Objective:To study the correlation between atrial fibrillation (AF) and micro RNA-21 (miRNA-21) through clinical data, in order to provide reference value for clinical diagnosis and treatment of AF. Methods: A total of 142 patients who were hospitalized in the Department of Cardiology of a tertiary hospital in Tianjin from September 2022 to December 2023 were collected. According to the results of 12-lead surface electrocardiogram, 70 patients who met the conditions of ′P wave disappeared, replaced by small f waves of different sizes and shapes, and RR interval was absolutely irregular′ were included in the AF group, and the remaining 72 patients were included in the control group. Plasma miRNA-21 and echocardiography were compared between the two groups. Results: Compared with the control group, the dosage of anticoagulants such as rivaroxaban, dabigatran etexilate, warfarin and amiodarone in AF group was significantly higher than that in control group (P＜0.05), the level of low density lipoprotein cholesterol (LDLc) was lower (P＜0.05), the diameter of left atrium was larger (P＜0.05), and the expression of miRNA-21 in plasma was higher (P＜0.05). Logistic regression analysis showed that the occurrence of AF was related to left atrial diameter and miRNA-21 indexes (P＜0.05). Conclusion: The occurrence of AF may be correlated with the expression of miRNA-21 in plasma and the size of left atrium.
[1] Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics-2020 update: a report from the American heart association[J]. Circulation, 2020, 141(9): e139-e596.
[2] Wang YH, Zhang L, Wang J, et al. Clinical characteristics of patients with atrial fibrillation and moderate to severe atrial functional mitral regurgitation[J]. J Nanjing Med Univ, 2024, 44(11): 1558-1565.
[3] Deferm S, Bertrand PB, Verbrugge FH, et al. Atrial functional mitral regurgitation: JACC review topic of the week[J]. J Am Coll Cardiol, 2019, 73(19): 2465-2476.
[4] Bentwich I, Avniel A, Karov Y, et al. Identification of hundreds of conserved and nonconserved human microRNAs[J]. Nat Genet, 2005, 37(7): 766-770.
[5] Pushparaj PN, Aarthi JJ, Kumar SD, et al. RNAi and RNAa: the Yin and Yang of RNAome[J]. Bioinformation, 2008, 2(6): 235-237.
[6] Shi YJ, Yang CG, Qiao WB, et al. Exploring the anti-myocardial fibrosis mechanism of Sacubitril/Valsartanin heart failure with preserved ejection fraction based on MicroRNA21-5p targeting Smad7[J]. Chin J Hosp Pharm, 2024, 44(8): 882-887.
[7] Li Q, Zhu B, Xia Z, et al. The correlation between FHF expression in atrial tissue and atrial remodeling in patients with atrial fibrillation[J]. J Clin Cardio, 2024, 40(6): 483-487.
[8] Selcuklu SD, Donoghue MTA, Spillane C. miR-21 as a key regulator of oncogenic processes[J]. Biochem Soc Trans, 2009, 37(4): 918-925.
[9] Lagos-Quintana M, Rauhut R, Yalcin A, et al. Identification of tissue-specific microRNAs from mouse[J]. Curr Biol, 2002, 12(9): 735-739.
[10] Ji RR, Cheng YH, Yue JM, et al. microRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation[J]. Circ Res, 2007, 100(11): 1579-1588.
[11] Suárez Y, Fernández-Hernando C, Pober JS, et al. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells[J]. Circ Res, 2007, 100(8): 1164-1173.
[12] Li QQ, Yao YF, Shi SM, et al. Inhibition of miR-21 alleviated cardiac perivascular fibrosis via repressing EndMT in T1DM[J]. J Cell Mol Med, 2020, 24(1): 910-920.
[13] Tuleta I, Frangogiannis NG. Fibrosis of the diabetic heart: clinical significance, molecular mechanisms, and therapeutic opportunities[J]. Adv Drug Deliv Rev, 2021, 176: 113904.
[14] Brioschi M, D′Alessandra Y, Mapelli M, et al. Impact of sacubitril/valsartan on circulating microRNA in patients with heart failure[J]. Biomedicines, 2023, 11(4): 1037.
[15] Chen SL, Puthanveetil P, Feng B, et al. Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes[J]. J Cell Mol Med, 2014, 18(3): 415-421.
[16] Tao H, Yang JJ, Chen ZW, et al. DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2[J]. Toxicology, 2014, 323: 42-50.
[17] Cheng YH, Liu XJ, Zhang S, et al. microRNA-21 protects against the H2O2 -induced injury on cardiac myocytes via its target gene PDCD4[J]. J Mol Cell Cardiol, 2009, 47(1): 5-14.
[18] Kumarswamy R, Volkmann I, Jazbutyte V, et al. Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21[J]. Arterioscler Thromb Vasc Biol, 2012, 32(2): 361-369.
[19] 周启林, 黄波, 周婉明, 等. 沙库巴曲缬沙坦钠治疗瓣膜病心力衰竭的效果及对血清miRNA-21的影响[J]. 中国当代医药, 2022, 29(19): 61-64, 69.
[20] Litwin SE. Left atrial strain:a single parameter for assessing the dark side of the cardiac cycle[J]. JACC Cardiovasc Imaging, 2020, 13(10): 2114-2116.
[21] Hwang IC, Cho GY, Choi HM, et al. H2FPEF score reflects the left atrial strain and predicts prognosis in patients with heart failure with preserved ejection fraction[J]. J Card Fail, 2021, 27(2): 198-207.
[22] Zhang Y, Qi Y, Li JJ, et al. Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts[J]. Cardiovasc Res, 2021, 117(4): 1091-1102.
[23] Mccauley MD, Hong L, Sridhar A, et al. Ion channel and structural remodeling in obesity-mediated atrial fibrillation[J]. Circ Arrhythm Electrophysiol, 2020, 13(8): e008296.
[24] Avula UMR, Dridi H, Chen BX, et al. Attenuating persistent sodium current-induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress[J]. JCI Insight, 2021, 6(23): e147371.
[25] 王晶, 穆洋, 袁梦寒, 等. 左室心肌做功对不同心功能分级患者左房应变的影响[J]. 中华老年多器官疾病杂志, 2024, 23(11): 815-819.
