Objective: To investigate the relationship between ABCG2 ( rs2231142 ) allele distribution and hyperuricemia (HUA) in men in Inner Mongolia. Methods: A case-control study was conducted to select 408 males who underwent physical examination in the physical examination center of the Fourth Hospital of Baotou from September 2023 to April 2024, including 202 cases in HUA group and 204 cases in non-HUA group. KASP-competitive allele-specific PCR was used to detect gene polymorphism. The χ2 test was used for comparison between allele groups, and the relationship between allele and male HUA was analyzed by Logistic regression. Results: The distribution frequencies of alleles G and T of ABCG2 (rs2231142) locus in the HUA group were 65.3% and 34.7% respectively, while those in the non-HUA group were 71.8% and 28.2% respectively. There was a difference in the frequency distribution between the two groups (P=0.047). The minor allele T was associated with HUA in men, and compared with men carrying allele G, men carrying allele T had an increased risk of HUA (OR=1.358, 95%CI: 1.005-1.836). Stratified analysis of age showed that minor allele T was associated with the occurrence of HUA in men aged 40-60 years old, which was the influencing factor of HUA in men of this age group (OR=1.477, 95%CI:1.003-2.173). Conclusion: In the male population in Inner Mongolia, the T allele of ABCG2 (rs2231142) locus presents a relatively higher proportion in individuals with HUA. The minor allele T is associated with an increased risk of HUA in local males, and this risk association is more significant in men aged 40 to 60 years.
HUA Lu
,
GE Chen
,
WANG Cuifeng
. Correlation analysis between ABCG2 allele distribution and hyperuricemia in men in Inner Mongolia[J]. Journal of Baotou Medical College, 2026
, 42(3)
: 7
-10
.
DOI: 10.16833/j.cnki.jbmc.2026.03.002
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