Objective: To investigate the expression of olfactory protein-like 2B (OLFML2B) in colon cancer tissues. Methods: The gene expression difference of OLFML2B in pan-cancer was analyzed by TCGA database. The expression levels of OLFML2B, phosphorylated protein kinase B (p-AKT), transcription factor MYB and cyclin D1 (CCND1) in cancer tissues and adjacent normal tissues of patients with colon cancer were detected by immunohistochemistry and Western blotting, and the potential links of these proteins in the development of colon cancer were analyzed. Results: In the pan-cancer study, the expression of OLFML2B was significantly different in various tumor tissues, and it was highly expressed in a variety of tumor tissues, such as colon cancer, lung adenocarcinoma, renal clear cell carcinoma, gastric adenocarcinoma, hepatocellular carcinoma, etc. (P＜0.05). In TCGA-COAD paired samples, OLFNL2B was highly expressed in colon cancer. Immunohistochemistry and Western blot analysis showed that the expression levels of OLFML2B, p-AKT, MYB and CCND1 in colon cancer tissues were significantly higher than those in adjacent normal tissues (P＜0.05). Spearman correlation analysis showed that OLFML2B was positively correlated with the expression of p-AKT, MYB and CCND1 in colon cancer (P＜0.05). Conclusion: OLFML2B, p-AKT, MYB and CCND1 are highly expressed in colon cancer, which may promote the occurrence and development of cancer through interaction, and its mechanism may be related to phosphatidylinositol-3-hydroxykinase (PI3K/Akt) signaling pathway.
WANG Menghan
,
WANG Mizhu
. Expression of olfactomedin-like 2B in colon cancer[J]. Journal of Baotou Medical College, 2025
, 41(12)
: 46
-50
.
DOI: 10.16833/j.cnki.jbmc.2025.12.009
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