Objective: To analyze the distribution and drug resistance of pathogenic bacteria in cerebrospinal fluid infection in Baotou area of Inner Mongolia. Methods: The clinical data of 244 patients with positive cerebrospinal fluid culture from 2013 to 2024 in our hospital were collected. The samples were isolated, identified and tested for drug sensitivity, and the biochemical indexes of different pathogenic bacteria were compared. Results: Among the positive bacteria in cerebrospinal fluid culture, Gram-positive bacteria, Gram-negative bacteria and fungi accounted for 65.2%, 33.2% and 1.6%, respectively. Epidemiological studies showed that there were significant differences in the distribution of pathogens in different seasons (P＜0.05), while Staphylococcus epidermidis (16.7%) was common in summer, Staphylococcus capitis (13.4%) and Acinetobacter baumannii (11.9%) were common in autumn, and Staphylococcus aureus (10.3%) and Klebsiella pneumoniae (8.6%) were common in winter. There was no significant difference in the age distribution of pathogenic bacteria, but the content of Streptococcus pneumoniae was the higher in the age group of ≤12 years old, and the proportion of Acinetobacter baumannii was the highest in the age group of ≥60 years old. The results of drug sensitivity showed that Staphylococcus strains had no resistance to linezolid and vancomycin. Streptococcus pneumoniae had no resistance to ofloxacin and teicoplanin. Acinetobacter baumannii had no resistance to cefoperazone/sulbactam; the effect of carbapenem in the treatment of Escherichia coli was better; Klebsiella pneumoniae was sensitive to imipenem and meropenem. Conclusion: Staphylococeus epidermidis are more common in cerebrospinal fluid infections from 2013 to 2024. In addition, the significant differences in pathogens in different seasons can provide valuable strategies for disease prevention and improvement of evidence-based treatment.
WANG Xingyu
,
YAN Xiaoxia
,
ZHANG Jiarui
,
ZHANG Jing
,
MA Licong
. Epidemiological characteristics and drug resistance analysis of cerebrospinal fluid microbial infections in Baotou Area[J]. Journal of Baotou Medical College, 2025
, 41(6)
: 6
-12
.
DOI: 10.16833/j.cnki.jbmc.2025.06.002
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