Objective: To investigate the role of the FRMD4B gene in various cancers and its association with prognosis, immune microenvironment. Methods: Data of 33 tumors were obtained from TCGA and UCSC Xena databases and analyzed FRMD4B in Perl and R. Evaluated its correlation with prognosis, clinical phenotype, tumor mutation burden (TMB), microsatellite instability (MSI), immune infiltration. And explored its mutational characterization, subcellular localization, and more with online tools. Results: The expression level of FRMD4B mRNA in various tumor tissues was lower than that in corresponding normal tissues (P＜0.001). The results of four survival analysis showed that FRMD4B expression was associated with tumor-specific survival (P＜0.05). In some tumors, FRMD4 B showed different correlations with TMB, MSI, matrix score and immune score (P＜0.05). FRMD4B expression exhibited varying degrees of correlation with TMB, MSI, stromal score and immune score in different tumor types(P＜0.05). Immunohistological analysis showed that FRMD4B was significantly correlated with immune cells in a variety of tumors(P＜0.001) and positively correlated with the majority of immune-related genes. Gene-set enrichment analysis showed that high expression FRMD4B was significantly enriched in biological processes such as immune pathways and cell cycle. Its mutations were mainly missense mutations. Its interacting proteins included CYTH1, GPA33, HSPB7 and PLEKHA5. The subcellular localization was primarily observed in the cytoplasmic and cytoskeletal regions. Conclusion: FRMD4B plays a critical role in a variety of cancers and is closely related to tumor development, prognosis and immune environment. It may become a potential biomarker and therapeutic target for precision cancer therapy.
WANG Zizhen
,
XU Hao
,
QIAN Gege
,
LI Jiahui
,
ZHANG Yao
,
BAI Zijian
,
ZHANG Wen
,
LI Xinyi
,
RUI Yutong
,
CHEN Bing
. Role of FRMD4B in pan-cancer and its association with prognosis and immune microenvironment[J]. Journal of Baotou Medical College, 2026
, 42(1)
: 47
-55
.
DOI: 10.16833/j.cnki.jbmc.2026.01.009
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