases, 123 cases, 84 cases, 52 cases and 43 cases respectively in female patients , the difference being significant (P＜0.05). There were 59 cases of positive ANA , 34 cases of elevated platelets, 32 cases of reduced hemoglobin, 117case of abnormal ESR , 14 cases of abnormal creatinine abnormalities in male patients while there were 125 cases, 71 cases, 71 cases, 202 cases and 6 cases respectively in female patients , the significance being different (P＜0.05). There were no difference in terms of CRP, hemoglobin, white blood cells, positive anti-CCP and positive AKA between men and women (P＞0.05).Conclusion: The elderly men were susceptible to RA, while elderly women were susceptible to joint deformities, knee joint involvement,dry mouths, dry eyes, combined high blood pressure and combined osteoporosis. There were more ANA positive rates, increased platelets, hemoglobin and increased ESR in female patients than in male patients. There was more elevated serum creatinine in men than in women.