Objective: To investigate the expression and prognostic value of transmembrane protein 206 (TMEM206) in thyroid cancer (TC). Methods: Standardized mean difference combined with random effect model was used to analyze the difference of TMEM206 expression between TC and non-cancerous thyroid tissues in multi-center samples, and Kaplan-Meier method was used to evaluate its prognostic value. Results: The expression of TMEM206 mrna in TC tissues was higher than that in non-cancerous thyroid tissues (SMD=0.42, 95%CI: 0.08-0.77), and Egger and Begg tests showed no significant bias (P＞0.05). The expression characteristics of TMEM206 mrna were evaluated by receiver operating characteristic curve, with a sensitivity of 0.57 (95%CI: 0.39-0.74) and a specificity of 0.84 (95%CI: 0.58-0.95), the positive likelihood ratio was 3.57 (95%CI: 1.36-9.38), and the negative likelihood ratio was 0.51 (95%CI: 0.36-0.72). At the protein level, the expression of TMEM206 in TC tissues was significantly higher than that in non-cancerous tissues (P＜0.05). Conclusion: TMEM206 is highly expressed in TC, suggesting that it may be involved in the pathological process of TC, and its molecular mechanism needs to be clarified through functional experiments in the future.
QIN Kai
,
MO Junyang
,
QIN Shuting
,
SONG Chang
,
QU Ning
,
CHEN Gang
,
PANG Yuyan
. Expression oftransmembrane protein 206 in thyroid cancer and its prognostic value[J]. Journal of Baotou Medical College, 2025
, 41(12)
: 51
-55
.
DOI: 10.16833/j.cnki.jbmc.2025.12.010
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