Objective: To investigate the clinical significance of serum uric acid (UA) and homocysteine (Hcy) levels in patients with Parkinson′s disease (PD) complicated with cognitive impairment. Methods: A total of 96 patients with PD who were admitted from January 2017 to January 2022 were selected and divided into three groups according to the Montreal Cognitive Assessment Scale score. Group A was the PD cognitive normal group (34 patients), group B was the PD mild cognitive impairment group (32 patients), and group C was the PD dementia group (30 patients). Group D was the control group, which was composed of healthy subjects (50 patients). The levels of UA and Hcy in each group were detected, and the significance of the differences in each index was analyzed. Results: Compared with group D, the level of UA was lower and the level of Hcy level were higher in groups A, B and C, and the differences were statistically significant (P＜0.01). Compared with group A, the level of UA was lower and the level of Hcy was higher in group B and group C, the differences were statistically significant (P＜0.05). The level of UA in group C was lower than that in group B, and the level of Hcy was higher than that in group B (P＜0.05). Conclusion: The decrease of UA and the increase of Hcy level in PD patients may reflect the degree of cognitive impairment in PD patients to a certain extent.
FAN Guiling
,
WEN Jie
. Evaluation of the expression levels of UA and Hcy in Parkinson′s disease patients with cognitive impairment[J]. Journal of Baotou Medical College, 2025
, 41(9)
: 68
-70
.
DOI: 10.16833/j.cnki.jbmc.2025.09.011
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