LU Luochuan , WEN Wenxin , TIAN Yuning , HU Yi , XIE Yabin , Baderengui . Research progress on neuroprotective effect of ischemic/hypoxic preconditioning[J]. Journal of Baotou Medical College, 2025 , 41(9) : 84 -88 . DOI: 10.16833/j.cnki.jbmc.2025.09.014

[1] Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium[J]. Circulation, 1986, 74(5): 1124-1136.
[2] 何克, 孙官军, 彭旭, 等. 间歇性低氧预适应对力竭运动大鼠心肌自噬蛋白表达及相关通路的影响[J]. 心脏杂志, 2022, 34(5): 502-509.
[3] 孙梦雅, 李婷, 姜红. 氙气对新生儿缺氧缺血性脑病的神经保护作用及其可能机制[J]. 中华围产医学杂志, 2023, 26(4): 339-343.
[4] 付竹, 丁娜, 胡志斌, 等. 紫檀芪调节LKB1/AMPK信号通路减轻缺氧缺血性脑损伤新生大鼠氧化应激损伤[J]. 儿科药学杂志, 2023, 29(6): 1-5.
[5] 赵健衡, 王丽, 蒋燕, 等. 丙泊酚调节SIRT1/HMGB1/NF-κB信号通路对缺血缺氧性脑损伤新生大鼠神经元损伤的影响[J]. 中国优生与遗传杂志, 2023, 31(4): 708-714.
[6] 周璐, 唐丽亚, 蒋琼, 等. 运动预处理对脑缺血再灌注损伤大鼠缺血区脑组织血管新生及HIF-1α和VEGF蛋白表达的影响[J]. 中华物理医学与康复杂志, 2024, 46(1): 1-6.
[7] Zhu T, Zhan L, Liang D, et al. Hypoxia-inducible factor 1α mediates neuroprotection of hypoxic postconditioning against global cerebral ischemia[J]. J Neuropathol Exp Neurol, 2014, 73(10): 975-986.
[8] Shao G, Gao CY, Lu GW. Alterations of hypoxia-inducible factor-1 alpha in the hippocampus of mice acutely and repeatedly exposed to hypoxia[J]. Neurosignals, 2005, 14(5): 255-261.
[9] 付孝娟, 赵源征. K+ATP通道开放剂尼可地尔对缺血性脑卒中小鼠模型的脑保护作用及机制[J]. 中国神经免疫学和神经病学杂志, 2023, 30(1): 25-29, 38.
[10] Stenzel-Poore MP, Stevens SL, Xiong Z, et al. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states[J]. Lancet, 2003, 362(9389): 1028-1037.
[11] 于馨雅, 申元英, 郭乐. Nrf2/HO-1通路在氧化应激和炎性反应中的作用[J]. 医学研究杂志, 2023, 52(7): 19-22.
[12] 董秀, 包红, 韩兆丰. 去甲斑蝥素诱导超氧阴离子的产生介导HeLa细胞线粒体途径的细胞凋亡[J]. 吉林中医药, 2021, 41(8): 1070-1073.
[13] Sheng R, Liu XQ, Zhang LS, et al. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning[J]. Autophagy, 2012, 8(3): 310-325.
[14] 朱博超, 李彦杰, 秦合伟, 等. 针刺通过TLR4/NF-KB信号通路调控炎症反应治疗中枢神经系统疾病的作用机制研究进展[J]. 中医药导报, 2023, 29(2): 160-165.
[15] 杨静, 侯冰, 武文清, 等. 低氧预适应对小鼠海马神经元细胞的保护作用及其相关基因[J]. 华夏医学, 2023, 36(4): 32-37.
[16] Cui GH, Wu J, Mou FF, et al. Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice[J]. FASEB J, 2018, 32(2): 654-668.
[17] Miranda CTCBC, Fagundes DJ, Miranda E, et al. The role of ischemic preconditioning in the expression of apoptosis-related genes in a rat model of intestinal ischemia-reperfusion injury[J]. Acta Cirurgica Brasileira, 2019, 34(5): e201900501.
[18] Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials[J]. Lancet, 2014, 384(9958): 1929-1935.
[19] Mazumdar J, O′brien WT, Johnson RS, et al. O₂ regulates stem cells through Wnt/β-catenin signalling[J]. Nat Cell Biol, 2010, 12(10): 1007-1013.
[20] 郭漫, 沈道琪, 於佳炜, 等. miR-21对肾脏缺血/缺氧耐受中血管适应性调整的调控作用[J]. 中国中西医结合肾病杂志, 2023, 24(9): 768-772,后插1.
[21] Lalu MM, Montroy J, Dowlatshahi D, et al. From the lab to patients: a systematic review and meta-analysis of mesenchymal stem cell therapy for stroke[J]. Transl Stroke Res, 2020, 11: 345-364.