Objective: To investigate the clinical efficacy of Dayuanyin Huazhu decoction combined with calcium dobesilate in the treatment of patients with non-proliferative diabetic retinopathy (NPDR). Methods: From August 2021 to October 2022, 50 patients (100 eyes) diagnosed with non-proliferative diabetic retinopathy in the Department of Ophthalmology, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology were selected. According to the random number remainder grouping method, they were divided into western medicine control group (group A, simple oral administration of western medicine calcium dobesilate capsules, 25 cases with 50 eyes) and combined medication study group (group B, oral administration of Dayuanyin Huazhuo decoction combined with calcium dobesilate capsules, 25 cases with 50 eyes). The changes of blood glucose (fasting blood glucose, glycosylated hemoglobin) before and after 12 weeks of treatment, best corrected distant vision, number of fundus microangiomas, bleeding and exudation area, and TCM syndrome scores were compared between the two groups were observed and recorded. Results: During the medication period, the blood glucose control of the subjects remained stable. After 12 weeks of treatment, the overall effective rates of best corrected visual acuity (BCVA) for Group A and Group B were 72.00% and 80.00%, respectively; the overall effective rates for improvement in fundus symptoms (including the number of microaneurysms, bleeding, and area of exudation) were 68.00% and 80.00%, respectively, with Group B showing significantly better results than Group A (P＜0.05). The overall effective rates of traditional Chinese medicine symptom efficacy for Group A and Group B were 64.00% and 84.00%, respectively, also indicating Group B performed better than Group A (P＜0.05). The decrease in fasting blood glucose and glycated hemoglobin levels in Group B is significantly greater than that in Group A (inter-group comparison for fasting blood glucose P=0.0058, inter-group comparison for glycated hemoglobin P=0.035).Group B outperformed Group A in improving fundus lesions, vision, fasting blood glucose, glycated hemoglobin, and traditional Chinese medicine symptom scores (P＜0.05). Conclusion: The combination of traditional Chinese medicine Da Yuan Drink for clearing turbidity and the Western medicine calcium p-hydroxybenzenesulfonate has shown good efficacy in the treatment of NPDR, and it is worth promoting in clinical applications.
ZHANG Yukun
,
CHANG Ying
,
HE Jing
,
BAI Yun
,
WU Bin'ge
. Observation on the curative effect of combined traditional Chinese and western medicine treatment for diabetic retinopathy[J]. Journal of Baotou Medical College, 2026
, 42(3)
: 27
-32
.
DOI: 10.16833/j.cnki.jbmc.2026.03.006
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