Objective: To study the serum levels of pentraxin-3 (PTX3) and 25-hydroxyvitamin [25(OH)2D3] in patients with type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP) and their correlation with the disease and diagnostic value. Methods: Patients diagnosed with OP in Baotou Fourth Hospital from October 1, 2022 to October 1, 2023 were selected as the research objects. According to the fasting blood glucose results of OP patients, the patients with T2DM combined with OP were set as group A (31 patients), and the patients with simple OP were set as group B (29 patients). At the same time, the patients with normal bone mass in the same period were selected as the control group, namely group C (29 patients). The levels of PTX3 and 25(OH)2D3 in serum of each group were detected by enzyme-linked immunosorbent assay, and the fasting blood glucose of each group was monitored. The correlation between the levels of PTX3 and 25(OH)2D3 in serum and the occurrence of T2DM combined with OP was analyzed by statistical method. Results: The serum PTX3 level in group A was significantly higher than that in group B and group C, 25(OH)2D3 was significantly lower than that in group B and group C, and fasting blood glucose was significantly higher than that in group B and group C. The area under the ROC curve of serum PTX3, 25(OH)2D3 and combined detection in predicting T2DM with OP was 0.647 (95%CI: 0.506-0.788), 0.914 (95%CI: 0.844-0.984) and 0.974 (95%CI: 0.941-1.000), respectively. The area under the ROC curve of combined detection of PTX3 and 25(OH)2D3 for the diagnosis of T2DM with OP was significantly larger than that of PTX3 and 25(OH)2D3 alone. Conclusion: The expression level of serum PTX3 in T2DM patients with OP is increased, and the expression of 25(OH)2D3 sdecreased. The combined detection of the two is helpful for the diagnosis of T2DM with OP.
JIN Shiwen
,
LI Rui
,
WANG Hengzhe
,
PEI Xiaodong
. Diagnostic value of serumpentraxin 3 and 25 hydroxyvitamin D3 in type 2 diabetes mellitus complicated with osteoporosis[J]. Journal of Baotou Medical College, 2025
, 41(5)
: 58
-62
.
DOI: 10.16833/j.cnki.jbmc.2025.05.011
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