Objective: To investigate the expression levels and clinical significance of circRNA-GRHPR in carotid atherosclerosis (CAS). Methods: A total of 124 patients were randomly selected from the Third Department of Neurology, the First Affiliated Hospital of Baotou Medical College. These patients were divided into the control group and the case group based on whether they had atherosclerosis (AS) in the carotid artery as shown by imaging examinations. In the control group, 30 patients had no plaques found in the carotid arteries; in the case group, 94 patients had plaques in the carotid arteries, which were either hard, soft, or mixed. Real-time quantitative PCR (qRT-PCR) was used to verify differential expression of circRNA-GRHPR in cells and to further analyze the role of circRNA-GRHPR in CAS. Results: The occurrence of CAS was associated with gender, age, systolic blood pressure, smoking history, alcohol consumption history, hypertension history, and peripheral blood circRNA-GRHPR expression levels, all of which were positively correlated (P＜0.05); HDL-C was associated with CAS but negatively correlated (P＜0.05). The peripheral blood circRNA-GRHPR expression level in the case group was higher than that in the control group (P＜0.05). Conclusion: The occurrence of CAS is significantly related to the expression levels of circRNA-GRHPR in patients′ serum, potentially serving as an improved diagnostic tool and a new therapeutic target for AS, paving the way for early intervention measures.
LIU Bo
,
LIU Dan
,
ZHANG Guangwei
,
JIANG Xiaoling
. Expression levels and clinical significance of circRNA-GRHPR in acute cerebral infarction[J]. Journal of Baotou Medical College, 2025
, 41(9)
: 56
-62
.
DOI: 10.16833/j.cnki.jbmc.2025.09.009
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