Objective:To investigate the protective effect of resveratrol (RES) on liver injury induced by alcohol dependence in rats. Methods: According to the random number table method, SD rats were divided into drinking group and blank control group. The rats in the drinking group were given two bottles of free drinking 20% alcohol every other day to establish an alcohol dependence model, and the rats in the blank control group were given two bottles of free drinking water. After successful modeling, the rats in the drinking group were randomly divided into alcohol dependence model group (AD), RES low, medium and high dose administration groups (Low, Middle, High). After treatment, the activities of catalase (CAT), glutathione peroxidase (GSH-PX), malondialdehyde (MDA) and super oxide dismutase (SOD) in liver tissues were detected. Western Blot was used to detect the protein expression of p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), p-P38 MAPK and p-JNK. Results: Compared with the blank control group, the activity of MDA in liver tissue of AD group was increased (P＜0.05), the activities of CAT, GSH-PX and SOD were decreased (P＜0.05), and the protein expression of p-P38 and p-JNK was significantly increased (P＜0.05). Compared with the AD group, the activity of MDA in the middle and high dose RES groups was significantly decreased (P＜0.05), the activities of CAT, GSH-PX and SOD were significantly increased (P＜0.05), and the expression of p-P38 and p-JNK protein was significantly decreased (P＜0.05). Conclusion: RES can improve the liver injury induced by alcohol dependence in rats, and may reduce the oxidative stress injury of liver tissue by inhibiting the phosphorylation of JNK and P38 proteins in JNK/P38 signaling pathway, and play a protective role in the liver of alcohol dependent rats.
YI Haoran
,
HAN Zhixue
,
LIU Qi
,
ZHENG Tianyi
,
XUE Jiting
,
LIU Li
,
YUE Hui
,
YANG Yong
,
LI Qi
,
LIU Hongfeng
. The protective effect of resveratrol on the liver of alcohol-dependent rats based on JNK/P38 MAPK pathway[J]. Journal of Baotou Medical College, 2025
, 41(4)
: 29
-33
.
DOI: 10.16833/j.cnki.jbmc.2025.04.006
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