光动力和声动力疗法治疗恶性肿瘤的研究进展

杨利青; 郭团魁

doi:10.16833/j.cnki.jbmc.2026.05.015

包头医学院学报 >

2026 , Vol. 42 >Issue 5: 89 - 96

DOI: https://doi.org/10.16833/j.cnki.jbmc.2026.05.015

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光动力和声动力疗法治疗恶性肿瘤的研究进展

杨利青 ,
郭团魁

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1.包头市第四医院,内蒙古包头 014030;
2.包头市肿瘤医院

郭团魁

收稿日期: 2025-12-09

网络出版日期: 2026-07-16

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Comparative research progress of photodynamic and sonodynamic therapy in the treatment of malignant tumors

YANG Liqing ,
GUO Tuankui

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1. The Fourth Hospital of Baotou, Baotou 014030, China;
2. Baotou Cancer Hospital

Received date: 2025-12-09

Online published: 2026-07-16

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摘要

光动力(photodynamic therapy, PDT)和声动力(sonodynamic therapy, SDT)疗法是两种基于活性氧(reactive oxygen species, ROS)杀伤肿瘤细胞的非侵入性癌症治疗方法。PDT经光激活光敏剂、SDT由超声激活声敏剂发挥作用,二者均具有组织穿透性强、靶向性高及可联合放化疗的优势。近二十年,二者在敏化剂开发、机制解析及临床应用方面取得了显著进展,但仍受限于敏化剂生物相容性欠佳、深层肿瘤穿透效率低及个体化治疗方案不足等问题,未来需聚焦新型敏化剂设计、参数优化及多疗法联合,以推动其成为恶性肿瘤治疗的重要选择。本文通过文献综述与数据分析,系统总结了PDT与SDT的研究现状与发展趋势。

关键词： 光动力; 声动力; 光敏剂; 声敏剂; 活性氧物质; 恶性肿瘤治疗

本文引用格式

杨利青 , 郭团魁 . 光动力和声动力疗法治疗恶性肿瘤的研究进展[J]. 包头医学院学报, 2026 , 42(5) : 89 -96 . DOI: 10.16833/j.cnki.jbmc.2026.05.015

Abstract

Photodynamic therapy (PDT) and sonodynamic therapy (SDT) are two non-invasive cancer treatment methods based on reactive oxygen species (ROS) killing tumor cells. PDT is activated by light-activated photosensitizer and SDT is activated by ultrasound-activated sonosensitizer. Both of them have the advantages of strong tissue penetration, high targeting and combined radiotherapy and chemotherapy. In the past two decades, significant progress has been made in the development, mechanism analysis and clinical application of sensitizers, but they are still limited by the poor biocompatibility of sensitizers, low penetration efficiency of deep tumors and insufficient individualized treatment options. In the future, it is necessary to focus on the design of new sensitizers, parameter optimization and multi-therapy combination to promote them to become an important choice for the treatment of malignant tumors. Through literature review and data analysis, this paper systematically summarizes the research status and development trend of PDT and SDT, and provides a theoretical basis for their clinical transformation.

Key words： Photodynamic; Sonodynamic; Photosensitizer; Sonosensitizer; Active oxygen substances; Malignant tumor treatment

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