Objective: To investigate the correlation between magnetic resonance iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence (IDEAL-IQ) parameters [fat fraction (FF) and R2* relaxation rate] and bone mineral density (BMD), to analyze their differences between sexes, and to specifically evaluate the evolution of the bone marrow microenvironment in perimenopausal women. Methods: The data of 65 subjects who underwent lumbar DXA and 3.0T MRI were retrospectively analyzed. According to the DXA T value, the patients were divided into normal bone mass group, osteopenia group and osteoporosis group. Male subjects were included as gender controls, and the differences in IDEAL-IQ parameters between different genders were compared. The female subjects were further grouped according to the years of menopause, and the dynamic changes of FF and R2 * values were analyzed. Results: (1) At the overall level: with the loss of bone mass, the FF value increased (P＜0.001) and the R2* value decreased (P＜0.001), both of which were highly correlated with BMD (P＜0.001). The efficacy of R2* in the diagnosis of osteoporosis (AUC=0.887) was better than that of FF. (2) Gender differences: The vertebral R2* value of female was lower than that of male (P＜0.05), suggesting that there was a specific decrease in bone marrow iron reserve and microstructure magnetic sensitivity in women. There was no significant difference in FF value between the male and female (P＞0.05). (3) Perimenopausal characteristics: The FF value of female increased with the extension of menopausal years (P＜0.05), which was manifested as the rapid accumulation of bone marrow fat in early menopause. Conclusion: IDEAL-IQ technology can noninvasively and quantitatively evaluate the changes of bone marrow fat metabolism. R2* value is a sensitive index to reflect the gender difference of osteoporosis, and FF value can sensitively capture the bone marrow transformation process of perimenopausal women. This technology is expected to be an effective supplement to DXA, especially for early screening of perimenopausal women.
WANG Mengjiao
,
LIU Zhenzhen
,
CHEN Qiang
,
WU Chunyan
,
LUO Lin
. Study on gender differences and perimenopausal effects of MRI IDEAL-IQ quantitative parameters in lumbar osteoporosis[J]. Journal of Baotou Medical College, 2026
, 42(1)
: 69
-74
.
DOI: 10.16833/j.cnki.jbmc.2026.01.012
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