Objective: To study the status quo and correlation of medication compliance in patients with rheumatoid arthritis (RA) at home, in order to provide a theoretical basis for improving patients' medication compliance. Methods: A total of 110 RA patients receiving home-based care from the second affiliated hospital of Shandong first medical university were selected as study subjects between March 2024 and June 2024. Assessments were conducted using the Chinese version of the Morisky Medication Adherence Questionnaire-8 (MMAS-8), the Health Assessment Questionnaire (HAQ), and a self-designed basic information survey form. Results: The score of medication compliance of RA patients at home was (4.55±1.63), there were 0 patient (0%) with good medication compliance, 35 patients (31.82%) with moderate medication compliance, and 75 patients (68.18%) with poor medication compliance, the medication compliance was 31.82%. The HAQ score was (10.75±11.84), which was the middle level of the health assessment scale. The health assessment score of RA patients at home was negatively correlated with medication compliance. Age, education level, duration of morning stiffness and health status were the influencing factors of medication compliance. Conclusion: The medication compliance of RA patients at home is poor. Medical staff should take into account the difference of age and education level of patients in clinical and continuous nursing work, and pay attention to the influence of medication compliance on morning stiffness and health status, and formulate individualized health education and chronic disease management strategies according to the patient's condition, so as to improve the medication compliance of RA patients at home.