Objective: To explore the mechanism of Trollius chinensis Bunge in the treatment of chronic sinusitis by network pharmacology and molecular docking. Methods: Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and other databases were used to screen the active ingredients and potential targets in Trollius chinensis Bunge. GeneCards and other databases were used to search for disease-related targets; the compound target-disease Venn diagram was constructed, and the intersection target between drug target and disease target was obtained. Cytoscape 3.9.1 software was used to draw the drug-component-target-disease network diagram. The PPI network diagram of protein-protein interaction was constructed by STRING database and Cytoscape. R4.2.1 software clusterProfiler package was used to perform gene ontology (GO) function and kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis, and Cytoscape was used to construct a drug-component-target-pathway network diagram. Molecular docking of key active ingredients and core targets was performed using AutoDockTools. Results: Through database screening, 14 active ingredients, 507 active ingredient targets, 829 disease-related targets and 160 common targets were obtained. Quercetin, acacetin, β-sitosterol, dihydroquercetin and luteolin were the core components of Trollius chinensis Bunge in the treatment of chronic sinusitis. Protein interaction network analysis showed that the core targets may be through signal transducer and activator of transcription 3 (STAT3), the tumor necrosis factor (TNF), interleukin-6 (IL-6), TP53, AKT1, SRC and other six core targets. GO and KEGG enrichment analysis showed that STAT3, TNF, IL-6 and other signaling pathways played an anti-inflammatory role. The results of molecular docking showed that the core components of Trollius chinensis had good binding ability with the core targets. Conclusion: Quercetin, acacetin, β-sitosterol and other active ingredients in Trollius chinensis Bunge may regulate STAT3, IL-6, TNF, TP53, AKT1, SRC and other targets to regulate multiple signaling pathways, reduce the secretion of inflammatory factors, regulate the occurrence and development of inflammation, so as to play a role in the treatment of chronic sinusitis.
ZHOU Yuqian
,
DU Yan
,
YANG Meiqing
. The mechanism of Trollius chinensis Bunge in the treatment of chronic sinusitis based on network pharmacology and molecular docking[J]. Journal of Baotou Medical College, 2026
, 42(1)
: 35
-41
.
DOI: 10.16833/j.cnki.jbmc.2026.01.007
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