Research progress on tuberculosis vaccines based on recombinant viral vectors

  • WANG Jianghong ,
  • WANG Xiaochun ,
  • XIA Lu ,
  • PI Xinxin ,
  • WU Jiagao
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  • Anhui University of Science and Technology, Huainan 232001, China

Received date: 2025-02-23

  Online published: 2026-04-02

Abstract

Tuberculosis is still a serious public health threat around the world. However, bacillus calmette-guérin (BCG), the only licensed vaccine, has limited efficacy. In recent decades, viral vector vaccines have developed rapidly. Recombinant live virus vector vaccine can simulate the process of pathogen invasion and induce immune response, and has the ability to form long-term immune memory and strong immune protection. This paper reviews the latest research progress of tuberculosis virus vector vaccines, systematically reviews the tuberculosis virus vector vaccines undergoing clinical trials, and evaluates and summarizes the candidate vaccines with development potential in the early stage of development. This article may provide theoretical and practical support for the development of a more effective tuberculosis recombinant virus vector vaccine.

Cite this article

WANG Jianghong , WANG Xiaochun , XIA Lu , PI Xinxin , WU Jiagao . Research progress on tuberculosis vaccines based on recombinant viral vectors[J]. Journal of Baotou Medical College, 2026 , 42(1) : 85 -90 . DOI: 10.16833/j.cnki.jbmc.2026.01.015

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